ID   PILIN_MYCBP             Reviewed;         103 AA.
AC   A1KNZ9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Pilin;
DE   AltName: Full=Pili structural subunit;
DE   Flags: Precursor;
GN   Name=mtp; OrderedLocusNames=BCG_3378c;
OS   Mycobacterium bovis (strain BCG / Pasteur 1173P2).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=410289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCG / Pasteur 1173P2;
RX   PubMed=17372194; DOI=10.1073/pnas.0700869104;
RA   Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P.,
RA   Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K.,
RA   Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C.,
RA   Barrell B.G., Parkhill J., Cole S.T.;
RT   "Genome plasticity of BCG and impact on vaccine efficacy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007).
CC   -!- FUNCTION: Structural subunit of pili, which are thin, flexible, coiled-
CC       coil, aggregative fibers. Mediates adhesion to the extracellular
CC       matrix, an event that would facilitate direct interaction with the host
CC       epithelium during infection in the lung or other tissues (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a homomer composed of subunits assembled in a large
CC       structure. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}. Note=Part of the pili
CC       surface structure. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mycobacterial pilin family. {ECO:0000305}.
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DR   EMBL; AM408590; CAL73367.1; -; Genomic_DNA.
DR   RefSeq; WP_003417257.1; NC_008769.1.
DR   AlphaFoldDB; A1KNZ9; -.
DR   GeneID; 45427312; -.
DR   KEGG; mbb:BCG_3378c; -.
DR   HOGENOM; CLU_2260590_0_0_11; -.
DR   OMA; WEFGECH; -.
DR   Proteomes; UP000001472; Chromosome.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell adhesion; Fimbrium; Signal; Virulence.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..103
FT                   /note="Pilin"
FT                   /id="PRO_0000314594"
FT   REGION          61..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   103 AA;  10768 MW;  2E02E76F1E4885D1 CRC64;
     MYRFACRTLM LAACILATGV AGLGVGAQSA AQTAPVPDYY WCPGQPFDPA WGPNWDPYTC
     HDDFHRDSDG PDHSRDYPGP ILEGPVLDDP GAAPPPPAAG GGA