ID   PIRL3_ARATH             Reviewed;         464 AA.
AC   Q8W4Q3; Q9LPV2;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Plant intracellular Ras-group-related LRR protein 3;
GN   Name=PIRL3; OrderedLocusNames=At1g12970; ORFNames=F13K23.23;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, MOTIF GVYW, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=15809230; DOI=10.1093/pcp/pci097;
RA   Forsthoefel N.R., Cutler K., Port M.D., Yamamoto T., Vernon D.M.;
RT   "PIRLs: a novel class of plant intracellular leucine-rich repeat
RT   proteins.";
RL   Plant Cell Physiol. 46:913-922(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: Leucine-rich repeat protein that likely mediates protein
CC       interactions, possibly in the context of signal transduction.
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:15809230}.
CC   -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF78502.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY849573; AAW57412.1; -; mRNA.
DR   EMBL; AC012187; AAF78502.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE28955.1; -; Genomic_DNA.
DR   EMBL; AY062103; AAL32979.1; -; mRNA.
DR   EMBL; AY124880; AAM70589.1; -; mRNA.
DR   PIR; F86263; F86263.
DR   RefSeq; NP_563921.1; NM_101168.2.
DR   AlphaFoldDB; Q8W4Q3; -.
DR   SMR; Q8W4Q3; -.
DR   STRING; 3702.AT1G12970.1; -.
DR   iPTMnet; Q8W4Q3; -.
DR   PaxDb; Q8W4Q3; -.
DR   PRIDE; Q8W4Q3; -.
DR   ProteomicsDB; 236742; -.
DR   EnsemblPlants; AT1G12970.1; AT1G12970.1; AT1G12970.
DR   GeneID; 837855; -.
DR   Gramene; AT1G12970.1; AT1G12970.1; AT1G12970.
DR   KEGG; ath:AT1G12970; -.
DR   Araport; AT1G12970; -.
DR   TAIR; locus:2010326; AT1G12970.
DR   eggNOG; KOG0619; Eukaryota.
DR   HOGENOM; CLU_021557_0_0_1; -.
DR   InParanoid; Q8W4Q3; -.
DR   OMA; QTLHVFA; -.
DR   OrthoDB; 484111at2759; -.
DR   PhylomeDB; Q8W4Q3; -.
DR   PRO; PR:Q8W4Q3; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8W4Q3; baseline and differential.
DR   Genevisible; Q8W4Q3; AT.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; HDA:TAIR.
DR   GO; GO:0055046; P:microgametogenesis; IGI:TAIR.
DR   GO; GO:0046777; P:protein autophosphorylation; HDA:TAIR.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   SMART; SM00369; LRR_TYP; 7.
DR   PROSITE; PS51450; LRR; 9.
PE   2: Evidence at transcript level;
KW   Coiled coil; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..464
FT                   /note="Plant intracellular Ras-group-related LRR protein 3"
FT                   /id="PRO_0000423603"
FT   REPEAT          160..183
FT                   /note="LRR 1"
FT   REPEAT          184..206
FT                   /note="LRR 2"
FT   REPEAT          207..230
FT                   /note="LRR 3"
FT   REPEAT          232..252
FT                   /note="LRR 4"
FT   REPEAT          254..275
FT                   /note="LRR 5"
FT   REPEAT          276..299
FT                   /note="LRR 6"
FT   REPEAT          301..322
FT                   /note="LRR 7"
FT   REPEAT          323..347
FT                   /note="LRR 8"
FT   REPEAT          348..370
FT                   /note="LRR 9"
FT   REPEAT          372..393
FT                   /note="LRR 10"
FT   COILED          106..138
FT                   /evidence="ECO:0000255"
FT   MOTIF           398..406
FT                   /note="GVYW; degenerate"
SQ   SEQUENCE   464 AA;  51648 MW;  DBE6F7D9FB7C4A4A CRC64;
     MDHDLEIFPL LSYVLHHSDP ASHAPPSLAI QQSLANRYPL LTNPYVISSL IESIPSTITQ
     TLFVFGSLGP RPDPLAVSSA RSKIREIKEN DSLSPEDAAK EEQVYAAVVS LEEVHEGYEK
     QLRDLEEEIG RVYASAVESL SGGDEVNEEV LAVIKDAEDG GVVERIDLSD HELKLLPDAL
     GKIVGLVSLN VSRNNLRFLP DTISGLEKLE ELDLSSNRLV FLPDSIGLLL NLRILNVTGN
     KLTLLPESIA QCRSLVELDA SFNNLTSLPA NFGYGLLNLE RLSIQLNKIR FFPNSICEMR
     SLRYLDAHMN EIHGLPIAIG RLTNLEVMNL SSNFSDLIEL PDTISDLANL RELDLSNNQI
     RVLPDSFFRL EKLEKLNLDQ NPLEYPPQEM VNQSAEAVRE FMRKRWEEMV EEEQLRSVIE
     AEKQQGGATG WLSWGSSIVT SLFSGGTHGG AAKKPKNSFL DEQL