ID   PINP1_PINPI             Reviewed;         164 AA.
AC   A0A0K3AVY3;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   11-NOV-2015, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=2S albumin seed storage protein PINP1 {ECO:0000305};
DE   AltName: Allergen=Pin p 1 {ECO:0000303|PubMed:27211622};
DE   Flags: Precursor;
GN   Name=PINP1 {ECO:0000303|PubMed:27211622};
OS   Pinus pinea (Italian stone pine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Pinopsida; Pinidae; Conifers I; Pinales; Pinaceae; Pinus;
OC   Pinus subgen. Pinus.
OX   NCBI_TaxID=3346;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, ALLERGEN,
RP   AND GLYCOSYLATION AT ASN-138.
RX   PubMed=27211622; DOI=10.1016/j.foodchem.2016.04.068;
RA   Cabanillas B., Crespo J.F., Maleki S.J., Rodriguez J., Novak N.;
RT   "Pin p 1 is a major allergen in pine nut and the first food allergen
RT   described in the plant group of gymnosperms.";
RL   Food Chem. 210:70-77(2016).
CC   -!- ALLERGEN: Causes an allergic reaction in human (PubMed:27211622). Binds
CC       to IgE of patients allergic to pine nut (PubMed:27211622). Causes
CC       activation of basophils sensitized with IgE of patients allergic to
CC       pine nut (PubMed:27211622). {ECO:0000269|PubMed:27211622}.
CC   -!- SIMILARITY: Belongs to the 2S seed storage albumins family.
CC       {ECO:0000305}.
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DR   EMBL; LN876267; CTQ87571.1; -; mRNA.
DR   AlphaFoldDB; A0A0K3AVY3; -.
DR   Allergome; 10430; Pin p 1.
DR   Allergome; 11854; Pin p 1.0101.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   CDD; cd00261; AAI_SS; 1.
DR   Gene3D; 1.10.110.10; -; 1.
DR   InterPro; IPR044723; AAI_SS_dom.
DR   InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR   InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR   Pfam; PF00234; Tryp_alpha_amyl; 1.
DR   SMART; SM00499; AAI; 1.
DR   SUPFAM; SSF47699; SSF47699; 1.
PE   1: Evidence at protein level;
KW   Allergen; Glycoprotein; Seed storage protein; Signal; Storage protein.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..164
FT                   /note="2S albumin seed storage protein PINP1"
FT                   /id="PRO_5005494271"
FT   REGION          92..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..137
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        138
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:27211622"
SQ   SEQUENCE   164 AA;  18973 MW;  D26EBFBC45F0D025 CRC64;
     MGVFSSPMST LRWVTLFAAL LSLLEWGTAH EDIVMDGDQV VQQQGRSCDP QRLSACRDYL
     QRRREQPSER CCEELQRMSP HCRCRAIERA LDQSQSYDSS TDSDSQDGAP LNQRRRRRGE
     GRGREEEEAV ERAEELPNRC NLRESPRRCD IRRHSRYSII GGSD