PIP12_MUSAM
ID PIP12_MUSAM Reviewed; 287 AA.
AC A0A804KTT0;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 1.
DT 03-AUG-2022, entry version 4.
DE RecName: Full=Aquaporin PIP1-2 {ECO:0000303|PubMed:26307965};
DE AltName: Full=Plasma membrane intrinsic protein 1-2 {ECO:0000303|PubMed:26307965};
DE Short=MusaPIP1-2 {ECO:0000303|PubMed:26307965};
DE Short=MusaPIP1;2 {ECO:0000303|PubMed:26307965};
GN Name=PIP1-2 {ECO:0000303|PubMed:26307965};
GN OrderedLocusNames=Ma10_g07860 {ECO:0000312|EMBL:CAG1852872.1};
GN ORFNames=GSMUA_310980.1 {ECO:0000312|EMBL:CAG1852872.1};
OS Musa acuminata subsp. malaccensis (Wild banana) (Musa malaccensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Zingiberales; Musaceae; Musa.
OX NCBI_TaxID=214687;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Doubled-haploid Pahang;
RG Genoscope - CEA;
RA William W.;
RL Submitted (MAR-2021) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=26307965; DOI=10.3390/ijms160819728;
RA Hu W., Hou X., Huang C., Yan Y., Tie W., Ding Z., Wei Y., Liu J., Miao H.,
RA Lu Z., Li M., Xu B., Jin Z.;
RT "Genome-wide identification and expression analyses of aquaporin gene
RT family during development and abiotic stress in banana.";
RL Int. J. Mol. Sci. 16:19728-19751(2015).
CC -!- FUNCTION: Water channel required to facilitate the transport of water
CC across cell membrane; mercury-insensitive (By similarity). Contributes
CC to the tolerance to multiple abiotic stresses including salt (NaCl),
CC cold and water deprivation, by modulating cytosolic K(+)/Na(+) ratio,
CC maintaining osmotic balance, and reducing membrane injury (e.g.
CC oxidative injury) (By similarity). {ECO:0000250|UniProtKB:P0DO53,
CC ECO:0000250|UniProtKB:P30302}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P0DO53};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Barely detectable in roots, leaves and fruits.
CC {ECO:0000269|PubMed:26307965}.
CC -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC membrane-spanning domains and a pore-forming loop with the signature
CC motif Asn-Pro-Ala (NPA). {ECO:0000305}.
CC -!- BIOTECHNOLOGY: Can be used to improve resistance to abiotic stresses
CC such as cold, drought and salt. {ECO:0000250|UniProtKB:P0DO53}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC
CC 1.A.8.11) subfamily. {ECO:0000305}.
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DR EMBL; HG996476; CAG1852872.1; -; Genomic_DNA.
DR RefSeq; XP_009420459.1; XM_009422184.2.
DR EnsemblPlants; Ma10_t07860.1; Ma10_p07860.1; Ma10_g07860.
DR GeneID; 104000197; -.
DR Gramene; Ma10_t07860.1; Ma10_p07860.1; Ma10_g07860.
DR KEGG; mus:104000197; -.
DR Proteomes; UP000012960; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015267; F:channel activity; IEA:InterPro.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; -; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR034294; Aquaporin_transptr.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR PANTHER; PTHR45687; PTHR45687; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; SSF81338; 1.
DR TIGRFAMs; TIGR00861; MIP; 1.
DR PROSITE; PS00221; MIP; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Stress response;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..287
FT /note="Aquaporin PIP1-2"
FT /id="PRO_0000455808"
FT TOPO_DOM 1..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 56..76
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..89
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 90..110
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 134..154
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..175
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 176..196
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 210..230
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..257
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 258..278
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT MOTIF 115..117
FT /note="NPA 1"
FT /evidence="ECO:0000255"
FT MOTIF 236..238
FT /note="NPA 2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 287 AA; 30629 MW; E8B42435B451C1AE CRC64;
MEGKEEDVRL GANKFTERQP IGTAAQSQDK DYKEPPPAPL FEPGELSSWS FYRAGIAEFV
ATFLFLYITI LTVMGVVKSS TKCSTVGIQG IAWAFGGMIF ALVYCTAGIS GGHINPAVTF
GLFLARKLSL TRALFYMVMQ CLGAICGAGV VKGFQKGLYE NNGGGANVVA PGYTKGDGLG
AEIVGTFILV YTVFSATDAK RSARDSHVPI LAPLPIGFAV FLVHLATIPI TGTGINPARS
LGAAIIYNKG HAWDDHWIFW VGPFIGAALA ALYHQVVIRA IPFKSRS
