PIKS1_ORYSJ
ID PIKS1_ORYSJ Reviewed; 1143 AA.
AC P0DO09; D5L9G0;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 18-JUL-2018, sequence version 1.
DT 03-AUG-2022, entry version 10.
DE RecName: Full=Disease resistance protein Piks-1 {ECO:0000305};
DE AltName: Full=NBS-LRR class disease resistance protein Piks-1 {ECO:0000312|EMBL:AET36547.1};
GN Name=PIKS-1 {ECO:0000312|EMBL:AET36547.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1] {ECO:0000312|EMBL:AET36547.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Pan Q., Zhai C., Dong Z., Lin F., Wang L.;
RT "The rice blast resistance gene Piks forms a allelic series with Pik-m, Pik
RT and Pik-p.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Disease resistance (R) protein that specifically recognizes
CC the AVR-Pik effector avirulence protein from M.oryzae. Resistance
CC proteins guard the plant against pathogens that contain an appropriate
CC avirulence protein via an indirect interaction with this avirulence
CC protein. That triggers a defense system including the hypersensitive
CC response, which restricts the pathogen growth.
CC {ECO:0000250|UniProtKB:F2VYU4}.
CC -!- SUBUNIT: Interacts with AVR-Pik through its N-terminal part containing
CC the HMA-like domain. {ECO:0000250|UniProtKB:F2VYU4}.
CC -!- DOMAIN: The HMA-like (RATX1) domain is responsible for the specific
CC recognition of AVR effectors. {ECO:0000250|UniProtKB:F2VYU4}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
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DR EMBL; HQ662329; AET36547.1; -; Genomic_DNA.
DR AlphaFoldDB; P0DO09; -.
DR SMR; P0DO09; -.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 2.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Repeat.
FT CHAIN 1..1143
FT /note="Disease resistance protein Piks-1"
FT /id="PRO_0000444669"
FT DOMAIN 189..258
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT DOMAIN 282..570
FT /note="NB-ARC"
FT /evidence="ECO:0000255"
FT REPEAT 681..706
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 708..731
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 732..754
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 756..777
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 778..800
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 802..823
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 824..848
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 945..968
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 979..1002
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 1004..1027
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REGION 1..190
FT /note="Structured coiled coil (CC) domain"
FT /evidence="ECO:0000250|UniProtKB:F2VYU4"
FT REGION 191..264
FT /note="HMA-like domain"
FT /evidence="ECO:0000250|UniProtKB:F2VYU4"
SQ SEQUENCE 1143 AA; 126828 MW; 72D02B7037902E82 CRC64;
MEAAAMAVTA ATGALAPVLV KLAALLDDGE CNLLEGSRSD AEFIRSELEA VHSLLTPNIL
GRMGDDDAAC KDGLIAEVRE LSYDLDDAVD DFLELNFEQR RSASPFGELK ARVEERVSNR
FSDWKLPAAS LPPSSVHRRA GLPPPDAGLV GMHKRKEELI ELLEQGSSDA SRWRKRKPHV
PLRIMGGEMQ KIVFKIPMVD DKSRTKAMSL VASTVGVHSV AIAGDLRDEV VVVGDGIDSI
NLVSALRKKV GPAMFLEVSQ AKEDVKEITA MLAPVKSICE FHEVKTICIL GLPGGGKTTI
ARVLYHALGT QFQCRVFASI SPSSSPSPNL TETLADIFAQ AQLGVTDTLS TPYGGSGTGR
ALQQHLIDNI SAFLLNKKYL IVIDDIWHWE EWEVIRKSIP KNDLGGRIIM TTRLNSIAEK
CHTDDNDVFV YEVGDLDNND AWSLSWGIAT KSGAGNRIGT GEDNSCYDIV NMCYGMPLAL
IWLSSALVGE IEELGGAEVK KCRDLRHIED GILDIPSLQP LAESLCLGYN HLPLYLRTLL
LYCSAYHWSN RIERGRLVRR WIAEGFVSEE KEAEGYFGEL INRGWITQHG DNNSYNYYEI
HPVMLAFLRC KSKEYNFLTC LGLGSDTSTS ASSPRLIRRL SLQGGYPVDC LSSMSMDVSH
TCSLVVLGDV ARPKGIPFYM FKRLRVLDLE DNKDIQDSHL QGICEQLSLR VRYLGLKGTR
IRKLPQEMRK LKHLEILYVG STRISELPQE IGELKHLRIL DVRNTDITEL PLQIRELQHL
HTLDVRNTPI SELPPQVGKL QNLKIMCVRS TGVRELPKEI GELNHLQTLD VRNTRVRELP
WQAGQISQSL RVLAGDSGDG VRLPEGVCEA LINGIPGATR AKCREVLSIA IIDRFGPPLV
GIFKVPGSHM RIPKMIKDHF RVLSCLDIRL CHKLEDDDQK FLAEMPNLQT LVLRFEALPR
QPITINGTGF QMLESFRVDS RVPRIAFHED AMPNLKLLEF KFYAGPASND AIGITNLKSL
QKVVFRCSPW YKSDAPGISA TIDVVKKEAE EHPNRPITLL INAGYKEIST ESHGSSENIA
GSSGIDTEPA QAQHDNLPAV RDDYKGKGIL LDGRCPTCGR ATKIEEETQD RVADIEIQTE
TTS
