PIP_PANTR
ID PIP_PANTR Reviewed; 146 AA.
AC P60989; A0A883;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Prolactin-inducible protein homolog;
DE AltName: Full=Prolactin-induced protein;
DE Flags: Precursor;
GN Name=PIP;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14697523; DOI=10.1016/j.gene.2003.10.013;
RA Osawa M., Horiuchi H., Tian W., Kaneko M.;
RT "Divergent evolution of the prolactin-inducible protein gene and related
RT genes in the mouse genome.";
RL Gene 325:179-186(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate T028, and Isolate T030;
RX PubMed=16949771; DOI=10.1016/j.gene.2006.07.014;
RA Kitano T., Tian W., Umetsu K., Yuasa I., Yamazaki K., Saitou N., Osawa M.;
RT "Origin and evolution of gene for prolactin-induced protein.";
RL Gene 383:64-70(2006).
CC -!- SUBUNIT: Monomer. Interacts with AZGP1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PIP family. {ECO:0000305}.
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DR EMBL; AB098482; BAD04930.1; -; Genomic_DNA.
DR EMBL; AB251899; BAF35619.1; -; Genomic_DNA.
DR EMBL; AB251900; BAF35620.1; -; Genomic_DNA.
DR RefSeq; NP_001009170.1; NM_001009170.1.
DR AlphaFoldDB; P60989; -.
DR SMR; P60989; -.
DR STRING; 9598.ENSPTRP00000033915; -.
DR PaxDb; P60989; -.
DR Ensembl; ENSPTRT00000036677; ENSPTRP00000033915; ENSPTRG00000019801.
DR GeneID; 494144; -.
DR KEGG; ptr:494144; -.
DR CTD; 5304; -.
DR VGNC; VGNC:8733; PIP.
DR eggNOG; ENOG502T2PG; Eukaryota.
DR GeneTree; ENSGT00390000002099; -.
DR HOGENOM; CLU_148761_0_0_1; -.
DR InParanoid; P60989; -.
DR OMA; ECMVIKT; -.
DR OrthoDB; 1459895at2759; -.
DR TreeFam; TF336919; -.
DR Proteomes; UP000002277; Chromosome 7.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019864; F:IgG binding; IEA:Ensembl.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl.
DR GO; GO:0070233; P:negative regulation of T cell apoptotic process; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR007990; PIP.
DR PANTHER; PTHR15096; PTHR15096; 1.
DR Pfam; PF05326; SVA; 1.
DR PIRSF; PIRSF002572; PIP-GCDFP-15; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000250"
FT CHAIN 29..146
FT /note="Prolactin-inducible protein homolog"
FT /id="PRO_0000024291"
FT MOD_RES 29
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P12273"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 65..91
FT /evidence="ECO:0000250"
FT DISULFID 89..123
FT /evidence="ECO:0000250"
SQ SEQUENCE 146 AA; 16575 MW; 792863048C9E8BF0 CRC64;
MRLFQLLFRA SPATLLLVLC LQLGANKAQD NTRKIIIHNF DIPKSVRPND EVTAVLAVQT
ELKECMVVKT YLISSIPLQG AFNYKYTACL CDDNPKTFYW DFYTNRTVQI AAVVDVIQEL
GICPDDAAVI PIKNNRFYTT EILKVE
