A63F_DROME
ID A63F_DROME Reviewed; 81 AA.
AC O46200; B7FNL7; Q6VBE5; Q6VBE6; Q6VBE7; Q6VBE8; Q9VZM3;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Accessory gland protein Acp63F;
DE Flags: Precursor;
GN Name=Acp63F; ORFNames=CG10852;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Canton-S; TISSUE=Male accessory gland;
RX PubMed=9474779; DOI=10.1016/s0965-1748(97)00056-8;
RA Wolfner M.F., Harada H.A., Bertram M.J., Stelick T.J., Kraus K.W.,
RA Kalb J.M., Lung Y.O., Neubaum D.M., Park M., Tram U.K.;
RT "New genes for male accessory gland proteins in Drosophila melanogaster.";
RL Insect Biochem. Mol. Biol. 27:825-834(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Zim63H-12C, Zim63H-16C, Zim63H-28C, Zim63H-30C, Zim63H-34C,
RC Zim63I-10C, Zim63I-18C, Zim63I-53C, and Zim63I-7C;
RX PubMed=11102381; DOI=10.1093/genetics/156.4.1879;
RA Begun D.J., Whitley P., Todd B.L., Waldrip-Dail H.M., Clark A.G.;
RT "Molecular population genetics of male accessory gland proteins in
RT Drosophila.";
RL Genetics 156:1879-1888(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NFS 5.1, NFS 5.2, NFS 5.3, NFS 5.4, NFS 6.1, NFS 6.2, NFS 6.3,
RC NFS 6.4, NFS 7.8, SFS 1.1, SFS 1.2, SFS 1.3, SFS 1.4, SFS 2.2, SFS 2.3,
RC SFS 2.4, SFS 3.1, SFS 3.2, SFS 3.3, and SFS 3.4;
RX PubMed=14761057; DOI=10.1554/03-335;
RA Panhuis T.M., Swanson W.J., Nunney L.;
RT "Population genetics of accessory gland proteins and sexual behavior in
RT Drosophila melanogaster populations from Evolution Canyon.";
RL Evolution 57:2785-2791(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for physiological and behavioral changes in mated
CC female flies. {ECO:0000269|PubMed:9474779}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Main cells of accessory gland and seminal fluid.
CC {ECO:0000269|PubMed:9474779}.
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DR EMBL; U85761; AAB96385.1; -; mRNA.
DR EMBL; AY010618; AAG37390.1; -; Genomic_DNA.
DR EMBL; AY010619; AAG37391.1; -; Genomic_DNA.
DR EMBL; AY010620; AAG37392.1; -; Genomic_DNA.
DR EMBL; AY010621; AAG37393.1; -; Genomic_DNA.
DR EMBL; AY010622; AAG37394.1; -; Genomic_DNA.
DR EMBL; AY010623; AAG37395.1; -; Genomic_DNA.
DR EMBL; AY010624; AAG37396.1; -; Genomic_DNA.
DR EMBL; AY010625; AAG37397.1; -; Genomic_DNA.
DR EMBL; AY010626; AAG37398.1; -; Genomic_DNA.
DR EMBL; AY344345; AAR05064.1; -; Genomic_DNA.
DR EMBL; AY344346; AAR05065.1; -; Genomic_DNA.
DR EMBL; AY344347; AAR05066.1; -; Genomic_DNA.
DR EMBL; AY344348; AAR05067.1; -; Genomic_DNA.
DR EMBL; AY344349; AAR05068.1; -; Genomic_DNA.
DR EMBL; AY344350; AAR05069.1; -; Genomic_DNA.
DR EMBL; AY344351; AAR05070.1; -; Genomic_DNA.
DR EMBL; AY344352; AAR05071.1; -; Genomic_DNA.
DR EMBL; AY344353; AAR05072.1; -; Genomic_DNA.
DR EMBL; AY344354; AAR05073.1; -; Genomic_DNA.
DR EMBL; AY344355; AAR05074.1; -; Genomic_DNA.
DR EMBL; AY344356; AAR05075.1; -; Genomic_DNA.
DR EMBL; AY344357; AAR05076.1; -; Genomic_DNA.
DR EMBL; AY344358; AAR05077.1; -; Genomic_DNA.
DR EMBL; AY344359; AAR05078.1; -; Genomic_DNA.
DR EMBL; AY344360; AAR05079.1; -; Genomic_DNA.
DR EMBL; AY344361; AAR05080.1; -; Genomic_DNA.
DR EMBL; AY344362; AAR05081.1; -; Genomic_DNA.
DR EMBL; AY344363; AAR05082.1; -; Genomic_DNA.
DR EMBL; AY344364; AAR05083.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF47797.2; -; Genomic_DNA.
DR EMBL; BT053707; ACK77625.1; -; mRNA.
DR RefSeq; NP_001303386.1; NM_001316457.1.
DR RefSeq; NP_523906.2; NM_079182.3.
DR AlphaFoldDB; O46200; -.
DR BioGRID; 63938; 3.
DR STRING; 7227.FBpp0073038; -.
DR PaxDb; O46200; -.
DR DNASU; 38448; -.
DR EnsemblMetazoa; FBtr0073182; FBpp0073038; FBgn0015585.
DR EnsemblMetazoa; FBtr0346805; FBpp0312380; FBgn0015585.
DR GeneID; 38448; -.
DR KEGG; dme:Dmel_CG10852; -.
DR CTD; 38448; -.
DR FlyBase; FBgn0015585; Acp63F.
DR VEuPathDB; VectorBase:FBgn0015585; -.
DR HOGENOM; CLU_2576336_0_0_1; -.
DR OMA; CGILPDC; -.
DR OrthoDB; 1641424at2759; -.
DR PhylomeDB; O46200; -.
DR BioGRID-ORCS; 38448; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38448; -.
DR PRO; PR:O46200; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0015585; Expressed in male reproductive gland and 18 other tissues.
DR ExpressionAtlas; O46200; baseline and differential.
DR Genevisible; O46200; DM.
DR GO; GO:0005615; C:extracellular space; HDA:FlyBase.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0019953; P:sexual reproduction; HEP:FlyBase.
PE 2: Evidence at transcript level;
KW Behavior; Reference proteome; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..81
FT /note="Accessory gland protein Acp63F"
FT /id="PRO_0000020585"
FT VARIANT 39
FT /note="N -> S (in strain: SFS 3.4)"
FT VARIANT 49
FT /note="K -> N (in strain: Canton-S, NFS 5.1, NFS 5.2, NFS
FT 5.3, NFS 5.4, NFS 6.1, NFS 6.2, NFS 6.3, NFS 6.4, NFS 7.8,
FT SFS 1.1, SFS 1.2, SFS 1.3, SFS 1.4, SFS 2.2, SFS 2.3, SFS
FT 2.4, SFS 3.1, SFS 3.2, SFS 3.3, SFS 3.4, Zim63H-12C,
FT Zim63H-16C, Zim63H-28C, Zim63H-34C, Zim63I-10C, Zim63I-18C,
FT Zim63I-53C and Zim63I-7C)"
FT VARIANT 72
FT /note="L -> V (in strain: Zim63H-16C, Zim63H-34C and
FT Zim63I-7C)"
FT VARIANT 73..74
FT /note="HG -> MA (in strain: Zim63H-30C)"
FT VARIANT 73
FT /note="H -> Q (in strain: Zim63H-16C and Zim63H-34C)"
FT VARIANT 75
FT /note="K -> E (in strain: Zim63H-16C)"
FT VARIANT 76
FT /note="P -> T (in strain: Zim63I-7C)"
SQ SEQUENCE 81 AA; 8983 MW; 0C53080311BA285B CRC64;
MKAIIVFILF ISSVHAMSKC NQAIYLNLDP HCGILPDCNL DGPNPSYLKR VSCERKENGK
PGFIELIPGK CLHGKPRCSL K
