PIRC2_HUMAN
ID PIRC2_HUMAN Reviewed; 121 AA.
AC H3BRN8;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Piercer of microtubule wall 2 protein {ECO:0000305};
GN Name=PIERCE2 {ECO:0000312|HGNC:HGNC:44654}; Synonyms=C15orf65;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Endometrium;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Microtubule inner protein involved in the attachment of outer
CC dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in
CC cilia axoneme, which is required for motile cilia beating.
CC {ECO:0000250|UniProtKB:V9GXK1}.
CC -!- SUBUNIT: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link
CC the outer dynein arms docking complex (ODA-DC) to the internal
CC microtubule inner proteins (MIP) in cilium axoneme.
CC {ECO:0000250|UniProtKB:A0A3Q1LFK7}.
CC -!- INTERACTION:
CC H3BRN8; Q2TAL8: QRICH1; NbExp=3; IntAct=EBI-18394323, EBI-2798044;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:A0A3Q1LFK7}.
CC -!- SIMILARITY: Belongs to the PIERCE2 family. {ECO:0000305}.
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DR EMBL; BX648577; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK130862; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC013355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471082; EAW77489.1; -; Genomic_DNA.
DR CCDS; CCDS58363.1; -.
DR RefSeq; NP_001185713.1; NM_001198784.1.
DR AlphaFoldDB; H3BRN8; -.
DR SMR; H3BRN8; -.
DR BioGRID; 126940; 1.
DR IntAct; H3BRN8; 1.
DR STRING; 9606.ENSP00000456337; -.
DR BioMuta; C15orf65; -.
DR MassIVE; H3BRN8; -.
DR PaxDb; H3BRN8; -.
DR PeptideAtlas; H3BRN8; -.
DR PRIDE; H3BRN8; -.
DR ProteomicsDB; 42122; -.
DR Antibodypedia; 73844; 5 antibodies from 5 providers.
DR DNASU; 145788; -.
DR Ensembl; ENST00000569691.2; ENSP00000456337.1; ENSG00000261652.3.
DR GeneID; 145788; -.
DR KEGG; hsa:145788; -.
DR MANE-Select; ENST00000569691.2; ENSP00000456337.1; NM_001198784.2; NP_001185713.1.
DR UCSC; uc002ada.4; human.
DR CTD; 145788; -.
DR GeneCards; C15orf65; -.
DR HGNC; HGNC:44654; PIERCE2.
DR HPA; ENSG00000261652; Low tissue specificity.
DR MIM; 619669; gene.
DR neXtProt; NX_H3BRN8; -.
DR OpenTargets; ENSG00000261652; -.
DR VEuPathDB; HostDB:ENSG00000261652; -.
DR eggNOG; ENOG502S7B5; Eukaryota.
DR GeneTree; ENSGT00940000154745; -.
DR HOGENOM; CLU_153970_0_0_1; -.
DR InParanoid; H3BRN8; -.
DR OMA; MIMYKTS; -.
DR OrthoDB; 1488437at2759; -.
DR PhylomeDB; H3BRN8; -.
DR TreeFam; TF323876; -.
DR PathwayCommons; H3BRN8; -.
DR SignaLink; H3BRN8; -.
DR BioGRID-ORCS; 145788; 11 hits in 967 CRISPR screens.
DR ChiTaRS; C15orf65; human.
DR GenomeRNAi; 145788; -.
DR Pharos; H3BRN8; Tdark.
DR PRO; PR:H3BRN8; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; H3BRN8; protein.
DR Bgee; ENSG00000261652; Expressed in bronchial epithelial cell and 159 other tissues.
DR Genevisible; H3BRN8; HS.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR GO; GO:0007368; P:determination of left/right symmetry; ISS:UniProtKB.
DR InterPro; IPR026507; UPF0691.
DR PANTHER; PTHR20899; PTHR20899; 1.
DR Pfam; PF14892; DUF4490; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..121
FT /note="Piercer of microtubule wall 2 protein"
FT /id="PRO_0000423417"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 5
FT /note="N -> K (in Ref. 1; BX648577)"
FT /evidence="ECO:0000305"
FT CONFLICT 10
FT /note="S -> G (in Ref. 1; BX648577)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 121 AA; 13763 MW; 7B799AC08A1B561A CRC64;
MTDRNRDKKS TSPSNSDTEM KSEQLPPCVN PGNPVFSCML DPKTLQTATS LSKPQMIMYK
TNSSHYGEFL PIPQFFPCNY TPKEQVFSSH IRATGFYQNN TLNTAPDRTR TLDFPNIQHT
L
