ID   PIK6_ORYSJ              Reviewed;        1044 AA.
AC   Q2QZF1;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Disease resistance protein PIK6-NP {ECO:0000305};
GN   Name=PIK6-NP {ECO:0000303|PubMed:18940787};
GN   OrderedLocusNames=Os11g0689100 {ECO:0000312|EMBL:BAF28850.1},
GN   LOC_Os11g46210 {ECO:0000312|EMBL:ABA95386.1};
GN   ORFNames=OsJ_26447 {ECO:0000312|EMBL:EAZ41900.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT   genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [7]
RP   IDENTIFICATION, AND FUNCTION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18940787; DOI=10.1534/genetics.108.095034;
RA   Ashikawa I., Hayashi N., Yamane H., Kanamori H., Wu J., Matsumoto T.,
RA   Ono K., Yano M.;
RT   "Two adjacent nucleotide-binding site-leucine-rich repeat class genes are
RT   required to confer Pikm-specific rice blast resistance.";
RL   Genetics 180:2267-2276(2008).
RN   [8]
RP   IDENTIFICATION, AND FUNCTION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=21118257; DOI=10.1111/j.1469-8137.2010.03462.x;
RA   Zhai C., Lin F., Dong Z., He X., Yuan B., Zeng X., Wang L., Pan Q.;
RT   "The isolation and characterization of Pik, a rice blast resistance gene
RT   which emerged after rice domestication.";
RL   New Phytol. 189:321-334(2011).
CC   -!- FUNCTION: Probable disease resistance protein. Resistance proteins
CC       guard the plant against pathogens that contain an appropriate
CC       avirulence protein via an indirect interaction with this avirulence
CC       protein. That triggers a defense system including the hypersensitive
CC       response, which restricts the pathogen growth. At the opposite of
CC       cultivar Kusabue, the cultivar Nipponbare doesn't recognize the
CC       effector avirulence protein AVR-Pik from M.oryzae.
CC       {ECO:0000305|PubMed:18940787, ECO:0000305|PubMed:21118257}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
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DR   EMBL; AP011111; BAM28949.1; -; Genomic_DNA.
DR   EMBL; DP000010; ABA95386.1; -; Genomic_DNA.
DR   EMBL; AP008217; BAF28850.1; -; Genomic_DNA.
DR   EMBL; AP014967; BAT15298.1; -; Genomic_DNA.
DR   EMBL; CM000145; EAZ41900.1; -; Genomic_DNA.
DR   EMBL; AK073759; BAG93625.1; -; mRNA.
DR   RefSeq; XP_015617985.1; XM_015762499.1.
DR   AlphaFoldDB; Q2QZF1; -.
DR   SMR; Q2QZF1; -.
DR   STRING; 4530.OS11T0689100-01; -.
DR   PaxDb; Q2QZF1; -.
DR   PRIDE; Q2QZF1; -.
DR   EnsemblPlants; Os11t0689100-01; Os11t0689100-01; Os11g0689100.
DR   GeneID; 4351153; -.
DR   Gramene; Os11t0689100-01; Os11t0689100-01; Os11g0689100.
DR   KEGG; osa:4351153; -.
DR   eggNOG; KOG4658; Eukaryota.
DR   InParanoid; Q2QZF1; -.
DR   OMA; KPQESDH; -.
DR   OrthoDB; 297378at2759; -.
DR   Proteomes; UP000000763; Chromosome 11.
DR   Proteomes; UP000007752; Chromosome 8.
DR   Proteomes; UP000059680; Chromosome 11.
DR   ExpressionAtlas; Q2QZF1; baseline and differential.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 2.
DR   Pfam; PF18052; Rx_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW   Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..1044
FT                   /note="Disease resistance protein PIK6-NP"
FT                   /id="PRO_0000444666"
FT   DOMAIN          187..543
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000255"
FT   REPEAT          635..657
FT                   /note="LRR 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          682..705
FT                   /note="LRR 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          706..728
FT                   /note="LRR 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          808..834
FT                   /note="LRR 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          840..862
FT                   /note="LRR 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          866..888
FT                   /note="LRR 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          889..911
FT                   /note="LRR 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          935..958
FT                   /note="LRR 8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          980..1004
FT                   /note="LRR 9"
FT                   /evidence="ECO:0000255"
FT   REGION          3..184
FT                   /note="Structured coiled coil (CC) domain"
FT                   /evidence="ECO:0000250|UniProtKB:B5UBC0"
FT   REGION          258..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          737..771
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..293
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1044 AA;  117003 MW;  8B0E269C92C16744 CRC64;
     MELAVGASEA TMRSLLGKLG NLLAQEYSLV SGVRGDIQYI NDELASMQAF LRDLSVVTEG
     HNHDNRRKDW MKQIRDVAYD VEDCIDDFAH RLPQDSISDA KCSFILTKMY ELLTWWPRRD
     IASRIAELKV RAQQIADRRN RYGVNNPEHC DSSNSPRPRA HAAAQDIAEY QDTKPQIVSI
     KEPVGMKTVM ENLEKWLTEP QPDKGRAVLS IVGFGGVGKT TIAMALYRKV SGKFDCQASV
     AVSQNYDEDE VLRSILNQVS KQEEAGGSTE SSSRDENTRE PQGSSSTSSR EENTAESGTK
     RMLNKLKKAL PLSLLGGNDD KTSVRQQETM GSLQLREELK RRLAEKRYIL LIDDIWSAKT
     WNSIIIPFLP SENDKDSRII VTTRFHAVGS TCSPRHKNDE ATSSPGHGKD LLHKVDFLTG
     DKPLDLFNAS IPDPMKRTDR DKKLSKICGG LPLAIVTMAG LVACNPNKAN SDWSKLCESL
     FPYPVTTLNL DGVTRILDCC YNDLPADLKT CLLYLSIFPK GWKISRKRLA RRWIAEGFAT
     EKQGLTEEEV AEAYFNQLAR RNLIRPVEHG SNGKVKAFQV HDMVLEYIMS KSIEENFITV
     VGGHWQMTAP SNKVRRLSLQ SSGSKHGNST KGLNLAQVRS LTVFGNLNHV PFHSFNYGII
     QVLDLEGWKG LKERHVTEIC QMLVLKYLSI RRTEIAKIPS KIEKLEYLET LDIRETYVEE
     LPKSVGQLKR ISSILGGNKN TRKGLRLPQE KRNKAMKNPS PQGKTKEPAE KGFLSQEKAK
     GTMKSLRVLS GIEIVDESAA VAASLHQLTG LRKLAIYKLK ISEENDTFKE LLSSIEYLGS
     CGLQTLAIND ENSKFINSLY NMSAPPRYLV SLELSGKLKW LPEWITSITT LNKLTISITV
     LTTETLEILR NLPSLFSLTF AFSLSAAKQD QDTVKGILED NKLATDGEIV IPAKEFKSLK
     LLRFFAPFVP KLSFPDKSAM PALEIIEMRF QEFEGLFGIE ILENLREVHL KVSDGAEAIT
     KFLVSDLKDN TEKPKVFVDG IVTA