ID   PIRL2_ARATH             Reviewed;         471 AA.
AC   Q9LRV8;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Plant intracellular Ras-group-related LRR protein 2;
GN   Name=PIRL2; OrderedLocusNames=At3g26500; ORFNames=MFE16.1;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, MOTIF GVYW, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=15809230; DOI=10.1093/pcp/pci097;
RA   Forsthoefel N.R., Cutler K., Port M.D., Yamamoto T., Vernon D.M.;
RT   "PIRLs: a novel class of plant intracellular leucine-rich repeat
RT   proteins.";
RL   Plant Cell Physiol. 46:913-922(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: Leucine-rich repeat protein that likely mediates protein
CC       interactions, possibly in the context of signal transduction.
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Widely expressed but preferentially in roots.
CC       {ECO:0000269|PubMed:15809230}.
CC   -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
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DR   EMBL; AY849572; AAW57411.1; -; mRNA.
DR   EMBL; AB028611; BAB01830.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE77167.1; -; Genomic_DNA.
DR   EMBL; AK119000; BAC43576.1; -; mRNA.
DR   EMBL; BT006050; AAP04035.1; -; mRNA.
DR   RefSeq; NP_189281.2; NM_113557.3.
DR   AlphaFoldDB; Q9LRV8; -.
DR   SMR; Q9LRV8; -.
DR   STRING; 3702.AT3G26500.1; -.
DR   PaxDb; Q9LRV8; -.
DR   PRIDE; Q9LRV8; -.
DR   ProteomicsDB; 236741; -.
DR   EnsemblPlants; AT3G26500.1; AT3G26500.1; AT3G26500.
DR   GeneID; 822257; -.
DR   Gramene; AT3G26500.1; AT3G26500.1; AT3G26500.
DR   KEGG; ath:AT3G26500; -.
DR   Araport; AT3G26500; -.
DR   TAIR; locus:2088807; AT3G26500.
DR   eggNOG; KOG0619; Eukaryota.
DR   HOGENOM; CLU_021557_0_0_1; -.
DR   InParanoid; Q9LRV8; -.
DR   OMA; KEFMAKW; -.
DR   OrthoDB; 484111at2759; -.
DR   PhylomeDB; Q9LRV8; -.
DR   PRO; PR:Q9LRV8; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LRV8; baseline and differential.
DR   GO; GO:0055046; P:microgametogenesis; IGI:TAIR.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 8.
DR   PROSITE; PS51450; LRR; 9.
PE   2: Evidence at transcript level;
KW   Coiled coil; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..471
FT                   /note="Plant intracellular Ras-group-related LRR protein 2"
FT                   /id="PRO_0000423602"
FT   REPEAT          159..182
FT                   /note="LRR 1"
FT   REPEAT          183..205
FT                   /note="LRR 2"
FT   REPEAT          206..229
FT                   /note="LRR 3"
FT   REPEAT          231..251
FT                   /note="LRR 4"
FT   REPEAT          253..275
FT                   /note="LRR 5"
FT   REPEAT          276..298
FT                   /note="LRR 6"
FT   REPEAT          300..321
FT                   /note="LRR 7"
FT   REPEAT          324..346
FT                   /note="LRR 8"
FT   REPEAT          347..369
FT                   /note="LRR 9"
FT   REPEAT          371..392
FT                   /note="LRR 10"
FT   COILED          106..133
FT                   /evidence="ECO:0000255"
FT   MOTIF           393..405
FT                   /note="GVYW; degenerate"
SQ   SEQUENCE   471 AA;  52596 MW;  15F8F2D7F6F3312F CRC64;
     MDHDLDKFPL LSYVLHQHDS NLHAPPSMAA QETLLPSFPL LSNPEIMSML TQSIPTTITQ
     TLFVFNSLGS RPDPLAVSSA RFKIAQIMDS LSPEEAAKES EIYAGVVRLD EVHDSYEKKL
     KDTEEELSRV YSTEVESMLR SGEEVNEKVL AVLKEAESGG TVERIDLSSQ ELKLIPEAFW
     KVVGLVYLNL SGNDLTFIPD AISKLKKLEE LDVSSNSLES LPDSIGMLLN LRILNVNANN
     LTALPESIAH CRSLVELDAS YNNLTSLPTN IGYGLQNLER LSIQLNKLRY FPGSISEMYN
     LKYLDAHMNE IHGIPNSIGR LTKLEVLNLS SNFNNLMGVP DTITDLTNLR ELDLSNNQIQ
     AIPDSFYRLR KLEKLNLDQN PLEIPSQEVA TQGAEVVREF MRKRWGDIMA EQQQRIGVEA
     ERHGDENGWV YWGTSMVTNL VSGVTHTIGF GGATSDGGDK KPGDSYFYHQ I