ID   PILQ_NEIGO              Reviewed;         720 AA.
AC   P35819; Q50972;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Type IV pilus biogenesis and competence protein PilQ;
DE   AltName: Full=Outer membrane protein Omc;
DE   Flags: Precursor;
GN   Name=pilQ; Synonyms=omc;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=2686;
RX   PubMed=2503445; DOI=10.1128/iai.57.9.2653-2659.1989;
RA   Tsai W.M., Larsen S.H., Wilde C.E.;
RT   "Cloning and DNA sequence of the omc gene encoding the outer membrane
RT   protein-macromolecular complex from Neisseria gonorrhoeae.";
RL   Infect. Immun. 57:2653-2659(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=MS11;
RX   PubMed=8825101; DOI=10.1111/j.1365-2958.1995.18050975.x;
RA   Drake S.L., Koomey M.;
RT   "The product of the pilQ gene is essential for the biogenesis of type IV
RT   pili in Neisseria gonorrhoeae.";
RL   Mol. Microbiol. 18:975-986(1995).
CC   -!- FUNCTION: Required for type IV pilus biogenesis and competence. Could
CC       function as a pore for exit of the pilus but also as a channel for
CC       entry of heme and antimicrobial agents and uptake of transforming DNA.
CC       {ECO:0000269|PubMed:8825101}.
CC   -!- SUBUNIT: Homododecamer. Tetramer of trimer (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane. Note=Associated with the
CC       membrane through its C-terminus.
CC   -!- SIMILARITY: Belongs to the bacterial secretin family. PilQ subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA25456.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L19944; AAA25456.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; U40596; AAC43603.1; -; Genomic_DNA.
DR   PIR; A37051; A37051.
DR   PIR; S70838; S70838.
DR   AlphaFoldDB; P35819; -.
DR   BMRB; P35819; -.
DR   SMR; P35819; -.
DR   PRIDE; P35819; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.30.1370.120; -; 1.
DR   InterPro; IPR021731; AMIN_dom.
DR   InterPro; IPR001775; GspD/PilQ.
DR   InterPro; IPR005644; NolW-like.
DR   InterPro; IPR038591; NolW-like_sf.
DR   InterPro; IPR013355; Pilus_4_PilQ.
DR   InterPro; IPR011662; Secretin/TonB_short_N.
DR   InterPro; IPR004846; T2SS/T3SS.
DR   InterPro; IPR004845; T2SS_GspD_CS.
DR   Pfam; PF11741; AMIN; 1.
DR   Pfam; PF00263; Secretin; 1.
DR   Pfam; PF03958; Secretin_N; 1.
DR   PRINTS; PR00811; BCTERIALGSPD.
DR   SMART; SM00965; STN; 1.
DR   TIGRFAMs; TIGR02515; IV_pilus_PilQ; 1.
DR   PROSITE; PS00875; T2SP_D; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Competence; Membrane; Protein transport; Signal;
KW   Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..720
FT                   /note="Type IV pilus biogenesis and competence protein
FT                   PilQ"
FT                   /id="PRO_0000013115"
FT   REGION          697..720
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   720 AA;  77597 MW;  A45BE2AD06DEE92B CRC64;
     MNTKLTKIIS GLFVATAAFQ TASAGNITDI KVSSLPNKQK IVKVSFDKEI VNPTGFVTSS
     PARIALDFEQ TGISMDQQVL EYADPLLSKI SAAQNSSRAR LVLNLNKPGQ YNTEVRGNKV
     WIFINESDDT VSAPARPAVK AAPAAPAKQQ AAAPFTESVV SVSAPFSPAK QQAAASAKQQ
     AATPAKQTNI DFRKDGKNAG IIELAALGFA GQPDISQQHD HIIVTLKNHT LPTALQRSLD
     VADFKTPVQK VTLKRLNNDT QLIITTTGNW ELVNKSAAPG YFTFQVLPKK QNLESGGVNN
     APKTFTGRKI SLDFQDVEIR TILQILAKES GMNIVASDSV SGKMTLSLKD VPWDQALDLV
     MQARNLDMRQ QGNIVNMAPR RAACQRQSLL TSGKRHCRSG RAVFPKLPIE IQKCGRIPQH
     PALDNADTTG NRNTLVSGRG SVLIDPATNT LIVTDTRSVI EKFRKLIDEL DVPAQQVMIE
     ARIVEAADGF SRDLGVKFGA TGRKKLKNET SAFGWGVNSG FGGGDKWEAK PKSTCRLPCR
     KQHFAGARDF SGALNLELSA SESLSKTKTL ANPRVLTQNR KEAKIESGYE IPFTVTTRSG
     GGNSTNTELK KAVLGLTVTA NITPDGQIIM TVKINKDSPR QCASGNNTIL CISTKSLNTQ
     AMVENGGTLI VGGIYEENNG NTLTKVPLLA TSPLSATSLK HSGKNRPPRT ADFQLPPREL