ID   A6334_ARTBC             Reviewed;         687 AA.
AC   D4AQ27;
DT   11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Putative secreted metallopeptidase {ECO:0000305};
DE            EC=3.4.24.- {ECO:0000305};
DE   Flags: Precursor;
GN   ORFNames=ARB_06334;
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION BY MASS
RP   SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC MYA-4681 / CBS 112371;
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=21919205; DOI=10.1002/pmic.201100234;
RA   Sriranganadane D., Waridel P., Salamin K., Feuermann M., Mignon B.,
RA   Staib P., Neuhaus J.M., Quadroni M., Monod M.;
RT   "Identification of novel secreted proteases during extracellular
RT   proteolysis by dermatophytes at acidic pH.";
RL   Proteomics 11:4422-4433(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21247460,
CC       ECO:0000269|PubMed:21919205}.
CC   -!- SIMILARITY: Belongs to the peptidase M10B family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ABSU01000005; EFE34571.1; -; Genomic_DNA.
DR   RefSeq; XP_003015211.1; XM_003015165.1.
DR   AlphaFoldDB; D4AQ27; -.
DR   EnsemblFungi; EFE34571; EFE34571; ARB_06334.
DR   GeneID; 9520935; -.
DR   KEGG; abe:ARB_06334; -.
DR   eggNOG; ENOG502QVPB; Eukaryota.
DR   HOGENOM; CLU_013425_0_0_1; -.
DR   OMA; IWPNAGG; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR008757; Peptidase_M6-like_domain.
DR   TIGRFAMs; TIGR03296; M6dom_TIGR03296; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Hydrolase; Metalloprotease; Protease; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..687
FT                   /note="Putative secreted metallopeptidase"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000434675"
FT   CARBOHYD        54
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        252
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        256
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        379
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   687 AA;  75039 MW;  1CF7624A26EFC302 CRC64;
     MLFTSTAVAA LSGALLIQPA LAAPNGLPSH GGSHHGPKDP FEVLDPQNWV NPDNMTWADF
     KSPPGTKWND PSRKGSIRNF NIALVNVDYP DKPFTITMAP GSDVFKNPQP GSPNVTRSQV
     PAFYRDFLNK PGKLNRGHTL HEYWMEDSNG RFGVDLTTFG VYKMPLKSYQ YGIGESMNAG
     ACPIGETCYY EIRDDALGAW RKDIGEEKAK SFELVFILSA GQDESSTWQE FGEIMFQNKE
     DVTSAFGPPP GNGTGNMTLP NYAKTRYVEW TSWASASAIW PNAGDGSSTQ AESSGMGTFA
     HELSHLLNVG DNYNNPYGKP LRRSYTGPWS MMSRGSFNGP GGPHTRWQVP PLQGGSMGSQ
     HTFHDKIRLG LTTKDSALNI SREALANSGL IVARVTARVI APKPGDLIGI HVAMDKDKSP
     KCDVNTDPYC DGNGYQNYNV EVIDRMGADS FCPDSGVMLS KTRDKAFSNY QWTIDANPQD
     IKQVDFHRPD GTPAMISLGD YRQLADALFH AGTRSGSQYE YTDKANNLQF YIIEPHRDEA
     GVLSYTTAVR YVGGKDPHKR GVKLDKNAKI TSSNTKPTDK GVTCSFTLHN TGTYNPAAGK
     AKHPQDVTAY LKSDVYRLKA TVEGRGWRVE VPNALATAEF GKTVTVSVAV GAENSAQDKA
     KVTLTATSEA DPSKFATAEC KVNKFRN