PIRL8_ARATH
ID PIRL8_ARATH Reviewed; 383 AA.
AC Q8RWE5; Q9SZH9;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Plant intracellular Ras-group-related LRR protein 8;
GN Name=PIRL8; OrderedLocusNames=At4g26050; ORFNames=F20B18.160;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, MOTIF GVYW, AND TISSUE
RP SPECIFICITY.
RX PubMed=15809230; DOI=10.1093/pcp/pci097;
RA Forsthoefel N.R., Cutler K., Port M.D., Yamamoto T., Vernon D.M.;
RT "PIRLs: a novel class of plant intracellular leucine-rich repeat
RT proteins.";
RL Plant Cell Physiol. 46:913-922(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Leucine-rich repeat protein that likely mediates protein
CC interactions, possibly in the context of signal transduction.
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Widely expressed except flowers.
CC {ECO:0000269|PubMed:15809230}.
CC -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAW57417.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB39670.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB79460.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY849578; AAW57417.1; ALT_INIT; mRNA.
DR EMBL; AL049483; CAB39670.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL161564; CAB79460.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002687; AEE85149.1; -; Genomic_DNA.
DR EMBL; AY093142; AAM13141.1; -; mRNA.
DR EMBL; BT008469; AAP37828.1; -; mRNA.
DR PIR; T04260; T04260.
DR RefSeq; NP_194335.2; NM_118738.6.
DR AlphaFoldDB; Q8RWE5; -.
DR SMR; Q8RWE5; -.
DR STRING; 3702.AT4G26050.1; -.
DR iPTMnet; Q8RWE5; -.
DR PaxDb; Q8RWE5; -.
DR PRIDE; Q8RWE5; -.
DR ProteomicsDB; 235026; -.
DR EnsemblPlants; AT4G26050.1; AT4G26050.1; AT4G26050.
DR GeneID; 828711; -.
DR Gramene; AT4G26050.1; AT4G26050.1; AT4G26050.
DR KEGG; ath:AT4G26050; -.
DR Araport; AT4G26050; -.
DR TAIR; locus:2120825; AT4G26050.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_0_1; -.
DR InParanoid; Q8RWE5; -.
DR OMA; KKSWGIG; -.
DR OrthoDB; 1382533at2759; -.
DR PhylomeDB; Q8RWE5; -.
DR PRO; PR:Q8RWE5; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8RWE5; baseline and differential.
DR Genevisible; Q8RWE5; AT.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEP:TAIR.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR PROSITE; PS51450; LRR; 9.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..383
FT /note="Plant intracellular Ras-group-related LRR protein 8"
FT /id="PRO_0000423608"
FT REPEAT 56..79
FT /note="LRR 1"
FT REPEAT 80..102
FT /note="LRR 2"
FT REPEAT 104..126
FT /note="LRR 3"
FT REPEAT 127..149
FT /note="LRR 4"
FT REPEAT 151..173
FT /note="LRR 5"
FT REPEAT 174..197
FT /note="LRR 6"
FT REPEAT 199..219
FT /note="LRR 7"
FT REPEAT 221..244
FT /note="LRR 8"
FT REPEAT 245..268
FT /note="LRR 9"
FT REPEAT 270..290
FT /note="LRR 10"
FT MOTIF 291..298
FT /note="GVYW; degenerate"
SQ SEQUENCE 383 AA; 42440 MW; 49D492022B9F0E0C CRC64;
MMGYEQMNQM TMTTTAMMKN YNKKGLINTP QKKMTRRSVS AIDGGAAATA KEGDRRQNIK
TLDLSGMSLA SLSASSINLA SISKLDLSNN NIQKIPESLV ARMLNLWALD LQSNQLKTLP
NSIGCLSKLK FLNVSGNYLQ SLPKTIEDCR SLEELNANFN ELTRLPDAIG FELTNLTKLS
VNSNKLVLLP NSVSYLTSLR VLDARLNRLS SLPEDLENLV NLQVLNVSQN FQHLTTLPYS
VGLLISLVEL DVSYNGITVL PDSLGCLRRI QKLSVEGNPL ISPPFEVVEQ GLEALKQYMS
EKMTESYKKT PTKKKSWGIG KLVKYGLSSS PGRSTGREDG KEGFINVSDY RQIDGIASPR
HVSLFNPRRL LSPLSAYFSP PRY
