ID   PIN2_CAEEL              Reviewed;         330 AA.
AC   Q19157; H9G2V0; H9G2V1;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=LIM domain-containing protein pin-2;
GN   Name=pin-2; ORFNames=F07C6.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=9885243; DOI=10.1083/jcb.144.1.45;
RA   Hobert O., Moerman D.G., Clark K.A., Beckerle M.C., Ruvkun G.;
RT   "A conserved LIM protein that affects muscular adherens junction integrity
RT   and mechanosensory function in Caenorhabditis elegans.";
RL   J. Cell Biol. 144:45-57(1999).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9885243}. Nucleus
CC       {ECO:0000269|PubMed:9885243}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=Q19157-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q19157-2; Sequence=VSP_044155;
CC   -!- TISSUE SPECIFICITY: Expressed in neurons and intestine.
CC       {ECO:0000269|PubMed:9885243}.
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DR   EMBL; Z69659; CCG28057.1; -; Genomic_DNA.
DR   EMBL; Z69659; CCG28058.1; -; Genomic_DNA.
DR   PIR; T20546; T20546.
DR   RefSeq; NP_001255672.1; NM_001268743.1. [Q19157-1]
DR   RefSeq; NP_001255673.1; NM_001268744.1. [Q19157-2]
DR   AlphaFoldDB; Q19157; -.
DR   SMR; Q19157; -.
DR   STRING; 6239.F07C6.1a; -.
DR   PaxDb; Q19157; -.
DR   PeptideAtlas; Q19157; -.
DR   EnsemblMetazoa; F07C6.1a.1; F07C6.1a.1; WBGene00004030. [Q19157-1]
DR   EnsemblMetazoa; F07C6.1b.1; F07C6.1b.1; WBGene00004030. [Q19157-2]
DR   GeneID; 178234; -.
DR   KEGG; cel:CELE_F07C6.1; -.
DR   UCSC; F07C6.1; c. elegans. [Q19157-1]
DR   CTD; 178234; -.
DR   WormBase; F07C6.1a; CE47311; WBGene00004030; pin-2. [Q19157-1]
DR   WormBase; F07C6.1b; CE47192; WBGene00004030; pin-2. [Q19157-2]
DR   eggNOG; KOG2272; Eukaryota.
DR   GeneTree; ENSGT00940000153518; -.
DR   HOGENOM; CLU_001357_0_0_1; -.
DR   InParanoid; Q19157; -.
DR   OMA; EGRIYCE; -.
DR   OrthoDB; 1593918at2759; -.
DR   PhylomeDB; Q19157; -.
DR   Reactome; R-CEL-446353; Cell-extracellular matrix interactions.
DR   PRO; PR:Q19157; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00004030; Expressed in embryo and 4 other tissues.
DR   GO; GO:0030424; C:axon; IDA:WormBase.
DR   GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0043196; C:varicosity; IDA:WormBase.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   GO; GO:0045216; P:cell-cell junction organization; IBA:GO_Central.
DR   GO; GO:2001046; P:positive regulation of integrin-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IBA:GO_Central.
DR   InterPro; IPR017351; PINCH_1-like.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24210; PTHR24210; 1.
DR   Pfam; PF00412; LIM; 4.
DR   PIRSF; PIRSF038003; PINCH; 1.
DR   SMART; SM00132; LIM; 5.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 4.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 5.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; LIM domain; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Zinc.
FT   CHAIN           1..330
FT                   /note="LIM domain-containing protein pin-2"
FT                   /id="PRO_0000075887"
FT   DOMAIN          21..73
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          82..132
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          144..194
FT                   /note="LIM zinc-binding 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          202..255
FT                   /note="LIM zinc-binding 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          264..315
FT                   /note="LIM zinc-binding 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   VAR_SEQ         1..274
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_044155"
SQ   SEQUENCE   330 AA;  38741 MW;  E3F4637BB75122ED CRC64;
     MMTNAAQITK QRNSGKRHRA CERCREQFEL NEPYFLLGAS SWHMRCFLCA QCMDPLVGTT
     YFQFENRIYC EHDFKTLYAP VCAKCNEFVI GQVVHSSNNS YHLACFTCDE CNVHLNSQIA
     YRYQGTILCF LCNQKKPKMR IYNCNKCKQH VDNSDLLTYQ ENPYHAYHFK CTTCKKVLES
     DARTIKDDLF CPRCFDFKCE VCFDCKKVID PQVEQSIFTM NKHWHTDHFR CATCARPFFG
     HEHYEKNGKA YCRDDFLELI GHHCFICDRN VGGGMVHVFG KAFCPECYRC RGCDKVLHYK
     DKVMELDLMP LCKKCLGNKT FQKALKYKSL