PINO_DROME
ID PINO_DROME Reviewed; 249 AA.
AC Q9VPW8; Q8T0A4; Q9VPW7;
DT 06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Protein pinocchio {ECO:0000303|PubMed:15719418};
GN Name=Pino {ECO:0000312|FlyBase:FBgn0016926};
GN Synonyms=smi21F {ECO:0000303|PubMed:15719418};
GN ORFNames=CG4710 {ECO:0000312|FlyBase:FBgn0016926};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL39592.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL39592.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAL39592.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000312|EMBL:AFH97150.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC STRAIN=Berkeley {ECO:0000312|EMBL:AFH97150.1};
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=15719418; DOI=10.1002/neu.20123;
RA Rollmann S.M., Mackay T.F., Anholt R.R.;
RT "Pinocchio, a novel protein expressed in the antenna, contributes to
RT olfactory behavior in Drosophila melanogaster.";
RL J. Neurobiol. 63:146-158(2005).
CC -!- FUNCTION: Plays a role in olfaction. {ECO:0000269|PubMed:15719418}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=B {ECO:0000312|FlyBase:FBgn0016926};
CC IsoId=Q9VPW8-1; Sequence=Displayed;
CC Name=A {ECO:0000312|FlyBase:FBgn0016926}; Synonyms=C
CC {ECO:0000312|FlyBase:FBgn0016926};
CC IsoId=Q9VPW8-2; Sequence=VSP_058426;
CC -!- TISSUE SPECIFICITY: Expressed in the third antennal segment.
CC {ECO:0000269|PubMed:15719418}.
CC -!- DISRUPTION PHENOTYPE: Reduced attractant response to some odorants.
CC {ECO:0000269|PubMed:15719418}.
CC -!- SIMILARITY: Belongs to the pinocchio family. {ECO:0000305}.
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DR EMBL; AE014134; AAF51417.1; -; Genomic_DNA.
DR EMBL; AE014134; AAF51418.1; -; Genomic_DNA.
DR EMBL; AE014134; AGB92391.1; -; Genomic_DNA.
DR EMBL; AY069447; AAL39592.1; -; mRNA.
DR EMBL; BT133460; AFH97150.1; -; mRNA.
DR RefSeq; NP_001259854.1; NM_001272925.1. [Q9VPW8-2]
DR RefSeq; NP_608568.1; NM_134724.3. [Q9VPW8-2]
DR RefSeq; NP_722679.1; NM_164405.2. [Q9VPW8-1]
DR AlphaFoldDB; Q9VPW8; -.
DR IntAct; Q9VPW8; 4.
DR STRING; 7227.FBpp0077652; -.
DR PaxDb; Q9VPW8; -.
DR DNASU; 33288; -.
DR EnsemblMetazoa; FBtr0077987; FBpp0077652; FBgn0016926. [Q9VPW8-1]
DR EnsemblMetazoa; FBtr0077988; FBpp0077653; FBgn0016926. [Q9VPW8-2]
DR EnsemblMetazoa; FBtr0332272; FBpp0304561; FBgn0016926. [Q9VPW8-2]
DR GeneID; 33288; -.
DR KEGG; dme:Dmel_CG4710; -.
DR UCSC; CG4710-RA; d. melanogaster.
DR UCSC; CG4710-RB; d. melanogaster. [Q9VPW8-1]
DR CTD; 33288; -.
DR FlyBase; FBgn0016926; Pino.
DR VEuPathDB; VectorBase:FBgn0016926; -.
DR eggNOG; ENOG502S4EZ; Eukaryota.
DR InParanoid; Q9VPW8; -.
DR OMA; CGKARWL; -.
DR PhylomeDB; Q9VPW8; -.
DR BioGRID-ORCS; 33288; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33288; -.
DR PRO; PR:Q9VPW8; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0016926; Expressed in crop (Drosophila) and 44 other tissues.
DR ExpressionAtlas; Q9VPW8; baseline and differential.
DR GO; GO:0042048; P:olfactory behavior; IMP:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Olfaction; Reference proteome;
KW Sensory transduction.
FT CHAIN 1..249
FT /note="Protein pinocchio"
FT /id="PRO_0000436846"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 218..238
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..78
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000305"
FT /id="VSP_058426"
SQ SEQUENCE 249 AA; 26306 MW; 7FA32B6D234CA84D CRC64;
MKTGSNNNHI SASSSSSNNN NNSSLVQQQQ QRSTTSVSVS SSHIVTEWED GIIFDVDDPD
FCNLATDKLN FIVPSAANMS IASVHGPQIA DICSPLSHHN LGLSASLPDL VGSPLEISMD
NVLTIEELRQ HMGSCFTCGV SWTDDHVSLD CSECGGYSLE RPCPLCDGQC GVQWKRDFAM
SHACSQARWV GVCISYPEVV AGVQLPVGAG AGAATSCAAA AANQLRLAQE LCSRLEQLST
STASKSGRI
