ID   PILQ_PSEAE              Reviewed;         714 AA.
AC   P34750;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   08-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Fimbrial assembly protein PilQ;
DE   Flags: Precursor;
GN   Name=pilQ; OrderedLocusNames=PA5040;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 25102 / PAK;
RX   PubMed=7901733; DOI=10.1111/j.1365-2958.1993.tb01744.x;
RA   Martin P.R., Hobbs M., Free P.D., Jeske Y., Mattick J.S.;
RT   "Characterization of pilQ, a new gene required for the biogenesis of type 4
RT   fimbriae in Pseudomonas aeruginosa.";
RL   Mol. Microbiol. 9:857-868(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Essential for the formation of pili. Involved in the
CC       biogenesis of type 4 fimbriae probably by serving as a 'porthole'
CC       allowing passage of the fimbrae through the outer membrane.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial secretin family. PilQ subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA16704.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; L13865; AAA16704.1; ALT_INIT; Unassigned_DNA.
DR   EMBL; AE004091; AAG08425.1; -; Genomic_DNA.
DR   PIR; A83016; A83016.
DR   PIR; S37345; S37345.
DR   RefSeq; NP_253727.1; NC_002516.2.
DR   RefSeq; WP_003114575.1; NZ_QZGE01000002.1.
DR   PDB; 6VE2; EM; 4.30 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-714.
DR   PDB; 6VE3; EM; 4.30 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-714.
DR   PDB; 6VE4; EM; 6.90 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O=1-714.
DR   PDBsum; 6VE2; -.
DR   PDBsum; 6VE3; -.
DR   PDBsum; 6VE4; -.
DR   AlphaFoldDB; P34750; -.
DR   SMR; P34750; -.
DR   STRING; 287.DR97_2395; -.
DR   TCDB; 1.B.22.2.1; the outer bacterial membrane secretin (secretin) family.
DR   PaxDb; P34750; -.
DR   PRIDE; P34750; -.
DR   EnsemblBacteria; AAG08425; AAG08425; PA5040.
DR   GeneID; 880962; -.
DR   KEGG; pae:PA5040; -.
DR   PATRIC; fig|208964.12.peg.5284; -.
DR   PseudoCAP; PA5040; -.
DR   HOGENOM; CLU_006756_0_2_6; -.
DR   InParanoid; P34750; -.
DR   OMA; QNVPWDQ; -.
DR   PhylomeDB; P34750; -.
DR   BioCyc; PAER208964:G1FZ6-5156-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   GO; GO:0043683; P:type IV pilus assembly; IMP:PseudoCAP.
DR   Gene3D; 3.30.1370.120; -; 1.
DR   InterPro; IPR021731; AMIN_dom.
DR   InterPro; IPR001775; GspD/PilQ.
DR   InterPro; IPR005644; NolW-like.
DR   InterPro; IPR038591; NolW-like_sf.
DR   InterPro; IPR013355; Pilus_4_PilQ.
DR   InterPro; IPR011662; Secretin/TonB_short_N.
DR   InterPro; IPR004846; T2SS/T3SS.
DR   InterPro; IPR004845; T2SS_GspD_CS.
DR   Pfam; PF11741; AMIN; 1.
DR   Pfam; PF00263; Secretin; 1.
DR   Pfam; PF03958; Secretin_N; 1.
DR   Pfam; PF07660; STN; 1.
DR   PRINTS; PR00811; BCTERIALGSPD.
DR   SMART; SM00965; STN; 1.
DR   TIGRFAMs; TIGR02515; IV_pilus_PilQ; 1.
DR   PROSITE; PS00875; T2SP_D; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell outer membrane; Fimbrium biogenesis; Membrane;
KW   Protein transport; Reference proteome; Signal; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..714
FT                   /note="Fimbrial assembly protein PilQ"
FT                   /id="PRO_0000013119"
FT   CONFLICT        391
FT                   /note="D -> E (in Ref. 1; AAA16704)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        411
FT                   /note="G -> A (in Ref. 1; AAA16704)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        547..558
FT                   /note="LSAMEKTGNGEI -> PVGDGKDRQRRV (in Ref. 1; AAA16704)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   714 AA;  77379 MW;  9A748EE8286FBAB5 CRC64;
     MNSGLSRLGI ALLAAMFAPA LLAADLEKLD VAALPGDRVE LKLQFDEPVA APRGYTIEQP
     ARIALDLPGV QNKLGTKNRE LSVGNTRSVT VVEAKDRTRL IINLTALSSY TTRVEGNNLF
     VVVGNSPAGA SVASAAPVKA SPAPASYAQP IKPKPYVPAG RAIRNIDFQR GEKGEGNVVI
     DLSDPTLSPD IQEQGGKIRL DFAKTQLPDA LRVRLDVKDF ATPVQFVNAS AQSDRTSITI
     EPSGLYDYLV YQTDNRLTVS IKPMTTEDAE RRKKDNFAYT GEKLSLNFQD IDVRSVLQLI
     ADFTDLNLVA SDTVQGNITL RLQNVPWDQA LDLVLKTKGL DKRKLGNVLL VAPADEIAAR
     ERQELEAQKQ IAELAPLRRE LIQVNYAKAA DIAKLFQSVT SDGGQEGKEG GRGSITVDDR
     TNSIIAYQPQ ERLDELRRIV SQLDIPVRQV MIEARIVEAN VGYDKSLGVR WGGAYHKGNW
     SGYGKDGNIG IKDEDGMNCG PIAGSCTFPT TGTSKSPSPF VDLGAKDATS GIGIGFITDN
     IILDLQLSAM EKTGNGEIVS QPKVVTSDKE TAKILKGSEV PYQEASSSGA TSTSFKEAAL
     SLEVTPQITP DNRIIVEVKV TKDAPDYQNM LNGVPPINKN EVNAKILVND GETIVIGGVF
     SNEQSKSVEK VPFLGELPYL GRLFRRDTVT DRKNELLVFL TPRIMNNQAI AIGR