PINLY_MOUSE
ID PINLY_MOUSE Reviewed; 212 AA.
AC Q9CQD7; Q9D6V5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein;
DE Flags: Precursor;
GN Name=Pinlyp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CNF-like-inhibitor family. {ECO:0000305}.
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DR EMBL; AK009589; BAB26378.1; -; mRNA.
DR EMBL; AK009604; BAB26386.1; -; mRNA.
DR EMBL; AK009778; BAB26498.1; -; mRNA.
DR EMBL; AK009924; BAB26587.1; -; mRNA.
DR EMBL; BC145686; AAI45687.1; -; mRNA.
DR CCDS; CCDS20954.1; -.
DR RefSeq; NP_001032220.1; NM_001037143.2.
DR RefSeq; XP_006540337.1; XM_006540274.3.
DR AlphaFoldDB; Q9CQD7; -.
DR SMR; Q9CQD7; -.
DR STRING; 10090.ENSMUSP00000011776; -.
DR iPTMnet; Q9CQD7; -.
DR PhosphoSitePlus; Q9CQD7; -.
DR PaxDb; Q9CQD7; -.
DR PRIDE; Q9CQD7; -.
DR ProteomicsDB; 288166; -.
DR Antibodypedia; 70850; 4 antibodies from 4 providers.
DR Ensembl; ENSMUST00000011776; ENSMUSP00000011776; ENSMUSG00000011632.
DR GeneID; 641361; -.
DR KEGG; mmu:641361; -.
DR UCSC; uc009fpw.1; mouse.
DR CTD; 390940; -.
DR MGI; MGI:3615324; Pinlyp.
DR VEuPathDB; HostDB:ENSMUSG00000011632; -.
DR eggNOG; ENOG502SRI1; Eukaryota.
DR GeneTree; ENSGT00730000111229; -.
DR HOGENOM; CLU_094248_0_0_1; -.
DR InParanoid; Q9CQD7; -.
DR OMA; GQETHCV; -.
DR OrthoDB; 1485195at2759; -.
DR PhylomeDB; Q9CQD7; -.
DR TreeFam; TF352648; -.
DR BioGRID-ORCS; 641361; 4 hits in 70 CRISPR screens.
DR ChiTaRS; Pinlyp; mouse.
DR PRO; PR:Q9CQD7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9CQD7; protein.
DR Bgee; ENSMUSG00000011632; Expressed in lip and 27 other tissues.
DR ExpressionAtlas; Q9CQD7; baseline and differential.
DR Genevisible; Q9CQD7; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004859; F:phospholipase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.10.60.10; -; 2.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR004126; PLipase_A2_inh.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF02988; PLA2_inh; 1.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SUPFAM; SSF57302; SSF57302; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..212
FT /note="phospholipase A2 inhibitor and Ly6/PLAUR domain-
FT containing protein"
FT /id="PRO_0000332738"
FT DOMAIN 27..117
FT /note="UPAR/Ly6"
FT DISULFID 29..53
FT /evidence="ECO:0000250"
FT DISULFID 32..39
FT /evidence="ECO:0000250"
FT DISULFID 46..74
FT /evidence="ECO:0000250"
FT DISULFID 80..101
FT /evidence="ECO:0000250"
FT DISULFID 102..107
FT /evidence="ECO:0000250"
FT DISULFID 126..152
FT /evidence="ECO:0000250"
FT DISULFID 145..173
FT /evidence="ECO:0000250"
FT CONFLICT 5
FT /note="R -> K (in Ref. 1; BAB26587)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 212 AA; 22819 MW; 9AE665524E2A80BA CRC64;
MILFRRHRTF LLAFTLLCTL LGLGCPLTCE VCKGSGHTCS GKMKTCEDGK DACVVLVSES
STKGRKSVNT FKACMKYKDC YSGFVSTTMT PSDYMVSNAH CCQSDGCNSG SVPPPLNNRT
ENGLMCPSCI APFQETCPGT QAARCVGRET HCIYFAGNVQ AGIIHTKFAT RGCATESACH
TKAGAEVPSA FYLYFLRRAD CLPAPYPPGR GE
