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PIPE_DROME
ID   PIPE_DROME              Reviewed;         514 AA.
AC   Q86BJ3; B9EQT7; E1JI38; E4NKL9; E8NH03; F2FB47; O96662; Q7KNQ1; Q86BJ2;
AC   Q86BJ4; Q86BJ5; Q86BJ6; Q86BJ7; Q86BJ8; Q86BJ9; Q86BK0; Q8IQU0; Q968U2;
AC   Q9VVY5;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Heparan sulfate 2-O-sulfotransferase pipe;
DE            EC=2.8.2.-;
GN   Name=pip; ORFNames=CG9614;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 8), NUCLEOTIDE SEQUENCE [MRNA]
RP   OF 1-379 (ISOFORM 4), FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=9827800; DOI=10.1016/s0092-8674(00)81615-3;
RA   Sen J., Goltz J.S., Stevens L., Stein D.;
RT   "Spatially restricted expression of pipe in the Drosophila egg chamber
RT   defines embryonic dorsal-ventral polarity.";
RL   Cell 95:471-481(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORMS 1;
RP   3; 4; 5; 7; 8; 9; 10 AND 11), AND TISSUE SPECIFICITY.
RX   PubMed=11169845;
RX   DOI=10.1002/1097-0177(2000)9999:9999<::aid-dvdy1094>3.0.co;2-a;
RA   Sergeev P., Streit A., Heller A., Steinmann-Zwicky M.;
RT   "The Drosophila dorsoventral determinant PIPE contains ten copies of a
RT   variable domain homologous to mammalian heparan sulfate 2-
RT   sulfotransferase.";
RL   Dev. Dyn. 220:122-132(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [4]
RP   GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5; 7; 10 AND 13).
RC   STRAIN=Berkeley; TISSUE=Embryo, Larva, and Pupae;
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Booth B., Carlson J.W.,
RA   Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
RA   George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G.,
RA   Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S.,
RA   Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M.,
RA   Celniker S.E.;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   FUNCTION.
RX   PubMed=9568717; DOI=10.1016/s0092-8674(00)81576-7;
RA   Nilson L.A., Schuepbach T.;
RT   "Localized requirements for windbeutel and pipe reveal a dorsoventral
RT   prepattern within the follicular epithelium of the Drosophila ovary.";
RL   Cell 93:253-262(1998).
RN   [7]
RP   SUBCELLULAR LOCATION.
RX   PubMed=11076773; DOI=10.1242/dev.127.24.5541;
RA   Sen J., Goltz J.S., Konsolaki M., Schuepbach T., Stein D.;
RT   "Windbeutel is required for function and correct subcellular localization
RT   of the Drosophila patterning protein Pipe.";
RL   Development 127:5541-5550(2000).
RN   [8]
RP   INDUCTION.
RX   PubMed=12050143; DOI=10.1242/dev.129.12.2965;
RA   Peri F., Technau M., Roth S.;
RT   "Mechanisms of Gurken-dependent pipe regulation and the robustness of
RT   dorsoventral patterning in Drosophila.";
RL   Development 129:2965-2975(2002).
RN   [9]
RP   INTERACTION WITH WBL.
RX   PubMed=15252019; DOI=10.1074/jbc.m406839200;
RA   Barnewitz K., Guo C., Sevvana M., Ma Q., Sheldrick G.M., Soeling H.-D.,
RA   Ferrari D.M.;
RT   "Mapping of a substrate binding site in the protein disulfide isomerase-
RT   related chaperone wind based on protein function and crystal structure.";
RL   J. Biol. Chem. 279:39829-39837(2004).
CC   -!- FUNCTION: Sulfotransferase involved in dorsoventral axis patterning in
CC       early embryos. Required for the specific ventral activation of a series
CC       of proteases acting in the perivitelline space between the embryonic
CC       membrane and the eggshell. Probably acts by mediating the sulfation of
CC       some glycoprotein or glycosaminoglycan stably deposited in the egg,
CC       whose ventrally localized modification leads to spatially restricted
CC       activation of the protease cascade. {ECO:0000269|PubMed:9568717,
CC       ECO:0000269|PubMed:9827800}.
CC   -!- SUBUNIT: Interacts directly with windbeutel (wbl).
CC       {ECO:0000269|PubMed:15252019}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000269|PubMed:11076773}; Single-pass type II membrane protein
CC       {ECO:0000269|PubMed:11076773}. Note=Wbl is required for its processing
CC       into the Golgi.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=12;
CC       Name=1; Synonyms=Box 2, L, st2;
CC         IsoId=Q86BJ3-1; Sequence=Displayed;
CC       Name=2; Synonyms=Box 3, C, st3;
CC         IsoId=Q86BJ3-2; Sequence=VSP_014075, VSP_014076;
CC       Name=3; Synonyms=Box 6, G, st6;
CC         IsoId=Q86BJ3-3; Sequence=VSP_014069, VSP_014070;
CC       Name=4; Synonyms=A, Box 10, Pipe-ST2, st10;
CC         IsoId=Q86BJ3-4; Sequence=VSP_014067, VSP_014068;
CC       Name=5; Synonyms=Box 7, H, st7;
CC         IsoId=Q86BJ3-5; Sequence=VSP_014073, VSP_014074;
CC       Name=7; Synonyms=Box 1, K, st1;
CC         IsoId=Q86BJ3-7; Sequence=VSP_014071, VSP_014072;
CC       Name=8; Synonyms=Box 9, J, Pipe-ST1, st9;
CC         IsoId=Q86BJ3-8; Sequence=VSP_014077, VSP_014078;
CC       Name=9; Synonyms=Box 8, I, st8;
CC         IsoId=Q86BJ3-9; Sequence=VSP_014081, VSP_014082;
CC       Name=10; Synonyms=Box 4, F, st4;
CC         IsoId=Q86BJ3-10; Sequence=VSP_014079, VSP_014080;
CC       Name=11; Synonyms=Box 5, D, st5;
CC         IsoId=Q86BJ3-11; Sequence=VSP_014065, VSP_014066;
CC       Name=12; Synonyms=N;
CC         IsoId=Q86BJ3-12; Sequence=VSP_054035;
CC       Name=13; Synonyms=M;
CC         IsoId=Q86BJ3-13; Sequence=VSP_054034, VSP_054036;
CC   -!- TISSUE SPECIFICITY: Isoform 4 is ovary-specific. Isoform 4 and isoform
CC       5 are specifically expressed in the ventral follicle cells of the egg
CC       chamber. {ECO:0000269|PubMed:11169845, ECO:0000269|PubMed:9827800}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from stage 12 embryos and continues
CC       throughout development. Isoform 4 is expressed from stage 14 in the
CC       somatic component of the embryonic ovary.
CC   -!- INDUCTION: Down-regulated by gurken (grk) and EGF receptor signaling,
CC       preventing its expression in dorsal follicle cells.
CC       {ECO:0000269|PubMed:12050143, ECO:0000269|PubMed:9827800}.
CC   -!- SIMILARITY: Belongs to the sulfotransferase 3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD04925.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=ACM16727.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=ADZ49072.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC       Sequence=ADZ49072.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC       Sequence=AED98571.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR   EMBL; AF102135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF102136; AAD04925.1; ALT_INIT; mRNA.
DR   EMBL; AF263993; AAK56855.1; -; mRNA.
DR   EMBL; AE014296; AAF49170.2; -; Genomic_DNA.
DR   EMBL; AE014296; AAN11662.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAO41225.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAO41226.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAO41227.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAO41228.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAO41229.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAO41230.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAO41231.2; -; Genomic_DNA.
DR   EMBL; AE014296; AAO41232.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAO41233.1; -; Genomic_DNA.
DR   EMBL; AE014296; ACZ94738.1; -; Genomic_DNA.
DR   EMBL; BT010278; AAQ23596.1; -; mRNA.
DR   EMBL; BT058012; ACM16727.1; ALT_INIT; mRNA.
DR   EMBL; BT125816; ADR71725.1; -; mRNA.
DR   EMBL; BT125857; ADU79245.1; -; mRNA.
DR   EMBL; BT126134; ADZ49072.1; ALT_SEQ; mRNA.
DR   EMBL; BT126392; AED98571.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001163467.1; NM_001169996.2.
DR   RefSeq; NP_524158.2; NM_079434.3. [Q86BJ3-4]
DR   RefSeq; NP_730402.1; NM_168793.2. [Q86BJ3-2]
DR   RefSeq; NP_788529.1; NM_176351.4. [Q86BJ3-8]
DR   RefSeq; NP_788530.1; NM_176352.2. [Q86BJ3-9]
DR   RefSeq; NP_788531.1; NM_176353.2. [Q86BJ3-5]
DR   RefSeq; NP_788532.1; NM_176354.2. [Q86BJ3-3]
DR   RefSeq; NP_788533.1; NM_176355.2. [Q86BJ3-11]
DR   RefSeq; NP_788534.1; NM_176356.2. [Q86BJ3-10]
DR   RefSeq; NP_788535.2; NM_176357.2. [Q86BJ3-12]
DR   RefSeq; NP_788536.1; NM_176358.2. [Q86BJ3-1]
DR   RefSeq; NP_788537.1; NM_176359.2. [Q86BJ3-7]
DR   AlphaFoldDB; Q86BJ3; -.
DR   SMR; Q86BJ3; -.
DR   BioGRID; 65379; 21.
DR   IntAct; Q86BJ3; 8.
DR   STRING; 7227.FBpp0074780; -.
DR   GlyGen; Q86BJ3; 5 sites.
DR   PaxDb; Q86BJ3; -.
DR   DNASU; 40104; -.
DR   EnsemblMetazoa; FBtr0075003; FBpp0074770; FBgn0003089. [Q86BJ3-4]
DR   EnsemblMetazoa; FBtr0075004; FBpp0074771; FBgn0003089. [Q86BJ3-2]
DR   EnsemblMetazoa; FBtr0075005; FBpp0074772; FBgn0003089. [Q86BJ3-11]
DR   EnsemblMetazoa; FBtr0075007; FBpp0074774; FBgn0003089. [Q86BJ3-10]
DR   EnsemblMetazoa; FBtr0075008; FBpp0074775; FBgn0003089. [Q86BJ3-3]
DR   EnsemblMetazoa; FBtr0075009; FBpp0074776; FBgn0003089. [Q86BJ3-5]
DR   EnsemblMetazoa; FBtr0075010; FBpp0074777; FBgn0003089. [Q86BJ3-9]
DR   EnsemblMetazoa; FBtr0075011; FBpp0074778; FBgn0003089. [Q86BJ3-8]
DR   EnsemblMetazoa; FBtr0075012; FBpp0074779; FBgn0003089. [Q86BJ3-7]
DR   EnsemblMetazoa; FBtr0075013; FBpp0074780; FBgn0003089. [Q86BJ3-1]
DR   EnsemblMetazoa; FBtr0333897; FBpp0306029; FBgn0003089. [Q86BJ3-12]
DR   GeneID; 40104; -.
DR   KEGG; dme:Dmel_CG9614; -.
DR   UCSC; CG9614-RA; d. melanogaster. [Q86BJ3-1]
DR   CTD; 5304; -.
DR   FlyBase; FBgn0003089; pip.
DR   VEuPathDB; VectorBase:FBgn0003089; -.
DR   eggNOG; KOG3922; Eukaryota.
DR   GeneTree; ENSGT00530000063408; -.
DR   InParanoid; Q86BJ3; -.
DR   OMA; YHYVREQ; -.
DR   PhylomeDB; Q86BJ3; -.
DR   Reactome; R-DME-2022923; Dermatan sulfate biosynthesis.
DR   SignaLink; Q86BJ3; -.
DR   BioGRID-ORCS; 40104; 0 hits in 1 CRISPR screen.
DR   ChiTaRS; psq; fly.
DR   GenomeRNAi; 40104; -.
DR   PRO; PR:Q86BJ3; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0003089; Expressed in saliva-secreting gland and 25 other tissues.
DR   Genevisible; Q86BJ3; DM.
DR   GO; GO:0005694; C:chromosome; IDA:FlyBase.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:FlyBase.
DR   GO; GO:0030173; C:integral component of Golgi membrane; NAS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR   GO; GO:0008146; F:sulfotransferase activity; IMP:FlyBase.
DR   GO; GO:0009950; P:dorsal/ventral axis specification; IMP:FlyBase.
DR   GO; GO:0009880; P:embryonic pattern specification; IMP:FlyBase.
DR   GO; GO:1900005; P:positive regulation of serine-type endopeptidase activity; IMP:FlyBase.
DR   GO; GO:0045752; P:positive regulation of Toll signaling pathway; IMP:FlyBase.
DR   GO; GO:0040014; P:regulation of multicellular organism growth; IMP:FlyBase.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR007734; Heparan_SO4_2-O-STrfase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005331; Sulfotransferase.
DR   PANTHER; PTHR12129; PTHR12129; 1.
DR   Pfam; PF03567; Sulfotransfer_2; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Developmental protein; Glycoprotein; Golgi apparatus;
KW   Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..514
FT                   /note="Heparan sulfate 2-O-sulfotransferase pipe"
FT                   /id="PRO_0000207683"
FT   TOPO_DOM        1..30
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..50
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..514
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          112..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..126
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..145
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..172
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        207
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        287
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        416
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        451
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        467
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         106..418
FT                   /note="KVGYNVHDRRSSEEQLRTPTAHGHHHDHHSHHHHMHQQEKIDGHKHKASHDK
FT                   QLAVPDNKHKEDEVHYEDDEDEVEENDDDLANDVGTTDSEGFNFKADLLNNTKYAEVDF
FT                   VFFNRVPKVGSQSLMELMARLGKINGFTHARNKGSAHETIVMNKQRQNDLIADLLTRPK
FT                   PHIYSQHIAYINFTRFHLPKPIYINLIRDPIDRIISWHYYIRAPWYYRDMQAKLGENAI
FT                   PMPSEEFMNLDLDTCVRNHDPHCTFTQMQIKNPVGDHRRQTLFFCGMNQKLCMPFNSEA
FT                   AMQKAKRTVETEYAVVGTWEDTNIT -> ILQLSPDKLNNTPKAEIDVLFFNRVPKTGS
FT                   MQLIELMRQLGKVHDYDVEKDPQQGGVIPILETAEQSDLIDNIVNLDDGTVFASHVNFL
FT                   NFTKHEQPRPIYINMVRDPVERVISWYYYIRAPWVFVPGRRRNNREMPNPKWVNTEFDQ
FT                   CVTSGEKVCTYIENSLLEHVGDHRRQTLFFCGHNEFQCTPFNARLPLQLAKMNVEREYS
FT                   VVGTWEHTNETLAVLEAYVPRYFADASKMYYSGLHADKQNVNPMKPHISQDILDMVRRN
FT                   FTREIEFYQFCRQRLHKQYLALKLNDLKRVDKSLAMLSEAKEMAINN (in isoform
FT                   11)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_014065"
FT   VAR_SEQ         106..413
FT                   /note="KVGYNVHDRRSSEEQLRTPTAHGHHHDHHSHHHHMHQQEKIDGHKHKASHDK
FT                   QLAVPDNKHKEDEVHYEDDEDEVEENDDDLANDVGTTDSEGFNFKADLLNNTKYAEVDF
FT                   VFFNRVPKVGSQSLMELMARLGKINGFTHARNKGSAHETIVMNKQRQNDLIADLLTRPK
FT                   PHIYSQHIAYINFTRFHLPKPIYINLIRDPIDRIISWHYYIRAPWYYRDMQAKLGENAI
FT                   PMPSEEFMNLDLDTCVRNHDPHCTFTQMQIKNPVGDHRRQTLFFCGMNQKLCMPFNSEA
FT                   AMQKAKRTVETEYAVVGTWE -> MSSLNVRDLNNTRKAQMELVFFNRVPKVGSQTFME
FT                   LLRRLSERNNFQFHRDAVQKVETIRLAEDQQQEMAEVISELPEPSVFIKHVCFTNFTKF
FT                   NLPRPIYLNVVRDPVERVISWFYYVRAPWYFVERKAAFPDLPLPHPAWLKKDFETCVLN
FT                   GDQECTYTQGVTVEGIGDHRRQSLFFCGHDYECTPFNTVGALERAKFAVEQQYAVVGVL
FT                   EDLNTTLSVLEKYVPRFFEGVRDIYATSAEYLTKINKNNFKPPVSEHVKDIVRRNFTNE
FT                   IEFYQFCRQRLHKQYLAAHLPQRIITDSAHLPGLIGN (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:9827800"
FT                   /id="VSP_014067"
FT   VAR_SEQ         106..407
FT                   /note="KVGYNVHDRRSSEEQLRTPTAHGHHHDHHSHHHHMHQQEKIDGHKHKASHDK
FT                   QLAVPDNKHKEDEVHYEDDEDEVEENDDDLANDVGTTDSEGFNFKADLLNNTKYAEVDF
FT                   VFFNRVPKVGSQSLMELMARLGKINGFTHARNKGSAHETIVMNKQRQNDLIADLLTRPK
FT                   PHIYSQHIAYINFTRFHLPKPIYINLIRDPIDRIISWHYYIRAPWYYRDMQAKLGENAI
FT                   PMPSEEFMNLDLDTCVRNHDPHCTFTQMQIKNPVGDHRRQTLFFCGMNQKLCMPFNSEA
FT                   AMQKAKRTVETEYA -> LQQLSANRLNNTKNAEIEVLFFNRAAKVGSESMLELFMALE
FT                   KYNDDLTLERRGLHTRTVRQMDKKQRRESAEFVADLEEGTMYIEHINWLDFDEFDLPKP
FT                   IYINLVRDPVERVISWFFYARSSYKNAIEYRKRPNQKIKPESWYKKNFNDCVRSGDPEC
FT                   QYVPHTVKDSIANFKRQSLFYCGHHDDCLPFNSPTAVQMAKEHVERDYAVVGSWEDTNI
FT                   TLTVLENYIPRFFRGAKLMYEMHNSKITNRNKNKRKPFVEPEVKEMIRKNFTNEYEFYY
FT                   FCKQRLYKQYLALNLKELEVHGLLN (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_014069"
FT   VAR_SEQ         106..406
FT                   /note="KVGYNVHDRRSSEEQLRTPTAHGHHHDHHSHHHHMHQQEKIDGHKHKASHDK
FT                   QLAVPDNKHKEDEVHYEDDEDEVEENDDDLANDVGTTDSEGFNFKADLLNNTKYAEVDF
FT                   VFFNRVPKVGSQSLMELMARLGKINGFTHARNKGSAHETIVMNKQRQNDLIADLLTRPK
FT                   PHIYSQHIAYINFTRFHLPKPIYINLIRDPIDRIISWHYYIRAPWYYRDMQAKLGENAI
FT                   PMPSEEFMNLDLDTCVRNHDPHCTFTQMQIKNPVGDHRRQTLFFCGMNQKLCMPFNSEA
FT                   AMQKAKRTVETEY -> LKHLTTAQLNNTPRAQVDTLFFNRITKTGSEKMMELLKILGK
FT                   RHNFEARRDVEGFYEVVIMHDAFAKNFIRTEVLNCTKANSYTKHVAFLDFDLLDEPWPI
FT                   YINMVRDPIERLVSWFYYVRAPWHFAERKEMFGDAIVLPSIDWLRKDFNRCIEERDPEC
FT                   VYEQMEMGNLGDHRRQSLYLCGQNMAVCMPFNSHEAMQRAKKNVEEHYAVVGTWEDTNT
FT                   TLSVLEGYIPRFFSGAKDQYYALRKSLGNYNRNTYRPSLSDKARAVLSQNLTREIELYQ
FT                   FVRHRLYKQYIALKLEEDPKLWD (in isoform 7)"
FT                   /evidence="ECO:0000303|Ref.5"
FT                   /id="VSP_014071"
FT   VAR_SEQ         106..405
FT                   /note="KVGYNVHDRRSSEEQLRTPTAHGHHHDHHSHHHHMHQQEKIDGHKHKASHDK
FT                   QLAVPDNKHKEDEVHYEDDEDEVEENDDDLANDVGTTDSEGFNFKADLLNNTKYAEVDF
FT                   VFFNRVPKVGSQSLMELMARLGKINGFTHARNKGSAHETIVMNKQRQNDLIADLLTRPK
FT                   PHIYSQHIAYINFTRFHLPKPIYINLIRDPIDRIISWHYYIRAPWYYRDMQAKLGENAI
FT                   PMPSEEFMNLDLDTCVRNHDPHCTFTQMQIKNPVGDHRRQTLFFCGMNQKLCMPFNSEA
FT                   AMQKAKRTVETE -> LGSLTPSQLNNTAKAEMDRLFFTRCAKVGSESLTEFMEHLQKI
FT                   NNFQVDKYGIMKKSKRQLKPRAQAETAGYIYNLDEGSVYIEHVPWIDFNEYNLPKPIFI
FT                   NLVRDPVERMISWYYYVRNSYRNAIFYRNNPLAPLKPTAWFKKSYNDCVRSGDPECQYV
FT                   PLAVRDVEGNFKRQTLFFCGHDQDCLPFNSPLAVQIAKRRVETEYAVVGTWEETNITLT
FT                   VLEHYIPRYFARAKMIFNLYQKSLQNRNRNNRKPHVDADVRAMVRRNFTHEYDFYYFCK
FT                   QRLYMQYIALKRTELERLNFS (in isoform 5)"
FT                   /evidence="ECO:0000303|Ref.5"
FT                   /id="VSP_014073"
FT   VAR_SEQ         106..403
FT                   /note="KVGYNVHDRRSSEEQLRTPTAHGHHHDHHSHHHHMHQQEKIDGHKHKASHDK
FT                   QLAVPDNKHKEDEVHYEDDEDEVEENDDDLANDVGTTDSEGFNFKADLLNNTKYAEVDF
FT                   VFFNRVPKVGSQSLMELMARLGKINGFTHARNKGSAHETIVMNKQRQNDLIADLLTRPK
FT                   PHIYSQHIAYINFTRFHLPKPIYINLIRDPIDRIISWHYYIRAPWYYRDMQAKLGENAI
FT                   PMPSEEFMNLDLDTCVRNHDPHCTFTQMQIKNPVGDHRRQTLFFCGMNQKLCMPFNSEA
FT                   AMQKAKRTVE -> LWRLNPKFLNNTKFHFRDIIFYNRVPKTGSETLIELMIQLGKKND
FT                   FQNERSPFSKPTGMYWDVKRQKQEATRILELQEEPAFVYVEHMNYMNIRPFHLPQPIYI
FT                   NMIRDPVERVISWFYYKRTPWNSVKMYKVTGKFQNRTHYTKNFEECVLTHDPECRYDYG
FT                   LLFKDDSADHKRQSLFFCGHSPICEPFNTPAAIARAKQNVERDFSVVGSWEDTNVTLTV
FT                   LEHYIPRFFKGTMELYYEPNIGLAFKKANINPWKPKISERIKQIMRANFTQEYEFYYFC
FT                   KQRLYRQYFAINKQLHF (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11169845, ECO:0000303|Ref.5"
FT                   /id="VSP_014075"
FT   VAR_SEQ         106..401
FT                   /note="KVGYNVHDRRSSEEQLRTPTAHGHHHDHHSHHHHMHQQEKIDGHKHKASHDK
FT                   QLAVPDNKHKEDEVHYEDDEDEVEENDDDLANDVGTTDSEGFNFKADLLNNTKYAEVDF
FT                   VFFNRVPKVGSQSLMELMARLGKINGFTHARNKGSAHETIVMNKQRQNDLIADLLTRPK
FT                   PHIYSQHIAYINFTRFHLPKPIYINLIRDPIDRIISWHYYIRAPWYYRDMQAKLGENAI
FT                   PMPSEEFMNLDLDTCVRNHDPHCTFTQMQIKNPVGDHRRQTLFFCGMNQKLCMPFNSEA
FT                   AMQKAKRT -> LGRVNPMHLNNTRFAGSETVIFNRPTRVDSEQMVPLFRQLAAMNDIN
FT                   VVLNGPVRTMNRTRTEKEELTEAEWTIELEKGSIYMAHSNWLDFASFGFKKPIYISLVK
FT                   DPIDRMITDFYKRRSRVKRAIYRRMYPGRRERPDEWYQLSFNECVRNRSPECLFVQHAV
FT                   ADYIQDFKRQTLYFCGNAADCLPFNSHHATQVAKRRVEKEYSVVGTWEERNITLTVLEK
FT                   YVPRFFNHARFLYKLHSKSIRNRNRNNRKPHIDADVREMVRRNFTNEYEFYYFCKQRLY
FT                   KQYLALQLENNLH (in isoform 8)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_014077"
FT   VAR_SEQ         106..397
FT                   /note="KVGYNVHDRRSSEEQLRTPTAHGHHHDHHSHHHHMHQQEKIDGHKHKASHDK
FT                   QLAVPDNKHKEDEVHYEDDEDEVEENDDDLANDVGTTDSEGFNFKADLLNNTKYAEVDF
FT                   VFFNRVPKVGSQSLMELMARLGKINGFTHARNKGSAHETIVMNKQRQNDLIADLLTRPK
FT                   PHIYSQHIAYINFTRFHLPKPIYINLIRDPIDRIISWHYYIRAPWYYRDMQAKLGENAI
FT                   PMPSEEFMNLDLDTCVRNHDPHCTFTQMQIKNPVGDHRRQTLFFCGMNQKLCMPFNSEA
FT                   AMQK -> LENLEPAHLNNTPKAERDFIFYNRLEKTGSQSMTRLIKQLGDRLGFDTYRN
FT                   IVRPSRSITESEEDEKDLVEQLFELGEHAVYVEHANWVNFTQHDSPRPIYINMVRHPIQ
FT                   KVISAYYYQRHPLIFAQSLLRNPNKPMQTKKFFDTNFNDCVRKRVRPHCVFDAHNPFNG
FT                   DWRRFSLHLCGNSEICTHFNSETTTQIAKMNVEREYAVVGSWEDTNVTLAVLEAYIPRF
FT                   FTDATKVYYSNTENFTINNVSHDTHLDKDVEEYLKSSFSFEIELYLFIKQRLYKQYIAV
FT                   HKNEF (in isoform 10)"
FT                   /evidence="ECO:0000303|Ref.5"
FT                   /id="VSP_014079"
FT   VAR_SEQ         106..358
FT                   /note="KVGYNVHDRRSSEEQLRTPTAHGHHHDHHSHHHHMHQQEKIDGHKHKASHDK
FT                   QLAVPDNKHKEDEVHYEDDEDEVEENDDDLANDVGTTDSEGFNFKADLLNNTKYAEVDF
FT                   VFFNRVPKVGSQSLMELMARLGKINGFTHARNKGSAHETIVMNKQRQNDLIADLLTRPK
FT                   PHIYSQHIAYINFTRFHLPKPIYINLIRDPIDRIISWHYYIRAPWYYRDMQAKLGENAI
FT                   PMPSEEFMNLDLDTCVRNHDPHCT -> LASLSSKKLNNTRHSRLEVIFFNRGAKVGSE
FT                   ALMELTQTMAPYNNMTVVTKGPMDIKSRTRSPKEQMIQAIWVTELEPGTIYIEHCNWLD
FT                   FRRYQLPRPIYINLVRDPVERMISWYYYVRSGYRNAIHHRRFPNATIKSEKWFKKSYND
FT                   CVRSGDPECQYVPGSIKDPEGNYKRQTLFFCGHSRECLPFDSQRAIQLAKLNVERDYAV
FT                   VGTWEETNITLTVFEAYIPRFFKGVRNIFECRFHYERFKNVSGTT (in isoform
FT                   9)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_014081"
FT   VAR_SEQ         106..205
FT                   /note="KVGYNVHDRRSSEEQLRTPTAHGHHHDHHSHHHHMHQQEKIDGHKHKASHDK
FT                   QLAVPDNKHKEDEVHYEDDEDEVEENDDDLANDVGTTDSEGFNFKADL -> LGRVNPM
FT                   HLNNTRFAGSETVIFNRPTRVDSEQMVPLFRQLAAMNDINVVLNGPVRTMNRTRTEKEE
FT                   LTEAEWTIELEKGSIYMAHSNWLDFASFGFKKPIYISLVKDPIDRMITDFYKRRSRVKR
FT                   AIYRRMYPGRRERPDEWYQLSFNECVRNRSPECLFVQHAVADYIQDFKRQTLYFCGNAA
FT                   DCL (in isoform 13)"
FT                   /evidence="ECO:0000303|Ref.5"
FT                   /id="VSP_054034"
FT   VAR_SEQ         106
FT                   /note="Missing (in isoform 12)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_054035"
FT   VAR_SEQ         206..514
FT                   /note="Missing (in isoform 13)"
FT                   /evidence="ECO:0000303|Ref.5"
FT                   /id="VSP_054036"
FT   VAR_SEQ         359..514
FT                   /note="Missing (in isoform 9)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_014082"
FT   VAR_SEQ         398..514
FT                   /note="Missing (in isoform 10)"
FT                   /evidence="ECO:0000303|Ref.5"
FT                   /id="VSP_014080"
FT   VAR_SEQ         402..514
FT                   /note="Missing (in isoform 8)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_014078"
FT   VAR_SEQ         404..514
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11169845, ECO:0000303|Ref.5"
FT                   /id="VSP_014076"
FT   VAR_SEQ         406..514
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|Ref.5"
FT                   /id="VSP_014074"
FT   VAR_SEQ         407..514
FT                   /note="Missing (in isoform 7)"
FT                   /evidence="ECO:0000303|Ref.5"
FT                   /id="VSP_014072"
FT   VAR_SEQ         408..514
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_014070"
FT   VAR_SEQ         414..514
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:9827800"
FT                   /id="VSP_014068"
FT   VAR_SEQ         419..514
FT                   /note="Missing (in isoform 11)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_014066"
FT   CONFLICT        Q86BJ3-2:401
FT                   /note="L -> M (in Ref. 2; AAK56855)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   514 AA;  60260 MW;  84515CF230490F6B CRC64;
     MSLNAERSYK MKLRDVENAF KYRRIPYPKR SVELIALLAI SCTFFLFMHT NKLNSRLKEM
     EVKLQPSEFS ALGLTGNHIS GHDAGKHDDI NTLHGTYQYL KSTGQKVGYN VHDRRSSEEQ
     LRTPTAHGHH HDHHSHHHHM HQQEKIDGHK HKASHDKQLA VPDNKHKEDE VHYEDDEDEV
     EENDDDLAND VGTTDSEGFN FKADLLNNTK YAEVDFVFFN RVPKVGSQSL MELMARLGKI
     NGFTHARNKG SAHETIVMNK QRQNDLIADL LTRPKPHIYS QHIAYINFTR FHLPKPIYIN
     LIRDPIDRII SWHYYIRAPW YYRDMQAKLG ENAIPMPSEE FMNLDLDTCV RNHDPHCTFT
     QMQIKNPVGD HRRQTLFFCG MNQKLCMPFN SEAAMQKAKR TVETEYAVVG TWEDTNITLS
     VLEAYIPRYF RNAKVAYYLG KDRLSRVNRN NVTRIVSDET RLILRKNLTN EIEFYEFCKQ
     RLYLQYAALS HGKRFGEDDY LLVPEQQNEY NEDY
 
 
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