ID   PILQ_NEIG1              Reviewed;         723 AA.
AC   Q5FAD2;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Type IV pilus biogenesis and competence protein PilQ;
DE   AltName: Full=Outer membrane protein Omc;
DE   Flags: Precursor;
GN   Name=pilQ; Synonyms=omc; OrderedLocusNames=NGO0094;
OS   Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=242231;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700825 / FA 1090;
RA   Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F.,
RA   Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C.,
RA   Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H., Qi S.,
RA   Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.;
RT   "The complete genome sequence of Neisseria gonorrhoeae.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=14729699; DOI=10.1128/jb.186.3.730-739.2004;
RA   Chen C.-J., Tobiason D.M., Thomas C.E., Shafer W.M., Seifert H.S.,
RA   Sparling P.F.;
RT   "A mutant form of the Neisseria gonorrhoeae pilus secretin protein PilQ
RT   allows increased entry of heme and antimicrobial compounds.";
RL   J. Bacteriol. 186:730-739(2004).
CC   -!- FUNCTION: Required for type IV pilus biogenesis and competence. Could
CC       function as a pore for exit of the pilus but also as a channel for
CC       entry of heme and antimicrobial agents and uptake of transforming DNA.
CC       {ECO:0000269|PubMed:14729699}.
CC   -!- SUBUNIT: Homododecamer. Tetramer of trimer (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane. Note=Associated to the
CC       membrane through its C-terminus.
CC   -!- DISRUPTION PHENOTYPE: Cells show decreased piliation and transformation
CC       efficiency. It uses hemoglobin as a heme and iron source in the absence
CC       of a hemoglobin receptor and it has elevated sensitivities to various
CC       antimicrobial compounds. {ECO:0000269|PubMed:14729699}.
CC   -!- SIMILARITY: Belongs to the bacterial secretin family. PilQ subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE004969; AAW88855.1; -; Genomic_DNA.
DR   RefSeq; WP_003698035.1; NC_002946.2.
DR   RefSeq; YP_207267.1; NC_002946.2.
DR   AlphaFoldDB; Q5FAD2; -.
DR   BMRB; Q5FAD2; -.
DR   SMR; Q5FAD2; -.
DR   STRING; 242231.NGO_0094; -.
DR   PRIDE; Q5FAD2; -.
DR   EnsemblBacteria; AAW88855; AAW88855; NGO_0094.
DR   KEGG; ngo:NGO_0094; -.
DR   PATRIC; fig|242231.10.peg.126; -.
DR   HOGENOM; CLU_006756_0_1_4; -.
DR   OMA; TRTNTIW; -.
DR   Proteomes; UP000000535; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.30.1370.120; -; 1.
DR   InterPro; IPR021731; AMIN_dom.
DR   InterPro; IPR001775; GspD/PilQ.
DR   InterPro; IPR005644; NolW-like.
DR   InterPro; IPR038591; NolW-like_sf.
DR   InterPro; IPR013355; Pilus_4_PilQ.
DR   InterPro; IPR011662; Secretin/TonB_short_N.
DR   InterPro; IPR004846; T2SS/T3SS.
DR   InterPro; IPR004845; T2SS_GspD_CS.
DR   Pfam; PF11741; AMIN; 1.
DR   Pfam; PF00263; Secretin; 1.
DR   Pfam; PF03958; Secretin_N; 1.
DR   Pfam; PF07660; STN; 1.
DR   PRINTS; PR00811; BCTERIALGSPD.
DR   SMART; SM00965; STN; 1.
DR   TIGRFAMs; TIGR02515; IV_pilus_PilQ; 1.
DR   PROSITE; PS00875; T2SP_D; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Competence; Membrane; Protein transport;
KW   Reference proteome; Signal; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..723
FT                   /note="Type IV pilus biogenesis and competence protein
FT                   PilQ"
FT                   /id="PRO_0000013114"
SQ   SEQUENCE   723 AA;  77951 MW;  EDE9A3D62101EBBE CRC64;
     MNTKLTKIIS GLFVATAAFQ TASAGNITDI KVSSLPNKQK IVKVSFDKEI VNPTGFVTSS
     PARIALDFEQ TGISMDQQVL EYADPLLSKI SAAQNSSRAR LVLNLNKPGQ YNTEVRGNKV
     WIFINESDDT VSAPARPAVK AAPAAPAKQQ AAAPFTESVV SVSAPFSPAK QQAAASAKQT
     NIDFRKDGKN AGIIELAALG FAGQPDISQQ HDHIIVTLKN HTLPTALQRS LDVADFKTPV
     QKVTLKRLNN DTQLIITTTG NWELVNKSAA PGYFTFQVLP KKQNLESGGV NNAPKTFTGR
     KISLDFQDVE IRTILQILAK ESGMNIVASD SVSGKMTLSL KDVPWDQALD LVMQARNLDM
     RQQGNIVNIA PRDELLAKDK AFLQAEKDIA DLGALYSQNF QLKYKNVEEF RSILRLDNAD
     TTGNRNTLVS GRGSVLIDPA TNTLIVTDTR SVIEKFRKLI DELDVPAQQV MIEARIVEAA
     DGFSRDLGVK FGATGRKKLK NETSAFGWGV NSGFGGGDKW EAQTKINLPV AAAANSISLV
     RAISSGALNL ELSASESLSK TKTLANPRVL TQNRKEAKIE SGYEIPFTVT TASGGGNSTN
     TELKKAVLGL TVTPNITPDG QIIMTVKINK DSPAQCASGN NTILCISTKS LNTQAMVENG
     GTLIVGGIYE ENNGNTLTKV PLLGDIPVIG NLFKTRGKKT DRRELLIFIT PRIIDTAGNS
     LRY