ID   PIP_LACLL               Reviewed;         901 AA.
AC   P49022;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Phage infection protein;
GN   Name=pip;
OS   Lactococcus lactis subsp. lactis (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1360;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C2;
RX   PubMed=8366036; DOI=10.1128/jb.175.17.5510-5519.1993;
RA   Geller B.L., Ivey R.G., Trempy J.E., Hettinger-Smith B.;
RT   "Cloning of a chromosomal gene required for phage infection of Lactococcus
RT   lactis subsp. lactis C2.";
RL   J. Bacteriol. 175:5510-5519(1993).
CC   -!- FUNCTION: Required for phage infection.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
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DR   EMBL; L14679; AAA03165.1; -; Unassigned_DNA.
DR   PIR; A48653; A48653.
DR   AlphaFoldDB; P49022; -.
DR   TCDB; 3.A.1.155.1; the atp-binding cassette (abc) superfamily.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR017501; Phage_infect_YhgE_C.
DR   InterPro; IPR017500; Phage_infect_YhgE_N.
DR   Pfam; PF01061; ABC2_membrane; 1.
DR   TIGRFAMs; TIGR03062; pip_yhgE_Cterm; 1.
DR   TIGRFAMs; TIGR03061; pip_yhgE_Nterm; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..901
FT                   /note="Phage infection protein"
FT                   /id="PRO_0000183012"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        701..721
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        747..767
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        778..798
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        805..825
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        860..880
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          701..880
FT                   /note="ABC transmembrane type-2"
SQ   SEQUENCE   901 AA;  99452 MW;  E30C84808B176097 CRC64;
     MKSIKNTWKL FALDWKRIFK NPVATFLIVA LMIIPSLYAW FNIKALWDPY ANTSQLPIAV
     YSADKPASFQ DKTINIGDEV LKNLKKNHQL GWKFVDSKAE LDKGVKSGKY YAGIYLPKDF
     SKDLLSFTTG DIKKPQIVYS INEKINAIAP KITSKGASSL QSQISEEFIN TASSTLLKTF
     NTIGYDIDKN MVSIQKVKSA ILSTNDNLGT IDKYTQQVVD LHGKMPEIKE KLAKANEFIT
     YLPEVDSLGQ KVISLNDKMP EIDKSLSLVL TLQEKIPEIQ NAGKQISMID EDFASVESTM
     TQGIQEAKDG LQIINQVQKS MPDIQKLGQD ADSLGTVTLD AAKKMQSALP SITNSVQITL
     QSIQEFSKNT SSVLAVIDQA IADNQLTDEE KEQINSLITN FINNIARQRE AIQNIVDYMK
     QVQESNGSHD LDSTIEQLSN LDSLLSGLST RMNHLNELVQ NGDVSEIRAY LSQINDVVTK
     ISNLVDNIDV SGISKTIDTV LTSLTKTIAD AKGLLNQAQQ IDFEALLNST SQTVSNAVTI
     LEKYQGEMPA IKQEIHDANL MLNGNMTTIV NAINEGASLY KNEFPILKTK LGTASDFFKN
     DYAGVRKDLT DTLTMANEKM PDVESALNQA NSLIQNDWPE IKSGIQKAAT AIQKGEKEVD
     LGEIVKLLKL DATKESDFWT QPVEVQENQV YPIANNGSAS TPFYTALCLW VGAVLLSSLA
     TTEVHLSDKD KKRYSKREQF FARMGSFVAI GLAQALIVTL GNYFGLGVDV RDPFYSVLFA
     LLISIAFMIM VYVLVALFGN VGKGIAIIIL VLSISGGGGN YPIQVSGKFF QAINPYLPFT
     HAVNLLRESA GGIYWPNAWF AIIILVAVSI IFVAIGAILF PHFEDKTKKI SEIGSKSHFF
     H