ID   PIRC1_SALSA             Reviewed;         141 AA.
AC   B5X5D0;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Piercer of microtubule wall 1 protein;
DE            Short=Pierce1;
DE   AltName: Full=UPF0691 protein C9orf116 homolog;
GN   Name=pierce1;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Microtubule inner protein involved in the attachment of outer
CC       dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in
CC       cilia axoneme, which is required for motile cilia beating. Functions at
CC       the initial step of left-right asymmetry specification of the visceral
CC       organs. {ECO:0000250|UniProtKB:Q5BN45}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q32P67}.
CC   -!- SIMILARITY: Belongs to the PIERCE1 family. {ECO:0000305}.
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DR   EMBL; BT046249; ACI66050.1; -; mRNA.
DR   RefSeq; NP_001134053.1; NM_001140581.1.
DR   AlphaFoldDB; B5X5D0; -.
DR   STRING; 8030.ENSSSAP00000078825; -.
DR   GeneID; 100195552; -.
DR   KEGG; sasa:100195552; -.
DR   CTD; 100195552; -.
DR   OrthoDB; 1574929at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa24.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   GO; GO:0007368; P:determination of left/right symmetry; ISS:UniProtKB.
DR   GO; GO:0061966; P:establishment of left/right asymmetry; ISS:UniProtKB.
DR   InterPro; IPR026507; UPF0691.
DR   PANTHER; PTHR20899; PTHR20899; 1.
DR   Pfam; PF14892; DUF4490; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..141
FT                   /note="Piercer of microtubule wall 1 protein"
FT                   /id="PRO_0000359782"
SQ   SEQUENCE   141 AA;  16181 MW;  E6A4CFAF508264DE CRC64;
     MGAGILRVII MDSENYVETH PSDDNEAMKT SDVYKVDKNL PKRFNNPDCF QGYSTKINHP
     FYQTSSQIYG SKRPTVHEMP TTFNGSYRKF SEHMLKSGMF RDNGFNTSIE KSKITGHDTI
     PMFQDRINFN YAYDSGNGPK N