ID   PIP15_MAIZE             Reviewed;         288 AA.
AC   Q9AR14;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Aquaporin PIP1-5;
DE   AltName: Full=Plasma membrane intrinsic protein 1-5;
DE   AltName: Full=ZmPIP1-5;
DE   AltName: Full=ZmPIP1-5b;
DE   AltName: Full=ZmPIP1;5;
GN   Name=PIP1-5; Synonyms=PIP1E, PIP4;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. B73;
RX   PubMed=11244102; DOI=10.1104/pp.125.3.1206;
RA   Chaumont F., Barrieu F., Wojcik E., Chrispeels M.J., Jung R.;
RT   "Aquaporins constitute a large and highly divergent protein family in
RT   maize.";
RL   Plant Physiol. 125:1206-1215(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC   TISSUE=Root;
RA   Gaspar M., Sissoeff I., Bousser A., Roche O., Hoarau J., Mahe A.;
RT   "Cloning and characterization of ZmPIP1-5b, an aquaporin transporting water
RT   and urea.";
RL   Plant Sci. 165:21-31(2003).
CC   -!- FUNCTION: Water channel required to facilitate the transport of water
CC       across cell membrane. {ECO:0000269|Ref.2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in roots and at lower levels in
CC       anthers and silks. {ECO:0000269|Ref.2}.
CC   -!- INDUCTION: By nitrate in roots. Expressed in roots with a circadian
CC       rhythm showing an increase at the end of the night period, a peak
CC       during the first part of the light period and then a decrease.
CC       {ECO:0000269|Ref.2}.
CC   -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC       membrane-spanning domains and a pore-forming loop with the signature
CC       motif Asn-Pro-Ala (NPA).
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC
CC       1.A.8.11) subfamily. {ECO:0000305}.
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DR   EMBL; AF326489; AAK26756.1; -; mRNA.
DR   EMBL; AJ271796; CAC33802.1; -; mRNA.
DR   RefSeq; NP_001105131.1; NM_001111661.1.
DR   AlphaFoldDB; Q9AR14; -.
DR   SMR; Q9AR14; -.
DR   STRING; 4577.GRMZM2G081843_P01; -.
DR   PaxDb; Q9AR14; -.
DR   PRIDE; Q9AR14; -.
DR   GeneID; 542014; -.
DR   KEGG; zma:542014; -.
DR   MaizeGDB; 403368; -.
DR   eggNOG; KOG0223; Eukaryota.
DR   HOGENOM; CLU_020019_3_0_1; -.
DR   OMA; DIWTSHW; -.
DR   OrthoDB; 1152704at2759; -.
DR   Proteomes; UP000007305; Chromosome 4.
DR   ExpressionAtlas; Q9AR14; baseline and differential.
DR   Genevisible; Q9AR14; ZM.
DR   GO; GO:0016021; C:integral component of membrane; TAS:AgBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015250; F:water channel activity; IBA:GO_Central.
DR   CDD; cd00333; MIP; 1.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR022357; MIP_CS.
DR   PANTHER; PTHR45687; PTHR45687; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; SSF81338; 1.
DR   TIGRFAMs; TIGR00861; MIP; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..288
FT                   /note="Aquaporin PIP1-5"
FT                   /id="PRO_0000286016"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..114
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           116..118
FT                   /note="NPA 1"
FT                   /evidence="ECO:0000250"
FT   MOTIF           237..239
FT                   /note="NPA 2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   288 AA;  30725 MW;  5DEBF23DEA26289B CRC64;
     MEGKEEDVRL GANRYSERQP IGTAAQGTEE KDYKEPPPAP LFEAEELTSW SFYRAGIAEF
     VATFLFLYIS ILTVMGVSKS SSKCATVGIQ GIAWSFGGMI FALVYCTAGI SGGHINPAVT
     FGLFLARKLS LTRALFYMVM QCLGAICGAG VVKGFQEGLY MGAGGGANAV NPGYTKGDGL
     GAEIVGTFVL VYTVFSATDA KRSARDSHVP ILAPLPIGFA VFLVHLATIP ITGTGINPAR
     SLGAAIVYNR SHAWNDHWIF WVGPFIGAAL AAIYHVVIIR ALPFKSRD