ID   PIRC1_BOVIN             Reviewed;         136 AA.
AC   Q32P67;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Piercer of microtubule wall 1 protein;
DE            Short=Pierce1;
DE   AltName: Full=UPF0691 protein C9orf116 homolog;
GN   Name=PIERCE1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007744|PDB:7RRO}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), SUBCELLULAR LOCATION,
RP   TISSUE SPECIFICITY, INTERACTION WITH CFAP53; ODAD1 AND ODAD3, AND FUNCTION.
RX   PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA   Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA   Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA   Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT   "De novo identification of mammalian ciliary motility proteins using cryo-
RT   EM.";
RL   Cell 184:5791-5806.e19(2021).
CC   -!- FUNCTION: Microtubule inner protein involved in the attachment of outer
CC       dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in
CC       cilia axoneme, which is required for motile cilia beating. Functions at
CC       the initial step of left-right asymmetry specification of the visceral
CC       organs. {ECO:0000305|PubMed:34715025}.
CC   -!- SUBUNIT: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link
CC       the outer dynein arms docking complex (ODA-DC) to the internal
CC       microtubule inner proteins (MIP) in cilium axoneme.
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- SIMILARITY: Belongs to the PIERCE1 family. {ECO:0000305}.
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DR   EMBL; BC108239; AAI08240.1; -; mRNA.
DR   RefSeq; NP_001032568.1; NM_001037491.2.
DR   PDB; 7RRO; EM; 3.40 A; y/z=1-136.
DR   PDBsum; 7RRO; -.
DR   AlphaFoldDB; Q32P67; -.
DR   STRING; 9913.ENSBTAP00000032531; -.
DR   PaxDb; Q32P67; -.
DR   Ensembl; ENSBTAT00000076760; ENSBTAP00000065041; ENSBTAG00000049410.
DR   GeneID; 618654; -.
DR   KEGG; bta:618654; -.
DR   CTD; 138162; -.
DR   VEuPathDB; HostDB:ENSBTAG00000049410; -.
DR   VGNC; VGNC:102817; PIERCE1.
DR   eggNOG; ENOG502S22V; Eukaryota.
DR   GeneTree; ENSGT00940000154745; -.
DR   HOGENOM; CLU_135708_0_0_1; -.
DR   InParanoid; Q32P67; -.
DR   OMA; DYYRVSE; -.
DR   OrthoDB; 1574929at2759; -.
DR   TreeFam; TF323876; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000049410; Expressed in oviduct epithelium and 107 other tissues.
DR   GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
DR   GO; GO:0071494; P:cellular response to UV-C; IEA:Ensembl.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   GO; GO:0007368; P:determination of left/right symmetry; ISS:UniProtKB.
DR   GO; GO:0061966; P:establishment of left/right asymmetry; ISS:UniProtKB.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   InterPro; IPR026507; UPF0691.
DR   PANTHER; PTHR20899; PTHR20899; 1.
DR   Pfam; PF14892; DUF4490; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..136
FT                   /note="Piercer of microtubule wall 1 protein"
FT                   /id="PRO_0000359779"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   136 AA;  15654 MW;  397F2F3164B3B835 CRC64;
     MSEEDPKACA EPEEPKAGPP PEKTSDWYRV SEDLPARFNN PAWFRGYRTK EPPSVYRTSN
     QAYGSRAPTV HEMPKVFYPN SYKFSRQVAV GGMFQNNTLN VYMEKSIVTG PDNYITSYDR
     LNFHPSYRVC RPSICD