ID   PIMG_MYCTO              Reviewed;         427 AA.
AC   P9WMZ8; L0TAF3; O53515; Q7D7E4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase;
DE            EC=2.4.1.-;
DE   AltName: Full=Alpha-D-mannose-alpha-(1-2)-mannosyltransferase;
DE   AltName: Full=Alpha-mannosyltransferase;
DE            Short=Alpha-ManT;
DE   AltName: Full=PPM-dependent mannosyltransferase;
DE   AltName: Full=Polyprenol-phosphate-mannose alpha-mannosyltransferase;
DE            Short=PPM alpha-mannosyltransferase;
GN   OrderedLocusNames=MT2236;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Responsible for the addition of alpha-(1-2) mannose branches
CC       to the linear mannan core on the biosynthetic pathway to mature
CC       lipoarabinomannan (LAM). {ECO:0000250}.
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylinositol metabolism.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 87 family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK46522.1; -; Genomic_DNA.
DR   PIR; G70936; G70936.
DR   RefSeq; WP_003411339.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMZ8; -.
DR   CAZy; GT87; Glycosyltransferase Family 87.
DR   EnsemblBacteria; AAK46522; AAK46522; MT2236.
DR   GeneID; 45426157; -.
DR   KEGG; mtc:MT2236; -.
DR   PATRIC; fig|83331.31.peg.2412; -.
DR   HOGENOM; CLU_034641_3_0_11; -.
DR   UniPathway; UPA00949; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR   GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR018584; GT87.
DR   Pfam; PF09594; GT87; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycosyltransferase; Lipid biosynthesis; Lipid metabolism;
KW   Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Transferase;
KW   Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..427
FT                   /note="Polyprenol-phosphate-mannose-dependent alpha-(1-2)-
FT                   phosphatidylinositol mannoside mannosyltransferase"
FT                   /id="PRO_0000427214"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   427 AA;  47143 MW;  C5B1A18175A661CE CRC64;
     MSAWRAPEVG SRLGRRVLWC LLWLLAGVAL GYVAWRLFGH TPYRIDIDIY QMGARAWLDG
     RPLYGGGVLF HTPIGLNLPF TYPPLAAVLF SPFAWLQMPA ASVAITVLTL VLLIASTAIV
     LTGLDAWPTS RLVPAPARLR RLWLAVLIVA PATIWLEPIS SNFAFGQINV VLMTLVIVDC
     FPRRTPWPRG LMLGLGIALK LTPAVFLLYF LLRRDGRAAL TALASFAVAT LLGFVLAWRD
     SWEYWTHTLH HTDRIGAAAL NTDQNIAGAL ARLTIGDDER FALWVAGSLL VLAATIWAMR
     RVLRAGEPTL AVICVALFGL VVSPVSWSHH WVWMLPAVLV IGLLGWRRRN VALAMLSLAG
     VVLMRWTPID LLPQHRETTA VWWRQLAGMS YVWWALAVIV VAGLTVTARM TPQRSLTRGL
     TPAPTAS