ID   PIT1_SHEEP              Reviewed;         291 AA.
AC   P79364;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Pituitary-specific positive transcription factor 1;
DE            Short=PIT-1;
DE   AltName: Full=Growth hormone factor 1;
DE            Short=GHF-1;
GN   Name=POU1F1; Synonyms=PIT-1, PIT1;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Thomas M.G., Raymond S.R., Carroll J.A., Matteri R.L., Hillman L.,
RA   Chanetsa F., Rozeboom K.J., Lipsey R.J., Keisler D.H.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in the specification of the
CC       lactotrope, somatotrope, and thyrotrope phenotypes in the developing
CC       anterior pituitary. Activates growth hormone and prolactin genes.
CC       Specifically binds to the consensus sequence 5'-TAAAT-3'.
CC       {ECO:0000250|UniProtKB:P28069}.
CC   -!- SUBUNIT: Interacts with PITX1. Interacts with LHX3. Interacts with
CC       ELK1. {ECO:0000250|UniProtKB:P28069}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P28069}.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000250|UniProtKB:P28069}.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U88399; AAB48500.1; -; mRNA.
DR   RefSeq; NP_001009350.1; NM_001009350.1.
DR   AlphaFoldDB; P79364; -.
DR   SMR; P79364; -.
DR   STRING; 9940.ENSOARP00000018309; -.
DR   GeneID; 443370; -.
DR   KEGG; oas:443370; -.
DR   CTD; 5449; -.
DR   eggNOG; KOG3802; Eukaryota.
DR   OrthoDB; 797288at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR015586; Pit_1.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   PANTHER; PTHR11636:SF84; PTHR11636:SF84; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..291
FT                   /note="Pituitary-specific positive transcription factor 1"
FT                   /id="PRO_0000100702"
FT   DOMAIN          124..198
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        214..273
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   MOTIF           5..13
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000250|UniProtKB:P28069"
SQ   SEQUENCE   291 AA;  33051 MW;  01E1D7113280530E CRC64;
     MSCQPFTSTD TFIPLNSESS ATLPLIMHPS AAECLPVSNH ATNVMSTATG LHYSVPSCHY
     GNQSSTYGVM AGSLTPCLYE FPDHTLSHGF PPMHQPLLSE DPTAADFKQE LRRKSKLIEE
     PIDMDSPEIR ELEKFANEFK VRRIKLGYTQ TNVGEALAAV HGSEFSQTTI CRFENLQLSF
     KNACKLKAIL FKWLEEAEQV GALYNEKVGA NERKRKRRTT ISIAAKDALE RHFGEQNKPS
     SQEILRMAEE LNLEKEVVRV WFCNRRQREK RVKTSLNQSL FPNSKEHLEC R