A6_DROME
ID A6_DROME Reviewed; 409 AA.
AC O46341; Q9W564;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Protein a6;
GN Name=a6; ORFNames=CG3771;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=Oregon-RC; TISSUE=Larva;
RX PubMed=10546111;
RA Makunin I.V., Shestopal S.A., Beliaeva E.S., Ashburner M., Khimulev I.F.;
RT "Comparison of the molecular and genetic map of the 2B6-2B7-8 of Drosophila
RT melanogaster X-chromosome.";
RL Genetika 35:1071-1077(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R;
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; THR-133 AND SER-134, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- DEVELOPMENTAL STAGE: Expressed throughout embryogenesis.
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DR EMBL; Y16065; CAA76017.1; -; Genomic_DNA.
DR EMBL; Y16066; CAA76018.1; -; mRNA.
DR EMBL; AE014298; AAF45661.2; -; Genomic_DNA.
DR EMBL; AL031025; CAA19836.1; -; Genomic_DNA.
DR EMBL; AY069426; AAL39571.1; -; mRNA.
DR RefSeq; NP_001259141.1; NM_001272212.1.
DR RefSeq; NP_001259142.1; NM_001272213.1.
DR RefSeq; NP_477309.1; NM_057961.5.
DR AlphaFoldDB; O46341; -.
DR SMR; O46341; -.
DR BioGRID; 57676; 8.
DR DIP; DIP-19729N; -.
DR IntAct; O46341; 3.
DR STRING; 7227.FBpp0070269; -.
DR iPTMnet; O46341; -.
DR PaxDb; O46341; -.
DR DNASU; 31127; -.
DR EnsemblMetazoa; FBtr0070279; FBpp0070269; FBgn0023130.
DR EnsemblMetazoa; FBtr0330407; FBpp0303433; FBgn0023130.
DR EnsemblMetazoa; FBtr0333116; FBpp0305327; FBgn0023130.
DR GeneID; 31127; -.
DR KEGG; dme:Dmel_CG3771; -.
DR UCSC; CG3771-RA; d. melanogaster.
DR CTD; 31127; -.
DR FlyBase; FBgn0023130; a6.
DR VEuPathDB; VectorBase:FBgn0023130; -.
DR eggNOG; ENOG502TCW8; Eukaryota.
DR HOGENOM; CLU_657691_0_0_1; -.
DR InParanoid; O46341; -.
DR OMA; PFYISPR; -.
DR OrthoDB; 1143481at2759; -.
DR PhylomeDB; O46341; -.
DR BioGRID-ORCS; 31127; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31127; -.
DR PRO; PR:O46341; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0023130; Expressed in egg cell and 22 other tissues.
DR ExpressionAtlas; O46341; baseline and differential.
DR Genevisible; O46341; DM.
DR GO; GO:0001700; P:embryonic development via the syncytial blastoderm; IEP:UniProtKB.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..409
FT /note="Protein a6"
FT /id="PRO_0000064407"
FT REGION 106..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 86
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 133
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 134
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 409 AA; 44077 MW; 46FA1A9F93D391AB CRC64;
MNQKHSEPFY ISPRLFDNRR LKRRRCRWME RLLEHQRICM ARMRDQVALA SKTDRQLSHL
QRRHVASTLQ PDVTIDLLSD DDETPSAGQP AAAGHNRLLI PAPGHRAHRT GRRQAPRRAA
THSYPVTDSI LITSDDEHNE QEPSSTARVR SQLSMRSPPP LAPLTQSETI EEVTVSLVPR
TSTTANCLTR VSGHPKPCRA STAASNGFAT AEGGEGGNET GCFLEVDVGG GITATLPDET
TVHTVIANRI YELSLSKLRE GLAFSGVPEY TNDLMPEQLQ KLSPALRAKV APLVAPSPPT
PISLKLSSDL SISLISDEDD CESTGPHVNG GVGTEPVHPV VVAAAEAHAA AKLLKQQQPQ
LSVVQHLQYV GGGLAAPVAL ALPVMAANPT SSASVVALPL QLPRRRKLG
