ID   PIS1_CARML              Reviewed;          62 AA.
AC   P80569; Q934J2;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Bacteriocin piscicolin-126;
DE   Flags: Precursor;
GN   Name=pisA;
OS   Carnobacterium maltaromaticum (Carnobacterium piscicola).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Carnobacteriaceae;
OC   Carnobacterium.
OX   NCBI_TaxID=2751;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=JG126;
RA   Gibbs G.M., Fitzgerald A., Selleck M.L., Harmark K., Hillier A.J.,
RA   Davidson B.E.;
RT   "Characterization of the genes involved in the production of piscicolin
RT   126, a bacteriocin from Carnobacterium piscicola JG126.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 19-62, AND MASS SPECTROMETRY.
RC   STRAIN=JG126;
RX   PubMed=8702282; DOI=10.1128/aem.62.8.2897-2903.1996;
RA   Jack R.W., Wan J., Gordon J., Harmark K., Davidson B.E., Hillier A.J.,
RA   Wettenhall R.E.H., Hickey M.W., Coventry J.M.;
RT   "Characterization of the chemical and antimicrobial properties of
RT   piscicolin 126, a bacteriocin produced by Carnobacterium piscicola JG126.";
RL   Appl. Environ. Microbiol. 62:2897-2903(1996).
CC   -!- FUNCTION: Inhibits the growth of several Gram-positive bacteria,
CC       especially the food-borne pathogen L.monocytogenes, but has no effect
CC       on the growth of a number of yeasts and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=4416.6; Mass_error=1.9; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:8702282};
CC   -!- SIMILARITY: Belongs to the bacteriocin class IIA/YGNGV family.
CC       {ECO:0000305}.
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DR   EMBL; AF275938; AAK69419.1; -; Genomic_DNA.
DR   RefSeq; WP_057000613.1; NZ_JQBV01000002.1.
DR   AlphaFoldDB; P80569; -.
DR   SMR; P80569; -.
DR   TCDB; 1.C.24.1.3; the pediocin (pediocin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.130; -; 1.
DR   InterPro; IPR002633; Bacteriocin_IIa.
DR   InterPro; IPR023384; Bacteriocin_IIa_CS.
DR   InterPro; IPR023388; Bacteriocin_IIa_dom_sf.
DR   Pfam; PF01721; Bacteriocin_II; 1.
DR   PROSITE; PS60030; BACTERIOCIN_IIA; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Disulfide bond; Secreted.
FT   PROPEP          1..18
FT                   /evidence="ECO:0000269|PubMed:8702282"
FT                   /id="PRO_0000002738"
FT   CHAIN           19..62
FT                   /note="Bacteriocin piscicolin-126"
FT                   /id="PRO_0000002739"
FT   DISULFID        27..32
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   62 AA;  6380 MW;  A58659284A54E9A3 CRC64;
     MKTVKELSVK EMQLTTGGKY YGNGVSCNKN GCTVDWSKAI GIIGNNAAAN LTTGGAAGWN
     KG