ID   PIP_BOVIN               Reviewed;         145 AA.
AC   P60986;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Prolactin-inducible protein homolog;
DE   AltName: Full=Prolactin-induced protein;
DE   Flags: Precursor;
GN   Name=PIP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14697523; DOI=10.1016/j.gene.2003.10.013;
RA   Osawa M., Horiuchi H., Tian W., Kaneko M.;
RT   "Divergent evolution of the prolactin-inducible protein gene and related
RT   genes in the mouse genome.";
RL   Gene 325:179-186(2004).
CC   -!- SUBUNIT: Monomer. Interacts with AZGP1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PIP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB098480; BAD04928.1; -; Genomic_DNA.
DR   RefSeq; NP_001074382.1; NM_001080913.1.
DR   RefSeq; XP_010802934.1; XM_010804632.1.
DR   AlphaFoldDB; P60986; -.
DR   SMR; P60986; -.
DR   STRING; 9913.ENSBTAP00000008743; -.
DR   PaxDb; P60986; -.
DR   GeneID; 613853; -.
DR   KEGG; bta:613853; -.
DR   CTD; 5304; -.
DR   InParanoid; P60986; -.
DR   OrthoDB; 1459895at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR007990; PIP.
DR   PANTHER; PTHR15096; PTHR15096; 1.
DR   Pfam; PF05326; SVA; 1.
DR   PIRSF; PIRSF002572; PIP-GCDFP-15; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..145
FT                   /note="Prolactin-inducible protein homolog"
FT                   /id="PRO_0000024286"
FT   MOD_RES         29
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P12273"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        66..92
FT                   /evidence="ECO:0000250"
FT   DISULFID        90..124
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   145 AA;  16448 MW;  E3918D295AE0F9C9 CRC64;
     MYSLHLLLRA SPAALLLILC LQLGTTKAQE DTTSRQLMTM DLQMLQIDTS EEATVVLEVS
     TDLRECMVVK AYLLSNIPIE GNFNYKFTSC LCNNYPRRFF WDLQTNSTVR ITAVVDVIRE
     LGICPDDWAV IPIKANRFSI TKSLP