PIT1_ONCKE
ID PIT1_ONCKE Reviewed; 365 AA.
AC Q91169;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Pituitary-specific positive transcription factor 1;
DE Short=PIT-1;
DE AltName: Full=Growth hormone factor 1;
DE Short=GHF-1;
GN Name=pou1f1; Synonyms=pit1;
OS Oncorhynchus keta (Chum salmon) (Salmo keta).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8018;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1634120; DOI=10.1016/0378-1119(92)90525-t;
RA Ono M., Takayama Y.;
RT "Structures of cDNAs encoding chum salmon pituitary-specific transcription
RT factor, Pit-1/GHF-1.";
RL Gene 116:275-279(1992).
CC -!- FUNCTION: Transcription factor that activates growth hormone and
CC prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-
CC 3'. {ECO:0000250|UniProtKB:P28069}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P28069}.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000250|UniProtKB:P28069}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-1
CC subfamily. {ECO:0000305}.
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DR EMBL; D10444; BAA01234.1; -; mRNA.
DR PIR; JC1168; JC1168.
DR AlphaFoldDB; Q91169; -.
DR SMR; Q91169; -.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR015586; Pit_1.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR PANTHER; PTHR11636:SF84; PTHR11636:SF84; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; Nucleus; Transcription;
KW Transcription regulation.
FT CHAIN 1..365
FT /note="Pituitary-specific positive transcription factor 1"
FT /id="PRO_0000100705"
FT DOMAIN 188..262
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 278..337
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 160..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 5..12
FT /note="9aaTAD"
FT /evidence="ECO:0000250|UniProtKB:P28069"
FT COMPBIAS 171..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 40333 MW; D75D74842E8FE54A CRC64;
MSCQAFSADS FTTLAGDSLP LLMHHASAAD CLPSSASTHT HNMVSAVPSG LSLLQSSKRS
HMHLSTSTLG NGPPGLHYPV TPCHYSNQQT TYGMMAAQEM LSASISQTRI LQTCSVPHPN
MVNGANTLQG SLAPCLYKFP EHGLGGGSCS LSHSFPPLPP AVLSEEPPLG GTKDLRLRSR
PPDDPPDMDS PQIRELEKFA NNFKLRRIKL GYTQTNVGEA LAAVHGSEFS QTTICRFENL
QLSFKNACTL KAILAKWLDE AEQAGALFNE KMGMNERKRK RRTTISLGAK EALERSFREK
IKPSSQEIVR MAEGLHLEKE VVRVWFCNRR QREKRVKTSL HHSSYLTKDS PTYRYPYLSP
NAIKP
