PIP_MOUSE
ID PIP_MOUSE Reviewed; 146 AA.
AC P02816; Q64013; Q8K127; Q9QUG8;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2004, sequence version 3.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Prolactin-inducible protein homolog;
DE AltName: Full=14 kDa submandibular gland protein;
DE Short=SMGP;
DE AltName: Full=Gross cystic disease fluid protein 15;
DE Short=GCDFP-15;
DE AltName: Full=Prolactin-induced protein;
DE Flags: Precursor;
GN Name=Pip;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Submandibular gland;
RX PubMed=7925123; DOI=10.1210/endo.135.4.7925123;
RA Myal Y., Iwasiow B., Yarmill A., Harrison E., Paterson J.A., Shiu R.P.;
RT "Tissue-specific androgen-inhibited gene expression of a submaxillary gland
RT protein, a rodent homolog of the human prolactin-inducible protein/GCDFP-15
RT gene.";
RL Endocrinology 135:1605-1610(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Submandibular gland;
RX PubMed=6546617; DOI=10.1093/nar/12.3.1361;
RA Windass J.D., Mullins J.J., Beecroft L.J., George H., Meacock P.A.,
RA Williams B.R.G., Brammar W.J.;
RT "Molecular cloning of cDNAs from androgen-independent mRNA species of DBA/2
RT mouse sub-maxillary glands.";
RL Nucleic Acids Res. 12:1361-1376(1984).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=DBA-2;
RA Osawa M., Huang X., Yukawa N., Saito T., Kusakabe T., Takeichi S.;
RT "Human gross cystic disease fluid protein 15 homologue in mice: sequential
RT and structural similarities to the mouse seminal vesicle autoantigen.";
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Monomer. Interacts with AZGP1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Lacrimal and submaxillary glands.
CC -!- SIMILARITY: Belongs to the PIP family. {ECO:0000305}.
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DR EMBL; S73282; AAB31990.2; -; mRNA.
DR EMBL; X02510; CAA26346.1; -; mRNA.
DR EMBL; AB017907; BAA75745.1; -; mRNA.
DR EMBL; AB017918; BAA75747.1; -; Genomic_DNA.
DR EMBL; BC028889; AAH28889.1; -; mRNA.
DR CCDS; CCDS39469.1; -.
DR PIR; A03299; WMMS14.
DR RefSeq; NP_032869.2; NM_008843.3.
DR AlphaFoldDB; P02816; -.
DR SMR; P02816; -.
DR STRING; 10090.ENSMUSP00000074818; -.
DR PhosphoSitePlus; P02816; -.
DR PaxDb; P02816; -.
DR PRIDE; P02816; -.
DR ProteomicsDB; 288167; -.
DR Antibodypedia; 2216; 631 antibodies from 41 providers.
DR Ensembl; ENSMUST00000075351; ENSMUSP00000074818; ENSMUSG00000058499.
DR GeneID; 18716; -.
DR KEGG; mmu:18716; -.
DR UCSC; uc009bqh.1; mouse.
DR CTD; 5304; -.
DR MGI; MGI:102696; Pip.
DR VEuPathDB; HostDB:ENSMUSG00000058499; -.
DR eggNOG; ENOG502T2PG; Eukaryota.
DR GeneTree; ENSGT00390000002099; -.
DR HOGENOM; CLU_148761_0_0_1; -.
DR InParanoid; P02816; -.
DR OMA; ECMVIKT; -.
DR OrthoDB; 1459895at2759; -.
DR PhylomeDB; P02816; -.
DR TreeFam; TF336919; -.
DR Reactome; R-MMU-5223345; Miscellaneous transport and binding events.
DR BioGRID-ORCS; 18716; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Msmb; mouse.
DR PRO; PR:P02816; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P02816; protein.
DR Bgee; ENSMUSG00000058499; Expressed in parotid gland and 22 other tissues.
DR ExpressionAtlas; P02816; baseline and differential.
DR Genevisible; P02816; MM.
DR GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0019864; F:IgG binding; ISO:MGI.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR GO; GO:0070233; P:negative regulation of T cell apoptotic process; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:0006508; P:proteolysis; ISO:MGI.
DR GO; GO:0002682; P:regulation of immune system process; IMP:MGI.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR007990; PIP.
DR PANTHER; PTHR15096; PTHR15096; 1.
DR Pfam; PF05326; SVA; 1.
DR PIRSF; PIRSF002572; PIP-GCDFP-15; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000250"
FT CHAIN 27..146
FT /note="Prolactin-inducible protein homolog"
FT /id="PRO_0000024290"
FT MOD_RES 27
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P12273"
FT DISULFID 65..91
FT /evidence="ECO:0000250"
FT DISULFID 89..123
FT /evidence="ECO:0000250"
FT CONFLICT 1..21
FT /note="MQGLSFTFSAVTLFLVLCLQL -> MSAA (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 2
FT /note="Q -> K (in Ref. 3; BAA75745/BAA75747)"
FT /evidence="ECO:0000305"
FT CONFLICT 135
FT /note="N -> S (in Ref. 1; AAB31990)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 146 AA; 16823 MW; B2257D1772C64531 CRC64;
MQGLSFTFSA VTLFLVLCLQ LGIIESQDDE NVRKPLLIEI DVPSTAQENQ EITVQVTVET
QYRECMVIKA YLVSNEPMEG AFNYVQTRCL CNDHPIRFFW DIIITRTVTF ATVIDIVREK
NICPNDMAVV PITANRYYTY NTVRMN
