ID   PIP_RAT                 Reviewed;         146 AA.
AC   O70417;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Prolactin-inducible protein homolog;
DE   AltName: Full=Prolactin-induced protein;
DE   Flags: Precursor;
GN   Name=Pip;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Salivary gland;
RX   PubMed=9705972; DOI=10.1177/002215549804600910;
RA   Mirels L., Hand A.R., Branin H.J.;
RT   "Expression of gross cystic disease fluid protein-15/Prolactin-inducible
RT   protein in rat salivary glands.";
RL   J. Histochem. Cytochem. 46:1061-1071(1998).
CC   -!- SUBUNIT: Monomer. Interacts with AZGP1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PIP family. {ECO:0000305}.
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DR   EMBL; AF054270; AAC08020.1; -; mRNA.
DR   RefSeq; NP_073199.1; NM_022708.2.
DR   AlphaFoldDB; O70417; -.
DR   SMR; O70417; -.
DR   STRING; 10116.ENSRNOP00000021576; -.
DR   GlyGen; O70417; 1 site.
DR   PaxDb; O70417; -.
DR   GeneID; 64673; -.
DR   KEGG; rno:64673; -.
DR   UCSC; RGD:70946; rat.
DR   CTD; 5304; -.
DR   RGD; 70946; Pip.
DR   eggNOG; ENOG502T2PG; Eukaryota.
DR   InParanoid; O70417; -.
DR   OrthoDB; 1459895at2759; -.
DR   PhylomeDB; O70417; -.
DR   Reactome; R-RNO-5223345; Miscellaneous transport and binding events.
DR   PRO; PR:O70417; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR   GO; GO:0005576; C:extracellular region; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0019864; F:IgG binding; ISO:RGD.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:RGD.
DR   GO; GO:0070233; P:negative regulation of T cell apoptotic process; ISO:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   GO; GO:0006508; P:proteolysis; ISO:RGD.
DR   GO; GO:0002682; P:regulation of immune system process; ISO:RGD.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR007990; PIP.
DR   PANTHER; PTHR15096; PTHR15096; 1.
DR   Pfam; PF05326; SVA; 1.
DR   PIRSF; PIRSF002572; PIP-GCDFP-15; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..146
FT                   /note="Prolactin-inducible protein homolog"
FT                   /id="PRO_0000024293"
FT   MOD_RES         27
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P12273"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        65..91
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..123
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   146 AA;  16439 MW;  FABDE3438BB8DB99 CRC64;
     MQGLSFTSTA ATFFLVLCLQ LGINEGQDNE TIPQPLLFQL NVPSTPDENQ EVDMSLTLQT
     QYKECLVVKA YLISNTPVDG GFNYIQTRCI CNDHPTTLYW TFVVTQTLTF RIMVDIVKDK
     GICPNNVAVV PISGNRYFTD RTVYVN