PIK5_ORYSJ
ID PIK5_ORYSJ Reviewed; 1125 AA.
AC Q2QZF2; C5NTP2;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Disease resistance protein PIK5-NP {ECO:0000305};
GN Name=PIK5-NP {ECO:0000303|PubMed:18940787};
GN Synonyms=PIKM1 {ECO:0000312|EMBL:BAH79844.1, ECO:0000312|EMBL:BAH79845.1,
GN ECO:0000312|EMBL:BAH79846.1};
GN OrderedLocusNames=Os11g0688832 {ECO:0000312|EMBL:BAT15296.1},
GN LOC_Os11g46200 {ECO:0000312|EMBL:ABA95385.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1] {ECO:0000312|EMBL:BAH79844.1, ECO:0000312|EMBL:BAH79845.1, ECO:0000312|EMBL:BAH79846.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 629-1034, AND IDENTIFICATION.
RC STRAIN=cv. Aichi asahi, cv. Nipponbare, and cv. Norin 22;
RX AGRICOLA=IND44321441; DOI=10.1007/s10327-009-0213-x;
RA Ashikawa I., Wu J., Matsumoto T., Ishikawa R.;
RT "Haplotype diversity and molecular evolution of the rice Pikm locus for
RT blast resistance.";
RL J. Gen. Plant Pathol. 76:37-42(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP IDENTIFICATION, AND FUNCTION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18940787; DOI=10.1534/genetics.108.095034;
RA Ashikawa I., Hayashi N., Yamane H., Kanamori H., Wu J., Matsumoto T.,
RA Ono K., Yano M.;
RT "Two adjacent nucleotide-binding site-leucine-rich repeat class genes are
RT required to confer Pikm-specific rice blast resistance.";
RL Genetics 180:2267-2276(2008).
RN [6]
RP IDENTIFICATION, AND FUNCTION.
RC STRAIN=cv. Nipponbare;
RX PubMed=21118257; DOI=10.1111/j.1469-8137.2010.03462.x;
RA Zhai C., Lin F., Dong Z., He X., Yuan B., Zeng X., Wang L., Pan Q.;
RT "The isolation and characterization of Pik, a rice blast resistance gene
RT which emerged after rice domestication.";
RL New Phytol. 189:321-334(2011).
CC -!- FUNCTION: Probable disease resistance protein. Resistance proteins
CC guard the plant against pathogens that contain an appropriate
CC avirulence protein via an indirect interaction with this avirulence
CC protein. That triggers a defense system including the hypersensitive
CC response, which restricts the pathogen growth. At the opposite of
CC cultivar Kusabue, the cultivar Nipponbare doesn't recognize the
CC effector avirulence protein AVR-Pik from M.oryzae.
CC {ECO:0000305|PubMed:18940787, ECO:0000305|PubMed:21118257}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAT15296.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB510262; BAH79844.1; -; mRNA.
DR EMBL; AB510263; BAH79845.1; -; mRNA.
DR EMBL; AB510264; BAH79846.1; -; mRNA.
DR EMBL; DP000010; ABA95385.1; -; Genomic_DNA.
DR EMBL; AP014967; BAT15296.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; Q2QZF2; -.
DR STRING; 4530.OS11T0688832-00; -.
DR PRIDE; Q2QZF2; -.
DR eggNOG; ENOG502S8PY; Eukaryota.
DR HOGENOM; CLU_000837_14_5_1; -.
DR OrthoDB; 225083at2759; -.
DR Proteomes; UP000059680; Chromosome 11.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..1125
FT /note="Disease resistance protein PIK5-NP"
FT /id="PRO_0000444665"
FT DOMAIN 282..564
FT /note="NB-ARC"
FT /evidence="ECO:0000255"
FT REPEAT 651..673
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 676..700
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 701..723
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 725..746
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 747..769
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 771..793
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 794..816
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 818..841
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 873..898
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 939..966
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 989..1013
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REGION 1..273
FT /note="Structured coiled coil (CC) domain"
FT /evidence="ECO:0000250|UniProtKB:F2VYU4"
SQ SEQUENCE 1125 AA; 127586 MW; A76E59546BDBB66A CRC64;
MAVYSVATGA LAPVLSKLSA LLGDEHLDLA ERTRSDAMFI RSQLEAVHSL LLPRISWGMT
GEEVDALCKD ELMAEVRELS YDMDDAIDEF FLEEPMAGGD GGPFDELKTR VEDVSKRFSD
SRRWRPPVEQ HQPSLTAATV DCPPPHARFV HNMMDVSELV EMDKQHEKEL IKLLEQGADT
SIYASRWRIA TPWHDKEQST VVKVPEREWG FPDNRNSPFI WASDSFERLR SGSLCGDTLR
LDGEGANIRK LLSTLRNKVG RAQLVQVEDK RKRVEEATKP CEFHEVKTIC ILGLPGAGKT
TLAKLLYSHH STTEQQFQHR AFVSLSPGAN LTDTLTDILL QVGAYNDDAT PYCGTGTPHQ
QYLIDNISAY LIGKKYLIII DDVWHWEEWE VIRKSIPKND LGSRIIMTTR LNSIAEKCRN
DDMDAFVYET EALDYVDAWL LCDKVARKSV TCMNINPCYD IVDMCYGMPL ALIRVSSALA
EEIQALDSDE RQIWRALRRV EDGILDIPSL KPLAESLCLG YDHLPLYLRT LLLCCSVYHW
LDGGIVQRGR LVTRWIAEGF VSEEKAAEGY FDELVGRGWM KHRGLNEYEI HPMMLAILRY
KSKEYNFVTC LGTGSDTCTS ASLSYSSPTM AIRRLCLQRG YPMKCFSSMD VSHTRSLVIL
GDVIGVPLDM FKRLRVLDLE DNIGIEDSHL KKICEQLESL RLLKYLGLKG TRITKLPQEI
QKLKQLEILY VRSTGIEELP WEIGELKQLR TLDVRNTRIS ELPSQIGELK HLRTLDVSNM
WNISELPSQI GELKHLQTLD VRNTSVRELP SQIGELKHLR TLDVRNTGVR ELPWQAGQIS
GSLHVHTDDS DEGMRLPEGV CEDLIKGIPK AELAKCSEVL SINIVDRLGS PPIGIFKVIG
LHKSIPKLIK DHFNVLSSLD IRRYNKLEED DHEFLANNMP NLQMLVLRFE APQREPIIIN
RTGFQMLERF LVESRVPRIT FQEGAMPKLK HLEFKFYAGP PSKDPIGITH LKSLQKVVFR
CSKWYKSDNP GIKAAIDVVK KEARQHPNRP ISLLITEGDK EVPNIEAHGS SENIVVVHAA
PDDAISCSSC GRTSTSIQEG TVRDRIPAMD LFWPEFNSYE KAKRN
