ID   PITC_DICDI              Reviewed;         364 AA.
AC   Q55CU8; O15915;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Phosphatidylinositol transfer protein 3;
DE   AltName: Full=CRAL-TRIO domain-containing protein pitC;
DE   AltName: Full=Random slug protein 5;
GN   Name=pitC {ECO:0000303|PubMed:10769190}; Synonyms=rsc5;
GN   ORFNames=DDB_G0269182;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX4;
RA   Iranfar N., Loomis W.F.;
RL   Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=10769190; DOI=10.1042/bj3470837;
RA   Swigart P., Insall R., Wilkins A., Cockcroft S.;
RT   "Purification and cloning of phosphatidylinositol transfer proteins from
RT   Dictyostelium discoideum: homologues of both mammalian PITPs and
RT   Saccharomyces cerevisiae sec14p are found in the same cell.";
RL   Biochem. J. 347:837-843(2000).
CC   -!- FUNCTION: Has phosphatidylinositol transfer activity (By similarity).
CC       {ECO:0000250|UniProtKB:P53860}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U82515; AAB69635.1; -; mRNA.
DR   EMBL; AAFI02000005; EAL71941.1; -; Genomic_DNA.
DR   RefSeq; XP_646383.1; XM_641291.1.
DR   AlphaFoldDB; Q55CU8; -.
DR   SMR; Q55CU8; -.
DR   STRING; 44689.DDB0216218; -.
DR   PaxDb; Q55CU8; -.
DR   PRIDE; Q55CU8; -.
DR   EnsemblProtists; EAL71941; EAL71941; DDB_G0269182.
DR   GeneID; 8617338; -.
DR   KEGG; ddi:DDB_G0269182; -.
DR   dictyBase; DDB_G0269182; pitC.
DR   eggNOG; KOG1470; Eukaryota.
DR   HOGENOM; CLU_761699_0_0_1; -.
DR   InParanoid; Q55CU8; -.
DR   OMA; CMENAIV; -.
DR   PhylomeDB; Q55CU8; -.
DR   PRO; PR:Q55CU8; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0008526; F:phosphatidylinositol transfer activity; IDA:dictyBase.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF03765; CRAL_TRIO_N; 1.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Reference proteome; Transport.
FT   CHAIN           1..364
FT                   /note="Phosphatidylinositol transfer protein 3"
FT                   /id="PRO_0000368228"
FT   DOMAIN          113..281
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   REGION          290..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..364
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        304..324
FT                   /note="TETDSKKQKKEKKKEEKEKKK -> SCRIFFQFILLIYFINLIDFI (in
FT                   Ref. 1; AAB69635)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        325..364
FT                   /note="Missing (in Ref. 1; AAB69635)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   364 AA;  42386 MW;  68DEABD6FBF72599 CRC64;
     MESTASTSDS ASAITTGLSE VDINQQSPPI ILKEGEIFDP LKNLNEKQLE AFKEIKSNFS
     DLTDPTDIAF CTDMCFLRYL RARNYIVSKS EKMLRDTLEW RKKFRPQDIQ LGGDIREIGS
     AGCVYVNKRD KKGRPIIFAV PRNDTLKNVP SELKFKNLVY WLEQGFSRMD EPKGIEQFCF
     IVDYKDFGSG NMDMKTNLEA MHFLLDHCPE RMGQSLFLDP PALFWFAWKI ISPFLNEVTL
     SKVRFINSKK VDGKRTFAEL LEYVDIENLE QNLGGNLDYN YNIDEYLKEN PDPIVDTPPI
     TFSTETDSKK QKKEKKKEEK EKKKEEKEKK KEEKEEKKKE KEEKKKLKKE ASFTKQQENA
     DEVD