PIRC1_DANRE
ID PIRC1_DANRE Reviewed; 137 AA.
AC B0UXH9;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Piercer of microtubule wall 2 protein;
DE Short=Pierce1;
DE AltName: Full=UPF0691 protein C9orf116 homolog;
GN Name=pierce1; ORFNames=si:ch211-248e11.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: Microtubule inner protein involved in the attachment of outer
CC dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in
CC cilia axoneme, which is required for motile cilia beating. Functions at
CC the initial step of left-right asymmetry specification of the visceral
CC organs. {ECO:0000250|UniProtKB:Q5BN45}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q32P67}.
CC -!- SIMILARITY: Belongs to the PIERCE1 family. {ECO:0000305}.
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DR EMBL; CR361566; CAQ14398.1; -; Genomic_DNA.
DR RefSeq; NP_001116715.1; NM_001123243.1.
DR AlphaFoldDB; B0UXH9; -.
DR STRING; 7955.ENSDARP00000076347; -.
DR PaxDb; B0UXH9; -.
DR PeptideAtlas; B0UXH9; -.
DR Ensembl; ENSDART00000081909; ENSDARP00000076347; ENSDARG00000058940.
DR GeneID; 557793; -.
DR KEGG; dre:557793; -.
DR ZFIN; ZDB-GENE-081104-197; si:ch211-248e11.2.
DR eggNOG; ENOG502S22V; Eukaryota.
DR GeneTree; ENSGT00940000154745; -.
DR HOGENOM; CLU_135708_0_0_1; -.
DR InParanoid; B0UXH9; -.
DR OMA; EYGRRAP; -.
DR OrthoDB; 1574929at2759; -.
DR PhylomeDB; B0UXH9; -.
DR TreeFam; TF323876; -.
DR PRO; PR:B0UXH9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000058940; Expressed in testis and 21 other tissues.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR GO; GO:0007368; P:determination of left/right symmetry; ISS:UniProtKB.
DR GO; GO:0061966; P:establishment of left/right asymmetry; ISS:UniProtKB.
DR InterPro; IPR026507; UPF0691.
DR PANTHER; PTHR20899; PTHR20899; 1.
DR Pfam; PF14892; DUF4490; 1.
PE 3: Inferred from homology;
KW Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..137
FT /note="Piercer of microtubule wall 2 protein"
FT /id="PRO_0000359781"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 137 AA; 15742 MW; 3464CF038CA3C34F CRC64;
MSTNEIKNDY SAKEETAGPG DSNTSEIKTS DVYKVDKNLP SRFNNPDCFR YSHKTTNPLY
RTTNQAYGSK KPTVHEMPTS FNGSRHRFSE HLLKSGMYRD NGFNTMLDKS RLSRPNETSV
FYDRINFHSL YHTAGKS