PINLY_HUMAN
ID PINLY_HUMAN Reviewed; 204 AA.
AC A6NC86; B7Z457; O95053;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 3.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein;
DE Flags: Precursor;
GN Name=PINLYP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=A6NC86-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NC86-2; Sequence=VSP_044189;
CC Name=3;
CC IsoId=A6NC86-3; Sequence=VSP_044189, VSP_044190;
CC Name=4;
CC IsoId=A6NC86-4; Sequence=VSP_044188;
CC -!- SIMILARITY: Belongs to the CNF-like-inhibitor family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC99796.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK296854; BAH12443.1; -; mRNA.
DR EMBL; AC006276; AAC99796.1; ALT_SEQ; Genomic_DNA.
DR EMBL; L34079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC071811; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS58667.1; -. [A6NC86-4]
DR CCDS; CCDS74385.1; -. [A6NC86-1]
DR RefSeq; NP_001180550.1; NM_001193621.1. [A6NC86-1]
DR RefSeq; NP_001180551.1; NM_001193622.1. [A6NC86-4]
DR RefSeq; NP_001308053.1; NM_001321124.1. [A6NC86-4]
DR RefSeq; XP_011525272.1; XM_011526970.2.
DR RefSeq; XP_011525273.1; XM_011526971.2. [A6NC86-4]
DR AlphaFoldDB; A6NC86; -.
DR SMR; A6NC86; -.
DR STRING; 9606.ENSP00000479240; -.
DR GlyGen; A6NC86; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; A6NC86; -.
DR PhosphoSitePlus; A6NC86; -.
DR BioMuta; PINLYP; -.
DR MassIVE; A6NC86; -.
DR PaxDb; A6NC86; -.
DR PeptideAtlas; A6NC86; -.
DR PRIDE; A6NC86; -.
DR Antibodypedia; 70850; 4 antibodies from 4 providers.
DR DNASU; 390940; -.
DR Ensembl; ENST00000562255.5; ENSP00000457623.1; ENSG00000234465.11. [A6NC86-4]
DR Ensembl; ENST00000562365.2; ENSP00000456310.1; ENSG00000234465.11. [A6NC86-4]
DR Ensembl; ENST00000569031.6; ENSP00000457369.1; ENSG00000234465.11. [A6NC86-4]
DR Ensembl; ENST00000599207.6; ENSP00000469886.1; ENSG00000234465.11. [A6NC86-1]
DR Ensembl; ENST00000612042.4; ENSP00000479240.1; ENSG00000234465.11. [A6NC86-2]
DR GeneID; 390940; -.
DR KEGG; hsa:390940; -.
DR MANE-Select; ENST00000599207.6; ENSP00000469886.1; NM_001193621.3; NP_001180550.2.
DR UCSC; uc002owu.3; human. [A6NC86-1]
DR CTD; 390940; -.
DR DisGeNET; 390940; -.
DR GeneCards; PINLYP; -.
DR HGNC; HGNC:44206; PINLYP.
DR HPA; ENSG00000234465; Low tissue specificity.
DR neXtProt; NX_A6NC86; -.
DR OpenTargets; ENSG00000234465; -.
DR VEuPathDB; HostDB:ENSG00000234465; -.
DR eggNOG; ENOG502SRI1; Eukaryota.
DR GeneTree; ENSGT00730000111229; -.
DR HOGENOM; CLU_094248_0_0_1; -.
DR InParanoid; A6NC86; -.
DR OMA; GQETHCV; -.
DR OrthoDB; 1485195at2759; -.
DR PhylomeDB; A6NC86; -.
DR PathwayCommons; A6NC86; -.
DR BioGRID-ORCS; 390940; 16 hits in 1065 CRISPR screens.
DR ChiTaRS; PINLYP; human.
DR GenomeRNAi; 390940; -.
DR Pharos; A6NC86; Tdark.
DR PRO; PR:A6NC86; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NC86; protein.
DR Bgee; ENSG00000234465; Expressed in ventricular zone and 129 other tissues.
DR Genevisible; A6NC86; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004859; F:phospholipase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.10.60.10; -; 2.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR004126; PLipase_A2_inh.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF02988; PLA2_inh; 1.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SUPFAM; SSF57302; SSF57302; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..204
FT /note="phospholipase A2 inhibitor and Ly6/PLAUR domain-
FT containing protein"
FT /id="PRO_0000332737"
FT DOMAIN 27..117
FT /note="UPAR/Ly6"
FT DISULFID 29..53
FT /evidence="ECO:0000250"
FT DISULFID 32..39
FT /evidence="ECO:0000250"
FT DISULFID 46..74
FT /evidence="ECO:0000250"
FT DISULFID 80..101
FT /evidence="ECO:0000250"
FT DISULFID 102..107
FT /evidence="ECO:0000250"
FT DISULFID 126..151
FT /evidence="ECO:0000250"
FT DISULFID 144..172
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..88
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044188"
FT VAR_SEQ 1
FT /note="M -> MWVQTHPSSASYKSWGPGTADTHTM (in isoform 2 and
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044189"
FT VAR_SEQ 63..204
FT /note="KGKELVHTYKGCIRSQDCYSGVISTTMGPKDHMVTSSFCCQSDGCNSAFLSV
FT PLTNLTENGLMCPACTASFRDKCMGPMTHCTGKENHCVSLSGHVQAGIFKPRFAMRGCA
FT TESMCFTKPGAEVPTGTNVLFLHHIECTHSP -> SKRMWPGTWWGGGVYLQGGRDYHA
FT EGGSSRFSRRERGKKSVESRKEGKTIMRWREQK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044190"
FT CONFLICT A6NC86-3:6
FT /note="H -> R (in Ref. 1; BAH12443)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 204 AA; 21926 MW; 9F49DFAF0AFB9868 CRC64;
MRLSRRPETF LLAFVLLCTL LGLGCPLHCE ICTAAGSRCH GQMKTCSSDK DTCVLLVGKA
TSKGKELVHT YKGCIRSQDC YSGVISTTMG PKDHMVTSSF CCQSDGCNSA FLSVPLTNLT
ENGLMCPACT ASFRDKCMGP MTHCTGKENH CVSLSGHVQA GIFKPRFAMR GCATESMCFT
KPGAEVPTGT NVLFLHHIEC THSP
