PILRB_HUMAN
ID PILRB_HUMAN Reviewed; 227 AA.
AC Q9UKJ0; Q69YF9; Q9HBS0;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Paired immunoglobulin-like type 2 receptor beta;
DE AltName: Full=Activating receptor PILR-beta;
DE AltName: Full=Cell surface receptor FDFACT;
DE Flags: Precursor;
GN Name=PILRB; Synonyms=FDFACT; ORFNames=PP1551;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10660620; DOI=10.1074/jbc.275.6.4467;
RA Mousseau D.D., Banville D., L'Abbe D., Bouchard P., Shen S.H.;
RT "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing
RT protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with
RT the truncated counterpart PILRbeta.";
RL J. Biol. Chem. 275:4467-4474(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Bates E.E.;
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Peripheral blood leukocyte;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Paired receptors consist of highly related activating and
CC inhibitory receptors and are widely involved in the regulation of the
CC immune system. PILRB is thought to act as a cellular signaling
CC activating receptor that associates with ITAM-bearing adapter molecules
CC on the cell surface.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9UKJ0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UKJ0-2; Sequence=VSP_017504;
CC Name=3;
CC IsoId=Q9UKJ0-3; Sequence=VSP_017503, VSP_017504;
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DR EMBL; AF161081; AAD52965.1; -; mRNA.
DR EMBL; AJ400845; CAC19193.1; -; mRNA.
DR EMBL; AJ400846; CAC19194.1; -; mRNA.
DR EMBL; AF217981; AAG17224.1; -; mRNA.
DR EMBL; AL834317; CAH10714.1; -; mRNA.
DR EMBL; AL834336; CAH10711.1; -; mRNA.
DR EMBL; BC050547; AAH50547.1; -; mRNA.
DR CCDS; CCDS43622.1; -. [Q9UKJ0-1]
DR RefSeq; NP_839956.1; NM_178238.3. [Q9UKJ0-1]
DR PDB; 4NFC; X-ray; 2.20 A; A/B=32-150.
DR PDB; 4NFD; X-ray; 1.71 A; A=32-150.
DR PDBsum; 4NFC; -.
DR PDBsum; 4NFD; -.
DR AlphaFoldDB; Q9UKJ0; -.
DR SMR; Q9UKJ0; -.
DR BioGRID; 119015; 45.
DR IntAct; Q9UKJ0; 4.
DR STRING; 9606.ENSP00000391748; -.
DR UniLectin; Q9UKJ0; -.
DR GlyGen; Q9UKJ0; 1 site.
DR iPTMnet; Q9UKJ0; -.
DR PhosphoSitePlus; Q9UKJ0; -.
DR BioMuta; PILRB; -.
DR DMDM; 74761987; -.
DR MassIVE; Q9UKJ0; -.
DR PaxDb; Q9UKJ0; -.
DR PeptideAtlas; Q9UKJ0; -.
DR PRIDE; Q9UKJ0; -.
DR Antibodypedia; 30676; 133 antibodies from 29 providers.
DR DNASU; 29990; -.
DR Ensembl; ENST00000448382.5; ENSP00000415775.1; ENSG00000121716.21. [Q9UKJ0-3]
DR Ensembl; ENST00000452089.5; ENSP00000391748.1; ENSG00000121716.21. [Q9UKJ0-1]
DR Ensembl; ENST00000609309.3; ENSP00000477365.1; ENSG00000121716.21. [Q9UKJ0-1]
DR GeneID; 29990; -.
DR KEGG; hsa:29990; -.
DR MANE-Select; ENST00000609309.3; ENSP00000477365.1; NM_178238.4; NP_839956.1.
DR UCSC; uc003uun.4; human. [Q9UKJ0-1]
DR CTD; 29990; -.
DR DisGeNET; 29990; -.
DR GeneCards; PILRB; -.
DR HGNC; HGNC:18297; PILRB.
DR HPA; ENSG00000121716; Low tissue specificity.
DR MIM; 605342; gene.
DR neXtProt; NX_Q9UKJ0; -.
DR OpenTargets; ENSG00000121716; -.
DR PharmGKB; PA134906700; -.
DR VEuPathDB; HostDB:ENSG00000121716; -.
DR eggNOG; ENOG502SUHR; Eukaryota.
DR GeneTree; ENSGT00940000163799; -.
DR HOGENOM; CLU_070832_0_0_1; -.
DR InParanoid; Q9UKJ0; -.
DR OMA; YSIDQPK; -.
DR OrthoDB; 1325787at2759; -.
DR PhylomeDB; Q9UKJ0; -.
DR TreeFam; TF338478; -.
DR PathwayCommons; Q9UKJ0; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR SignaLink; Q9UKJ0; -.
DR BioGRID-ORCS; 29990; 13 hits in 1070 CRISPR screens.
DR GeneWiki; PILRB; -.
DR GenomeRNAi; 29990; -.
DR Pharos; Q9UKJ0; Tbio.
DR PRO; PR:Q9UKJ0; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9UKJ0; protein.
DR Bgee; ENSG00000121716; Expressed in right testis and 91 other tissues.
DR ExpressionAtlas; Q9UKJ0; baseline and differential.
DR Genevisible; Q9UKJ0; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0042288; F:MHC class I protein binding; IBA:GO_Central.
DR GO; GO:0007171; P:activation of transmembrane receptor protein tyrosine kinase activity; NAS:UniProtKB.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:UniProtKB.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Glycoprotein; Immunoglobulin domain;
KW Membrane; Receptor; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..227
FT /note="Paired immunoglobulin-like type 2 receptor beta"
FT /id="PRO_0000226822"
FT TOPO_DOM 20..191
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 21..143
FT /note="Ig-like V-type"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="M -> MGRASYGGSPVGHQSSSDHPRAKTCRSPVRDGPRTLCGVPTVALSLH
FT FLREASSGSRTCGRRTSLCTSAKSSWTYRSGRLSWQSIKGTHLTITQALRQPLHRAPLL
FT PGQLCWSPRPLEKNKAM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15498874"
FT /id="VSP_017503"
FT VAR_SEQ 23..227
FT /note="GSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELAIVPNVRISWRRG
FT HFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQESGFLRISNLRKEDQSVYFCRVELDTRR
FT SGRQQLQSIKGTKLTITQAVTTTTTWRPSSTTTIAGLRVTESKGHSESWHLSLDTAIRV
FT ALAVAVLKTVILGLLCLLLLWWRRRKGSRAPSSDF -> LCEPALSELDRGSGERLPQD
FT LKPAEGGPVCVFLPSRAGHPEIREAAVAVHQGDQTHHHPGCHNHHHLEAQQHNHHSRPQ
FT GHRKQRALRIMAPKSGHCHQGCIGCRCAQNCHFGTAVPPPPVVEEKER (in
FT isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15498874,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_017504"
FT VARIANT 63
FT /note="I -> T (in dbSNP:rs11771799)"
FT /id="VAR_059406"
FT VARIANT 66
FT /note="N -> D (in dbSNP:rs11761306)"
FT /id="VAR_059407"
FT CONFLICT 63..66
FT /note="IVPN -> TAPD (in Ref. 2; CAC19193)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="Missing (in Ref. 2; CAC19193)"
FT /evidence="ECO:0000305"
FT STRAND 33..36
FT /evidence="ECO:0007829|PDB:4NFD"
FT STRAND 39..43
FT /evidence="ECO:0007829|PDB:4NFD"
FT STRAND 49..56
FT /evidence="ECO:0007829|PDB:4NFD"
FT STRAND 68..75
FT /evidence="ECO:0007829|PDB:4NFD"
FT STRAND 79..83
FT /evidence="ECO:0007829|PDB:4NFD"
FT TURN 84..87
FT /evidence="ECO:0007829|PDB:4NFD"
FT HELIX 91..93
FT /evidence="ECO:0007829|PDB:4NFD"
FT STRAND 96..100
FT /evidence="ECO:0007829|PDB:4NFD"
FT STRAND 106..112
FT /evidence="ECO:0007829|PDB:4NFD"
FT HELIX 117..119
FT /evidence="ECO:0007829|PDB:4NFD"
FT STRAND 121..134
FT /evidence="ECO:0007829|PDB:4NFD"
FT STRAND 136..140
FT /evidence="ECO:0007829|PDB:4NFD"
FT STRAND 145..149
FT /evidence="ECO:0007829|PDB:4NFD"
SQ SEQUENCE 227 AA; 25542 MW; 7FF960C60AB7EF09 CRC64;
MGRPLLLPLL LLLQPPAFLQ PGGSTGSGPS YLYGVTQPKH LSASMGGSVE IPFSFYYPWE
LAIVPNVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN WTEGQESGFL RISNLRKEDQ
SVYFCRVELD TRRSGRQQLQ SIKGTKLTIT QAVTTTTTWR PSSTTTIAGL RVTESKGHSE
SWHLSLDTAI RVALAVAVLK TVILGLLCLL LLWWRRRKGS RAPSSDF
