PIP1_ARATH
ID PIP1_ARATH Reviewed; 72 AA.
AC Q1PE40; A0MFA5; O49455;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=PAMP-induced secreted peptide 1 {ECO:0000303|PubMed:25188390};
DE Flags: Precursor;
GN Name=PIP1 {ECO:0000303|PubMed:25188390};
GN OrderedLocusNames=At4g28460 {ECO:0000312|Araport:AT4G28460};
GN ORFNames=F20O9.140 {ECO:0000312|EMBL:CAA16885.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP FUNCTION, INTERACTION WITH RLK7, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP INDUCTION, AND HYDROXYLATION AT PRO-65 AND PRO-67.
RX PubMed=25188390; DOI=10.1371/journal.ppat.1004331;
RA Hou S., Wang X., Chen D., Yang X., Wang M., Turra D., Di Pietro A.,
RA Zhang W.;
RT "The secreted peptide PIP1 amplifies immunity through receptor-like kinase
RT 7.";
RL PLoS Pathog. 10:E1004331-E1004331(2014).
CC -!- FUNCTION: Endogenous secreted peptide that acts as elicitor of immune
CC response and positive regulator of defense response. Amplifies the
CC immune response triggered by flg22, the active epitope of bacterial
CC flagellin. Acts as negative regulator of root growth.
CC {ECO:0000269|PubMed:25188390}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, apoplast
CC {ECO:0000269|PubMed:25188390}.
CC -!- TISSUE SPECIFICITY: Expressed in guard cells, hydathodes, leaf
CC trichomes, and vascular tissues of leaves and roots.
CC {ECO:0000269|PubMed:25188390}.
CC -!- INDUCTION: Induced by infection with the bacterial pathogen Pseudomonas
CC syringae pv tomato strain DC3000 and the fungal pathogen Fusarium
CC oxysporum conglutinans strain 699. Induced by the flagellin flg22,
CC chitin elicitor and salicylate.
CC -!- PTM: Contains 4-hydroxyproline; hydroxylated on Pro-65 and Pro-67.
CC {ECO:0000305|PubMed:25188390}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28261.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA16885.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB79648.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL021749; CAA16885.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL161572; CAB79648.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002687; AEE85489.1; -; Genomic_DNA.
DR EMBL; DQ446878; ABE65536.1; -; Genomic_DNA.
DR EMBL; DQ653231; ABK28261.1; ALT_SEQ; Genomic_DNA.
DR PIR; T04616; T04616.
DR RefSeq; NP_194575.2; NM_118988.3.
DR AlphaFoldDB; Q1PE40; -.
DR STRING; 3702.AT4G28460.1; -.
DR PaxDb; Q1PE40; -.
DR PRIDE; Q1PE40; -.
DR EnsemblPlants; AT4G28460.1; AT4G28460.1; AT4G28460.
DR GeneID; 828963; -.
DR Gramene; AT4G28460.1; AT4G28460.1; AT4G28460.
DR KEGG; ath:AT4G28460; -.
DR Araport; AT4G28460; -.
DR TAIR; locus:2121343; AT4G28460.
DR HOGENOM; CLU_2708279_0_0_1; -.
DR InParanoid; Q1PE40; -.
DR OrthoDB; 1604456at2759; -.
DR PhylomeDB; Q1PE40; -.
DR PRO; PR:Q1PE40; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q1PE40; baseline and differential.
DR GO; GO:0048046; C:apoplast; IDA:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; IDA:TAIR.
DR GO; GO:0006955; P:immune response; IEP:TAIR.
DR GO; GO:0045087; P:innate immune response; IMP:UniProtKB.
DR GO; GO:2000280; P:regulation of root development; IMP:UniProtKB.
DR InterPro; IPR040273; PIP1.
DR PANTHER; PTHR37245; PTHR37245; 1.
PE 1: Evidence at protein level;
KW Apoplast; Hydroxylation; Plant defense; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..72
FT /note="PAMP-induced secreted peptide 1"
FT /evidence="ECO:0000255"
FT /id="PRO_5011945934"
FT MOD_RES 65
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000305|PubMed:25188390"
FT MOD_RES 67
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000305|PubMed:25188390"
SQ SEQUENCE 72 AA; 7831 MW; A6A9490E420B9D57 CRC64;
MRRVSWSTVL IVVVMVSLFF VEHVVVPAAA GRVLTEKSGD GSATMTVEKM KSTVDSWFQR
LASGPSPRGR GH
