PIN4_DANRE
ID PIN4_DANRE Reviewed; 128 AA.
AC Q503Y7;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4;
DE EC=5.2.1.8;
DE AltName: Full=Parvulin-14;
DE Short=Par14;
DE AltName: Full=Peptidyl-prolyl cis-trans isomerase Pin4;
DE Short=PPIase Pin4;
DE AltName: Full=Rotamase Pin4;
GN Name=pin4; ORFNames=zgc:110008;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved as a ribosomal RNA processing factor in
CC ribosome biogenesis. Binds to DNA (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PpiC/parvulin rotamase family. PIN4
CC subfamily. {ECO:0000305}.
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DR EMBL; BC095126; AAH95126.1; -; mRNA.
DR RefSeq; NP_001018389.1; NM_001020553.1.
DR AlphaFoldDB; Q503Y7; -.
DR SMR; Q503Y7; -.
DR STRING; 7955.ENSDARP00000023444; -.
DR PaxDb; Q503Y7; -.
DR Ensembl; ENSDART00000026846; ENSDARP00000023444; ENSDARG00000004527.
DR GeneID; 553574; -.
DR KEGG; dre:553574; -.
DR CTD; 5303; -.
DR ZFIN; ZDB-GENE-050522-117; pin4.
DR eggNOG; KOG3258; Eukaryota.
DR GeneTree; ENSGT00510000047029; -.
DR HOGENOM; CLU_090028_2_1_1; -.
DR InParanoid; Q503Y7; -.
DR OMA; AMSINVR; -.
DR OrthoDB; 1397633at2759; -.
DR PhylomeDB; Q503Y7; -.
DR TreeFam; TF101102; -.
DR PRO; PR:Q503Y7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 14.
DR Bgee; ENSDARG00000004527; Expressed in tail and 24 other tissues.
DR ExpressionAtlas; Q503Y7; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR Gene3D; 3.10.50.40; -; 1.
DR InterPro; IPR043323; PIN4.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR000297; PPIase_PpiC.
DR PANTHER; PTHR45995; PTHR45995; 1.
DR PROSITE; PS50198; PPIC_PPIASE_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; DNA-binding; Isomerase; Nucleus;
KW Reference proteome; Rotamase.
FT CHAIN 1..128
FT /note="Peptidyl-prolyl cis-trans isomerase NIMA-interacting
FT 4"
FT /id="PRO_0000379926"
FT DOMAIN 32..126
FT /note="PpiC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00278"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 128 AA; 13664 MW; 214ED4DD20755C70 CRC64;
MPPKGKGGKG AKGAAASGSG DSDKKEKAQK GGTAVKVRHI LCEKHGKCME AMEKIKSGMR
FSEVAAQYSE DKARQGGDLG WMTRGSMVGP FQDAAFALPI STMDKPVYTD PPVKTKFGYH
IIMVEGKK
