PIP_GORGO
ID PIP_GORGO Reviewed; 146 AA.
AC A0A885; A0A887;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Prolactin-inducible protein homolog;
DE AltName: Full=Prolactin-induced protein;
DE Flags: Precursor;
GN Name=PIP;
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ILE-113 AND ARG-118.
RC STRAIN=Isolate T025, Isolate T026, and Isolate T027;
RX PubMed=16949771; DOI=10.1016/j.gene.2006.07.014;
RA Kitano T., Tian W., Umetsu K., Yuasa I., Yamazaki K., Saitou N., Osawa M.;
RT "Origin and evolution of gene for prolactin-induced protein.";
RL Gene 383:64-70(2006).
CC -!- SUBUNIT: Monomer. Interacts with AZGP1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PIP family. {ECO:0000305}.
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DR EMBL; AB251901; BAF35621.1; -; Genomic_DNA.
DR EMBL; AB251902; BAF35622.1; -; Genomic_DNA.
DR EMBL; AB251903; BAF35623.1; -; Genomic_DNA.
DR RefSeq; XP_004046436.1; XM_004046388.2.
DR AlphaFoldDB; A0A885; -.
DR SMR; A0A885; -.
DR STRING; 9593.ENSGGOP00000021000; -.
DR PRIDE; A0A885; -.
DR Ensembl; ENSGGOT00000027049; ENSGGOP00000021000; ENSGGOG00000022725.
DR GeneID; 101154336; -.
DR KEGG; ggo:101154336; -.
DR CTD; 5304; -.
DR eggNOG; ENOG502T2PG; Eukaryota.
DR GeneTree; ENSGT00390000002099; -.
DR HOGENOM; CLU_148761_0_0_1; -.
DR InParanoid; A0A885; -.
DR OMA; ECMVIKT; -.
DR OrthoDB; 1459895at2759; -.
DR Proteomes; UP000001519; Chromosome 7.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019864; F:IgG binding; IEA:Ensembl.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl.
DR GO; GO:0070233; P:negative regulation of T cell apoptotic process; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR007990; PIP.
DR PANTHER; PTHR15096; PTHR15096; 1.
DR Pfam; PF05326; SVA; 1.
DR PIRSF; PIRSF002572; PIP-GCDFP-15; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000250"
FT CHAIN 29..146
FT /note="Prolactin-inducible protein homolog"
FT /id="PRO_0000273194"
FT MOD_RES 29
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P12273"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 65..91
FT /evidence="ECO:0000250"
FT DISULFID 89..123
FT /evidence="ECO:0000250"
FT VARIANT 113
FT /note="V -> I"
FT /evidence="ECO:0000269|PubMed:16949771"
FT /id="VAR_030099"
FT VARIANT 118
FT /note="Q -> R"
FT /evidence="ECO:0000269|PubMed:16949771"
FT /id="VAR_030100"
SQ SEQUENCE 146 AA; 16503 MW; 435343331212C04E CRC64;
MRLLQLLFRA SPATLLLVLC LQLGANKAQD NTRKIIIKNF DIPKSVRPND EVTAVLAVQT
ELKECMVVKT YLISSVPLQG AFNYKYTACL CDDNPKTFYW DFYANRTVQI AAVIDVIQEL
GICPDDAAVI PIKNNRFYTT EILEVE
