ID   PIPB_SALTY              Reviewed;         291 AA.
AC   Q8ZQ59;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Secreted effector protein PipB;
GN   Name=pipB; OrderedLocusNames=STM1088;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, SECRETION VIA TYPE III SECRETION SYSTEM,
RP   AND INDUCTION.
RC   STRAIN=SL1344;
RX   PubMed=11918798; DOI=10.1046/j.1365-2958.2002.02820.x;
RA   Knodler L.A., Celli J., Hardt W.D., Vallance B.A., Yip C., Finlay B.B.;
RT   "Salmonella effectors within a single pathogenicity island are
RT   differentially expressed and translocated by separate type III secretion
RT   systems.";
RL   Mol. Microbiol. 43:1089-1103(2002).
RN   [3]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=SL1344;
RX   PubMed=12864852; DOI=10.1046/j.1365-2958.2003.03598.x;
RA   Knodler L.A., Vallance B.A., Hensel M., Jaeckel D., Finlay B.B.,
RA   Steele-Mortimer O.;
RT   "Salmonella type III effectors PipB and PipB2 are targeted to detergent-
RT   resistant microdomains on internal host cell membranes.";
RL   Mol. Microbiol. 49:685-704(2003).
CC   -!- FUNCTION: Effector proteins function to alter host cell physiology and
CC       promote bacterial survival in host tissues. Does not appear to be
CC       required for the formation or the maintenance of either Salmonella-
CC       containing vacuole (SCV) or the Salmonella-induced filaments (Sifs).
CC       Not required for intracellular replication in phagocytic cells.
CC       {ECO:0000269|PubMed:11918798}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11918798}. Host
CC       membrane {ECO:0000269|PubMed:12864852}. Note=Secreted via type III
CC       secretion system 2 (SPI-2 TTSS), and delivered into the host cell.
CC       Concentrates in detergent-resistant microdomains (DRMs) that are
CC       present on the membranes of Salmonella-containing vacuole (SCV) and
CC       Salmonella-induced filaments (Sifs). {ECO:0000269|PubMed:11918798}.
CC   -!- INDUCTION: Expression is regulated by the two-component regulatory
CC       system SsrA/SsrB. Induced after bacterial entry into host cell.
CC       {ECO:0000269|PubMed:11918798}.
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DR   EMBL; AE006468; AAL20020.1; -; Genomic_DNA.
DR   RefSeq; NP_460061.1; NC_003197.2.
DR   RefSeq; WP_001123045.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZQ59; -.
DR   SMR; Q8ZQ59; -.
DR   STRING; 99287.STM1088; -.
DR   PaxDb; Q8ZQ59; -.
DR   EnsemblBacteria; AAL20020; AAL20020; STM1088.
DR   GeneID; 1252606; -.
DR   KEGG; stm:STM1088; -.
DR   PATRIC; fig|99287.12.peg.1152; -.
DR   HOGENOM; CLU_067808_0_0_6; -.
DR   OMA; CFREVIG; -.
DR   PhylomeDB; Q8ZQ59; -.
DR   BioCyc; SENT99287:STM1088-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IDA:UniProtKB.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030254; P:protein secretion by the type III secretion system; IDA:UniProtKB.
DR   InterPro; IPR001646; 5peptide_repeat.
DR   Pfam; PF00805; Pentapeptide; 2.
PE   2: Evidence at transcript level;
KW   Host membrane; Membrane; Reference proteome; Repeat; Secreted; Virulence.
FT   CHAIN           1..291
FT                   /note="Secreted effector protein PipB"
FT                   /id="PRO_0000391634"
FT   DOMAIN          154..193
FT                   /note="Pentapeptide repeat 1"
FT   DOMAIN          199..238
FT                   /note="Pentapeptide repeat 2"
SQ   SEQUENCE   291 AA;  31805 MW;  F1D082E767FE5AD8 CRC64;
     MPITNASPEN ILRYLHAAGT GTKEAMKSAT SPRGILEWFV NFFTCGGVRR SNERWFREVI
     GKLTTSLLYV NKNAFFDGNK IFLEDVNGCT ICLSCGAASE NTDPMVIIEV NKNGKTVTDK
     VDSERFWNVC RMLKLMSKHN IQQPDSLITE DGFLNLRGVN LAHKDFQGED LSKIDASNAD
     FRETTLSNVN LVGANLCCAN LHAVNLMGSN MTKANLTHAD LTCANMSGVN LTAAILFGSD
     LTDTKLNGAK LDKIALTLAK ALTGADLTGS QHTPTPLPDY NDRTLFPHPI F