ID   PILT_NEIGO              Reviewed;         374 AA.
AC   Q06581;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Twitching motility protein;
GN   Name=pilT;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MS11;
RX   PubMed=8100347; DOI=10.1111/j.1365-2958.1993.tb01579.x;
RA   Lauer P., Albertson N.H., Koomey M.;
RT   "Conservation of genes encoding components of a type IV pilus assembly/two-
RT   step protein export pathway in Neisseria gonorrhoeae.";
RL   Mol. Microbiol. 8:357-368(1993).
CC   -!- FUNCTION: May be involved in pilus retraction.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GSP E family. {ECO:0000305}.
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DR   EMBL; L11719; AAA25499.1; -; Genomic_DNA.
DR   PIR; S32916; S32916.
DR   AlphaFoldDB; Q06581; -.
DR   SMR; Q06581; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   CDD; cd01131; PilT; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006321; PilT/PilU.
DR   InterPro; IPR001482; T2SS/T4SS.
DR   Pfam; PF00437; T2SSE; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01420; pilT_fam; 1.
DR   PROSITE; PS00662; T2SP_E; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Fimbrium biogenesis; Nucleotide-binding; Transport.
FT   CHAIN           1..374
FT                   /note="Twitching motility protein"
FT                   /id="PRO_0000207295"
FT   BINDING         157..164
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   374 AA;  41098 MW;  6614F5A8F5C08D4C CRC64;
     MRSSDCGAVL AWSVKMHRWP VWASCIAYSI LSLLRTSPIQ TTSGDWAIAF CTPMIRVHGD
     MRRINLPEMS AEEVGNMVTS VMNDHQRKIY QQNLEVDFSF ELPNVARFRV NAFNTGRGPA
     AVFRTIPSTV LSLEELKAPS IFQKIAESPR GMVLVTGPTG SGKSTTLAAM INYINETQPA
     HILTIEDPIE FVHQSKKSLI NQRELHQHTL SFANALSSAL REDPDVILVG EMRDPETIGL
     ALTAAETGHL VFGTLHTTGA AKTVDRIVDV FPAGEKEMVR SMLSESLTAV ISQNLLKTHD
     GNGRVASHEI LIANPAVRNL IRENKITQIN SVLQTGQASG MQTMDQSLQS LVRQGLIAPE
     AARRRAQNSE SMSF