ASTD2_CAUVC
ID ASTD2_CAUVC Reviewed; 485 AA.
AC Q9A7W2;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_01174};
DE EC=1.2.1.71 {ECO:0000255|HAMAP-Rule:MF_01174};
DE AltName: Full=Succinylglutamic semialdehyde dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_01174};
DE Short=SGSD 2 {ECO:0000255|HAMAP-Rule:MF_01174};
GN Name=astD2 {ECO:0000255|HAMAP-Rule:MF_01174}; OrderedLocusNames=CC_1607;
OS Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=190650;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=11259647; DOI=10.1073/pnas.061029298;
RA Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT "Complete genome sequence of Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC -!- FUNCTION: Catalyzes the NAD-dependent reduction of succinylglutamate
CC semialdehyde into succinylglutamate. {ECO:0000255|HAMAP-Rule:MF_01174}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = 2 H(+)
CC + N-succinyl-L-glutamate + NADH; Xref=Rhea:RHEA:10812,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58520, ChEBI:CHEBI:58763; EC=1.2.1.71;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01174};
CC -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC {ECO:0000255|HAMAP-Rule:MF_01174}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01174}.
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DR EMBL; AE005673; AAK23586.1; -; Genomic_DNA.
DR PIR; F87448; F87448.
DR RefSeq; NP_420418.1; NC_002696.2.
DR RefSeq; WP_010919481.1; NC_002696.2.
DR AlphaFoldDB; Q9A7W2; -.
DR SMR; Q9A7W2; -.
DR STRING; 190650.CC_1607; -.
DR EnsemblBacteria; AAK23586; AAK23586; CC_1607.
DR KEGG; ccr:CC_1607; -.
DR PATRIC; fig|190650.5.peg.1634; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_1_0_5; -.
DR OMA; NWNKQLT; -.
DR BioCyc; CAULO:CC1607-MON; -.
DR UniPathway; UPA00185; UER00282.
DR Proteomes; UP000001816; Chromosome.
DR GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:UniProtKB-UniRule.
DR GO; GO:0019545; P:arginine catabolic process to succinate; IEA:UniProtKB-UniPathway.
DR CDD; cd07095; ALDH_SGSD_AstD; 1.
DR Gene3D; 3.40.309.10; -; 1.
DR Gene3D; 3.40.605.10; -; 1.
DR HAMAP; MF_01174; Aldedh_AstD; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR PANTHER; PTHR11699:SF197; PTHR11699:SF197; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; SSF53720; 1.
DR TIGRFAMs; TIGR03240; arg_catab_astD; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Arginine metabolism; NAD; Oxidoreductase; Reference proteome.
FT CHAIN 1..485
FT /note="N-succinylglutamate 5-semialdehyde dehydrogenase 2"
FT /id="PRO_0000262395"
FT ACT_SITE 244
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01174"
FT ACT_SITE 279
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01174"
FT BINDING 221..226
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01174"
SQ SEQUENCE 485 AA; 50840 MW; BFD41A4A04E231B0 CRC64;
MSGGLFIDGK WRAGQGAGLS STDPATGEDV WSAATATPAD VADAVAAARK AFPAWADRPR
EERIAILRRY KDILVERAAP YAEALSRETG KALWETRAEL ASMAGKVDLS IRAYDERTGV
TENAMPFGRA VLRHRAHGVM AVLGPFNFPG HLPNGHIVPA LLAGDTVVFK PSEETPLAGQ
LMVEALEAAG APAGVVNLVQ GGRETGQALI AQDIDGLLFT GSAAAGTYFR RYFADRPDVI
LALELGGNNP LVVWNADDAP EAVAALIVQS AFITTGQRCS CARRLIVPDD ASGAAIIEAT
VALAERLVIG AWNAENEPFM GPLISGRAAK AAREVASATP GKTILALDGV AGLGDAFLKP
GIVDVTGLET PDEELFAPLL QVRRVSSFDE ALAAANATRY GLSAGLISNE SELWDKFLSR
IRAGVVNWNR PTTGAAGSMP FGGLGASGNH RPSAYYAADY CAYPVASFEA SMVVDTLKDI
KGLKA
