PIPSL_HUMAN
ID PIPSL_HUMAN Reviewed; 862 AA.
AC A2A3N6; Q6NUK8;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Putative PIP5K1A and PSMD4-like protein;
DE Short=PIP5K1A-PSMD4;
GN Name=PIPSL; Synonyms=PSMD4P2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND GENE EVOLUTION.
RX PubMed=17623810; DOI=10.1101/gr.6252107;
RA Babushok D.V., Ohshima K., Ostertag E.M., Chen X., Wang Y., Mandal P.K.,
RA Okada N., Abrams C.S., Kazazian H.H. Jr.;
RT "A novel testis ubiquitin-binding protein gene arose by exon shuffling in
RT hominoids.";
RL Genome Res. 17:1129-1138(2007).
CC -!- FUNCTION: Has negligible PIP5 kinase activity. Binds to ubiquitinated
CC proteins.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17623810}.
CC -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:17623810}.
CC -!- MISCELLANEOUS: PIPSL gene appeared in hominoids by L1-mediated
CC retrotransposition in a hominoid ancestor of a readthrough,
CC intergenically spliced transcript between the PIP5K1A and PSMD4 genes.
CC -!- CAUTION: Could be the product of a pseudogene. Although transcribed,
CC the gene is poorly translated probably due to a deletion in the
CC regulatory region. PubMed:17623810 could not detect the protein by
CC Western blot. {ECO:0000305}.
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DR EMBL; AL365510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A2A3N6; -.
DR SMR; A2A3N6; -.
DR IntAct; A2A3N6; 8.
DR MINT; A2A3N6; -.
DR GlyGen; A2A3N6; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; A2A3N6; -.
DR PhosphoSitePlus; A2A3N6; -.
DR BioMuta; HGNC:23733; -.
DR EPD; A2A3N6; -.
DR jPOST; A2A3N6; -.
DR MassIVE; A2A3N6; -.
DR MaxQB; A2A3N6; -.
DR PeptideAtlas; A2A3N6; -.
DR PRIDE; A2A3N6; -.
DR ProteomicsDB; 288; -.
DR GeneCards; PIPSL; -.
DR HGNC; HGNC:23733; PIPSL.
DR neXtProt; NX_A2A3N6; -.
DR InParanoid; A2A3N6; -.
DR PhylomeDB; A2A3N6; -.
DR PathwayCommons; A2A3N6; -.
DR SignaLink; A2A3N6; -.
DR ChiTaRS; PIPSL; human.
DR Pharos; A2A3N6; Tdark.
DR PRO; PR:A2A3N6; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A2A3N6; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IBA:GO_Central.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.30.800.10; -; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR023610; PInositol-4-P-5-kinase.
DR InterPro; IPR002498; PInositol-4-P-5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23086; PTHR23086; 1.
DR Pfam; PF01504; PIP5K; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SMART; SM00330; PIPKc; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS51455; PIPK; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 5: Uncertain;
KW Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..862
FT /note="Putative PIP5K1A and PSMD4-like protein"
FT /id="PRO_0000347057"
FT DOMAIN 28..396
FT /note="PIPK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00781"
FT DOMAIN 490..673
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DOMAIN 696..715
FT /note="UIM 1"
FT /evidence="ECO:0000305"
FT DOMAIN 766..783
FT /note="UIM 2"
FT /evidence="ECO:0000305"
FT REGION 404..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 862 AA; 95048 MW; 3F1F11EC0AB0D704 CRC64;
MASEVPYASG MPIKKIGHRS VDSSGGTTSS ALKGAIQLGI THTVGSLSTK PESDVLMQDF
HMVESIFFPS EGSNLTPAHH YNAFRFKTYA PVAFRYFWEL FGIRPDDYLY SLCSEPLIEL
CSSGASGSLF YVSSDDEFIV KTVRHKEAEF LQKLLPGYYI NLNQNPRTLL PKFYGLYCVQ
TGGKNIRIVV MNNLLPRSVK MHIKYDLKGS TYRRRASQKE REKPLPTFKD LDFLQDIPDG
LFLDADVHNA LCKTLQRDCL VLQSFKIMDY SLLMSIHNID HAQREPLSSE TQYSVDTRRP
APQKALYSTA MESIQGEARR GGTMETDDHM GGIPARNSKG ERLLLYIGII DILQSYRFVK
KLEHSWKALI HDGDTVSVHR PGFYAEWFQR FMCNTVFKKI PLKPSPSKKL RSGSSFSQRA
GSSGNSCITY QPLVSGEHKA QVTTKAEVEP GVHLGCPDVL PQTPPLEEIS EGSPTPDPSF
SPLVEETLQM LTTSVDNSEY MGNGDFLPTR LQAQQDAVNT VCHSKTRSNP ENNVGLITLD
NDCEVLTTLT PDTGRILSKL HTVQPKGKIT FCMGIHVAHL ALKHRQGNNH KIRIIAFVGN
PVEDNEKNLV KLAKCLKKEK VNVDIINFGE EEVNTEKLTA FVNTLNGKDG TGSHLVTVPP
GPSLADALIS FPILAGEGGA MMGLGASDFE FGVDPSADPE LALVLRVFME EQRQRQEEEA
RQAAAASAAE AGIATTGTED SDDALLKMTI SQQEFGHTGL PDLSSMTEEE KIVCAMQMSL
QGAEFGLAES ADIDASSAMD TSEPAKEEDD YDVMQDPEFL QSVLENLPGV DPNNEAIRNA
VGSLASQATK DSKKDKKEED KK
