ID   PILC_VIBCH              Reviewed;         408 AA.
AC   Q9X4G9;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Type IV pilin assembly protein PilC;
DE   AltName: Full=Type IV-A pilus assembly protein PilC;
GN   Name=pilC; OrderedLocusNames=VC_2425;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10024587; DOI=10.1128/iai.67.3.1393-1404.1999;
RA   Fullner K.J., Mekalanos J.J.;
RT   "Genetic characterization of a new type IV-A pilus gene cluster found in
RT   both classical and El Tor biotypes of Vibrio cholerae.";
RL   Infect. Immun. 67:1393-1404(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Involved in the translocation of the type IV pilin.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GSP F family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF109904; AAD21031.1; -; Genomic_DNA.
DR   EMBL; AE003852; AAF95568.1; -; Genomic_DNA.
DR   PIR; A82078; A82078.
DR   RefSeq; NP_232055.1; NC_002505.1.
DR   RefSeq; WP_000648511.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9X4G9; -.
DR   SMR; Q9X4G9; -.
DR   STRING; 243277.VC_2425; -.
DR   DNASU; 2612967; -.
DR   EnsemblBacteria; AAF95568; AAF95568; VC_2425.
DR   GeneID; 57741031; -.
DR   KEGG; vch:VC_2425; -.
DR   PATRIC; fig|243277.26.peg.2308; -.
DR   eggNOG; COG1459; Bacteria.
DR   HOGENOM; CLU_035032_2_1_6; -.
DR   OMA; TRQMATM; -.
DR   BioCyc; VCHO:VC2425-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015628; P:protein secretion by the type II secretion system; IBA:GO_Central.
DR   Gene3D; 1.20.81.30; -; 2.
DR   InterPro; IPR003004; GspF/PilC.
DR   InterPro; IPR001992; T2SS_GspF/T4SS_PilC_CS.
DR   InterPro; IPR018076; T2SS_GspF_dom.
DR   InterPro; IPR042094; T2SS_GspF_sf.
DR   PANTHER; PTHR30012; PTHR30012; 1.
DR   Pfam; PF00482; T2SSF; 2.
DR   PRINTS; PR00812; BCTERIALGSPF.
DR   PROSITE; PS00874; T2SP_F; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Fimbrium biogenesis; Membrane;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..408
FT                   /note="Type IV pilin assembly protein PilC"
FT                   /id="PRO_0000207842"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   408 AA;  45134 MW;  07D4C9768685A615 CRC64;
     MKATQTLPLK NYRWKGINSN GKKVSGQMLA ISEIEVRDKL KDQHIQIKKL KKGSVSLLAR
     LTHRVKSKDI TILTRQLATM LTTGVPIVQA LKLVGDNHRK AEMKSILAQI TKSVEAGTPL
     SKAMRTASAH FDTLYVDLVE TGEMSGNLPE VFERLATYRE KSEQLRAKVI KALIYPSMVV
     LVALGVSYLM LTMVIPEFES MFKGFGAELP WFTQQVLKLS HWVQAYSLWA FIAIAAAIFG
     LKALRKNSFQ IRLKTSRLGL KFPIIGNVLA KASIAKFSRT LATSFAAGIP ILASLKTTAK
     TSGNVHFETA INEVYRDTAA GMPMYIAMRN TEAFPEMVLQ MVMIGEESGQ LDDMLNKVAT
     IYEFEVDNTV DNLGKILEPL IIVFLGTVVG GLVVAMYLPI FNLMSVLG