ID   PIN_BPT4                Reviewed;         161 AA.
AC   P07068;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   02-JUN-2021, entry version 70.
DE   RecName: Full=Host protease inhibitor;
DE            Short=Protein pin;
GN   Name=pin; Synonyms=pinA;
OS   Enterobacteria phage T4 (Bacteriophage T4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus.
OX   NCBI_TaxID=10665;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C;
RX   PubMed=3575111; DOI=10.1093/nar/15.8.3632;
RA   Tomaschewski J., Rueger W.;
RT   "Nucleotide sequence and primary structures of gene products coded for by
RT   the T4 genome between map positions 48.266 kb and 39.166 kb.";
RL   Nucleic Acids Res. 15:3632-3633(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12626685; DOI=10.1128/mmbr.67.1.86-156.2003;
RA   Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.;
RT   "Bacteriophage T4 genome.";
RL   Microbiol. Mol. Biol. Rev. 67:86-156(2003).
RN   [3]
RP   FUNCTION.
RX   PubMed=2838455; DOI=10.1128/jb.170.7.3016-3024.1988;
RA   Skorupski K., Tomaschewski J., Rueger W., Simon L.D.;
RT   "A bacteriophage T4 gene which functions to inhibit Escherichia coli Lon
RT   protease.";
RL   J. Bacteriol. 170:3016-3024(1988).
CC   -!- FUNCTION: Plays a role in the inhibition of bacterial toxin-antitoxin
CC       system by blocking the action of host Lon protease.
CC       {ECO:0000269|PubMed:2838455}.
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DR   EMBL; Y00122; CAA68306.1; -; Genomic_DNA.
DR   EMBL; AF158101; AAD42641.1; -; Genomic_DNA.
DR   PIR; I30292; Z3BPT9.
DR   RefSeq; NP_049694.1; NC_000866.4.
DR   MEROPS; I24.001; -.
DR   GeneID; 1258773; -.
DR   KEGG; vg:1258773; -.
DR   Proteomes; UP000009087; Genome.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IDA:CACAO.
DR   GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019506; Pept-inhibitor_PinA.
DR   Pfam; PF10465; Inhibitor_I24; 1.
PE   4: Predicted;
KW   Protease inhibitor; Reference proteome.
FT   CHAIN           1..161
FT                   /note="Host protease inhibitor"
FT                   /id="PRO_0000164966"
SQ   SEQUENCE   161 AA;  18816 MW;  355D8E88B7DBD1A0 CRC64;
     MITVDKWFRI NRADTGLCNY WPELSAGTVF KVRELVKECE DDIEPDTGII EIELSDGKII
     NIYDKPITYW CLWNTESVEN GEIEEVVERT NQVVQKPKAD FQGERISYAL AKLAAQENND
     GYEGNLMQAA AEYIEWLETQ ISFSDRMIQQ YKRLHQMFYN T