PILQ_NEIMH
ID PILQ_NEIMH Reviewed; 777 AA.
AC Q9ZHF3; E6MYG3;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Type IV pilus biogenesis and competence protein PilQ;
DE Flags: Precursor;
GN Name=pilQ; OrderedLocusNames=NMBH4476_1758; ORFNames=NMH_1547;
OS Neisseria meningitidis serogroup B / serotype 15 (strain H44/76).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=909420;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=H44/76;
RX PubMed=9701807; DOI=10.1046/j.1365-2958.1998.00910.x;
RA Toenjum T., Caugant D.A., Dunham S.A., Koomey M.;
RT "Structure and function of repetitive sequence elements associated with a
RT highly polymorphic domain of the Neisseria meningitidis PilQ protein.";
RL Mol. Microbiol. 29:111-124(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H44/76;
RX PubMed=21378179; DOI=10.1128/jb.01331-10;
RA Piet J.R., Huis In 't Veld R.A., van Schaik B.D., van Kampen A.H., Baas F.,
RA van de Beek D., Pannekoek Y., van der Ende A.;
RT "Genome sequence of Neisseria meningitidis serogroup B strain H44/76.";
RL J. Bacteriol. 193:2371-2372(2011).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H44/76;
RX PubMed=21368196; DOI=10.1073/pnas.1019751108;
RA Budroni S., Siena E., Hotopp J.C., Seib K.L., Serruto D., Nofroni C.,
RA Comanducci M., Riley D.R., Daugherty S.C., Angiuoli S.V., Covacci A.,
RA Pizza M., Rappuoli R., Moxon E.R., Tettelin H., Medini D.;
RT "Neisseria meningitidis is structured in clades associated with restriction
RT modification systems that modulate homologous recombination.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4494-4499(2011).
CC -!- FUNCTION: Required for type IV pilus biogenesis and competence. Could
CC function as a pore for exit of the pilus but also as a channel for
CC entry of heme and antimicrobial agents and uptake of transforming DNA
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homododecamer. Tetramer of trimer (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. PilQ subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF066056; AAC96097.1; -; Genomic_DNA.
DR EMBL; AEQZ01000037; EFV63384.1; -; Genomic_DNA.
DR EMBL; CP002420; ADY96329.1; -; Genomic_DNA.
DR RefSeq; WP_009348000.1; NZ_AEQZ01000037.1.
DR AlphaFoldDB; Q9ZHF3; -.
DR BMRB; Q9ZHF3; -.
DR SMR; Q9ZHF3; -.
DR TCDB; 1.B.22.2.2; the outer bacterial membrane secretin (secretin) family.
DR EnsemblBacteria; EFV63384; EFV63384; NMH_1547.
DR KEGG; nmh:NMBH4476_1758; -.
DR PATRIC; fig|909420.3.peg.2335; -.
DR HOGENOM; CLU_006756_0_1_4; -.
DR OMA; QNVPWDQ; -.
DR BioCyc; NMEN909420:NMBH4476_RS09750-MON; -.
DR Proteomes; UP000032707; Unassembled WGS sequence.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.30.1370.120; -; 1.
DR InterPro; IPR021731; AMIN_dom.
DR InterPro; IPR001775; GspD/PilQ.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR013355; Pilus_4_PilQ.
DR InterPro; IPR011662; Secretin/TonB_short_N.
DR InterPro; IPR004846; T2SS/T3SS.
DR InterPro; IPR004845; T2SS_GspD_CS.
DR Pfam; PF11741; AMIN; 1.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 1.
DR Pfam; PF07660; STN; 1.
DR PRINTS; PR00811; BCTERIALGSPD.
DR SMART; SM00965; STN; 1.
DR TIGRFAMs; TIGR02515; IV_pilus_PilQ; 1.
DR PROSITE; PS00875; T2SP_D; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Competence; Membrane; Protein transport; Signal;
KW Transport.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..777
FT /note="Type IV pilus biogenesis and competence protein
FT PilQ"
FT /id="PRO_0000013118"
FT REGION 135..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 214
FT /note="P -> S (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="T -> A (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 387
FT /note="N -> S (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 423
FT /note="I -> M (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 427..469
FT /note="DELLAKDKALLQAEKDIADLGALYSQNFQLKYKNVEEFRSILR -> RAACQ
FT RQSLLTTGKRHCRSGRAVFPKLPIEIQKCGRIPQHPA (in Ref. 1;
FT AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 483
FT /note="I -> V (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 550
FT /note="K -> R (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 556
FT /note="D -> E (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 571
FT /note="D -> G (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 575..598
FT /note="GAETKINLPITAAANSISLVRAIS -> EAKPKSTCRLPCRKQHFAGARDF
FT (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 615
FT /note="T -> P (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 646..648
FT /note="IAN -> RSG (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 688
FT /note="A -> R (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
FT CONFLICT 738..777
FT /note="GDIPVIGNLFKTRGKKTDRRELLIFITPRIMGTAGNSLRY -> ATSPLSAT
FT SLKHGEKNRPPRTADFQLPPREL (in Ref. 1; AAC96097)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 777 AA; 83239 MW; BB14F906477DBA6F CRC64;
MNTKLTKIIS GLFVATAAFQ TASAGNITDI KVSSLPNKQK IVKVSFDKEI VNPTGFVTSS
PARIALDFEQ TGISMDQQVL EYADPLLSKI SAAQNSSRAR LVLNLNKPGQ YNTEVRGNKV
WIFINESDDT VSAPARPAVK AAPAAPAKQQ AAAPSTKSAV SVSEPFTPAK QQAAAPFTES
VVSVSAPFSP AKQQAAASAK QQAAAPAKQQ AAAPAKQQAA APAKQQAAAP AKQTNIDFRK
DGKNAGIIEL AALGFAGQPD ISQQHDHIIV TLKNHTLPTT LQRSLDVADF KTPVQKVTLK
RLNNDTQLII TTAGNWELVN KSAAPGYFTF QVLPKKQNLE SGGVNNAPKT FTGRKISLDF
QDVEIRTILQ ILAKESGMNI VASDSVNGKM TLSLKDVPWD QALDLVMQAR NLDMRQQGNI
VNIAPRDELL AKDKALLQAE KDIADLGALY SQNFQLKYKN VEEFRSILRL DNADTTGNRN
TLISGRGSVL IDPATNTLIV TDTRSVIEKF RKLIDELDVP AQQVMIEARI VEAADGFSRD
LGVKFGATGK KKLKNDTSAF GWGVNSGFGG DDKWGAETKI NLPITAAANS ISLVRAISSG
ALNLELSASE SLSKTKTLAN PRVLTQNRKE AKIESGYEIP FTVTSIANGG SSTNTELKKA
VLGLTVTPNI TPDGQIIMTV KINKDSPAQC ASGNQTILCI STKNLNTQAM VENGGTLIVG
GIYEEDNGNT LTKVPLLGDI PVIGNLFKTR GKKTDRRELL IFITPRIMGT AGNSLRY
