ID   PIP_RABIT               Reviewed;         146 AA.
AC   P60990;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Prolactin-inducible protein homolog;
DE   AltName: Full=Prolactin-induced protein;
DE   Flags: Precursor;
GN   Name=PIP;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14697523; DOI=10.1016/j.gene.2003.10.013;
RA   Osawa M., Horiuchi H., Tian W., Kaneko M.;
RT   "Divergent evolution of the prolactin-inducible protein gene and related
RT   genes in the mouse genome.";
RL   Gene 325:179-186(2004).
CC   -!- SUBUNIT: Monomer. Interacts with AZGP1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the PIP family. {ECO:0000305}.
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DR   EMBL; AB098478; BAD04926.1; -; Genomic_DNA.
DR   RefSeq; NP_001164587.1; NM_001171116.1.
DR   AlphaFoldDB; P60990; -.
DR   SMR; P60990; -.
DR   STRING; 9986.ENSOCUP00000005426; -.
DR   Ensembl; ENSOCUT00000006274; ENSOCUP00000005426; ENSOCUG00000006275.
DR   GeneID; 100328927; -.
DR   KEGG; ocu:100328927; -.
DR   CTD; 5304; -.
DR   eggNOG; ENOG502T2PG; Eukaryota.
DR   GeneTree; ENSGT00390000002099; -.
DR   InParanoid; P60990; -.
DR   Proteomes; UP000001811; Chromosome 7.
DR   Bgee; ENSOCUG00000006275; Expressed in prefrontal cortex.
DR   ExpressionAtlas; P60990; baseline.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0019864; F:IgG binding; IEA:Ensembl.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl.
DR   GO; GO:0070233; P:negative regulation of T cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0006508; P:proteolysis; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR007990; PIP.
DR   PANTHER; PTHR15096; PTHR15096; 1.
DR   Pfam; PF05326; SVA; 1.
DR   PIRSF; PIRSF002572; PIP-GCDFP-15; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..146
FT                   /note="Prolactin-inducible protein homolog"
FT                   /id="PRO_0000024292"
FT   CARBOHYD        105
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        65..91
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..123
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   146 AA;  16871 MW;  5346DA3252FB3AFD CRC64;
     MRALQFLLRV SPAFLLLVLC LQLEINKAEE SIWKVIQMDL QMPTVAVANE EVTVKLGIQT
     ELKECMVIKA YLRSNIQIDG PFNYRYTSCL CDDYPRTFYW DLVANRTATI AAVVDIIREL
     DICPEDRAVV PIKSNRYYVL HRLNVS