ASTD1_CAUVC
ID ASTD1_CAUVC Reviewed; 472 AA.
AC Q9AAL5;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_01174};
DE EC=1.2.1.71 {ECO:0000255|HAMAP-Rule:MF_01174};
DE AltName: Full=Succinylglutamic semialdehyde dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_01174};
DE Short=SGSD 1 {ECO:0000255|HAMAP-Rule:MF_01174};
GN Name=astD1 {ECO:0000255|HAMAP-Rule:MF_01174}; OrderedLocusNames=CC_0582;
OS Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=190650;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=11259647; DOI=10.1073/pnas.061029298;
RA Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT "Complete genome sequence of Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC -!- FUNCTION: Catalyzes the NAD-dependent reduction of succinylglutamate
CC semialdehyde into succinylglutamate. {ECO:0000255|HAMAP-Rule:MF_01174}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = 2 H(+)
CC + N-succinyl-L-glutamate + NADH; Xref=Rhea:RHEA:10812,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58520, ChEBI:CHEBI:58763; EC=1.2.1.71;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01174};
CC -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC {ECO:0000255|HAMAP-Rule:MF_01174}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01174}.
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DR EMBL; AE005673; AAK22568.1; -; Genomic_DNA.
DR PIR; D87321; D87321.
DR RefSeq; NP_419400.1; NC_002696.2.
DR RefSeq; WP_010918469.1; NC_002696.2.
DR AlphaFoldDB; Q9AAL5; -.
DR SMR; Q9AAL5; -.
DR STRING; 190650.CC_0582; -.
DR EnsemblBacteria; AAK22568; AAK22568; CC_0582.
DR KEGG; ccr:CC_0582; -.
DR PATRIC; fig|190650.5.peg.594; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_1_0_5; -.
DR OMA; TAGICTD; -.
DR BioCyc; CAULO:CC0582-MON; -.
DR UniPathway; UPA00185; UER00282.
DR Proteomes; UP000001816; Chromosome.
DR GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:UniProtKB-UniRule.
DR GO; GO:0019545; P:arginine catabolic process to succinate; IEA:UniProtKB-UniPathway.
DR CDD; cd07095; ALDH_SGSD_AstD; 1.
DR Gene3D; 3.40.309.10; -; 1.
DR Gene3D; 3.40.605.10; -; 1.
DR HAMAP; MF_01174; Aldedh_AstD; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR PANTHER; PTHR11699:SF197; PTHR11699:SF197; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; SSF53720; 1.
DR TIGRFAMs; TIGR03240; arg_catab_astD; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Arginine metabolism; NAD; Oxidoreductase; Reference proteome.
FT CHAIN 1..472
FT /note="N-succinylglutamate 5-semialdehyde dehydrogenase 1"
FT /id="PRO_0000262394"
FT ACT_SITE 232
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01174"
FT ACT_SITE 266
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01174"
FT BINDING 209..214
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01174"
SQ SEQUENCE 472 AA; 49811 MW; 28E7C4A5FF80EF2F CRC64;
MSASRLISRD PYTGEAIADF AVNDARSIDA ACHSARAAFA EWAMTPLAER RAIALRFAET
VRARREEIAT LIARETGKPM WEALTEADSV AAKVAISIRA QDERAGERSE PMADATARLA
HRPHGVLAVI GPFNFPMHLA NGHIVPALLA GNAVVFKPSE KTPACGQLMG ELWRAAGLPD
HVLTIVIGGG EAGEALVRHE ALDGVLFTGG VQAGRAIHRA LADAPHKILA LELGGNAPLV
VWDVADIEAA AHLIVQSAYV TAGQRCTCAR RLILPEGARG DALLEALTML MDRLVIGGPF
QSPAPFMGPV IDAHAAAQVL AAQDRMTADG GRPLRLAAVR EARSALLSPG LIELTDAPLR
DEEIFGPLLQ VRRAADFDAA LALANATRFG LAAGLISDDE ALYRRFWTSV RAGIVNWNRP
TTGASSAAPF GGVGGSGNHR PSAYYAADYS AYPVAGLESP SPVYRLPIGL NP
