ID   PITE_DICDI              Reviewed;         287 AA.
AC   Q54VC7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Phosphatidylinositol transfer protein 5;
DE            Short=PtdIns transfer protein 5;
DE   AltName: Full=DdPITP3;
GN   Name=pitE; ORFNames=DDB_G0280449;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Phosphatidylinositol transfer proteins mediate the monomeric
CC       transport of lipids by shielding a lipid from the aqueous environment
CC       and binding the lipid in a hydrophobic cavity (By similarity).
CC       {ECO:0000250|UniProtKB:Q9UKF7}.
CC   -!- SIMILARITY: Belongs to the PtdIns transfer protein family. PI transfer
CC       class IIA subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000036; EAL67203.1; -; Genomic_DNA.
DR   RefSeq; XP_641182.1; XM_636090.1.
DR   AlphaFoldDB; Q54VC7; -.
DR   SMR; Q54VC7; -.
DR   STRING; 44689.DDB0237591; -.
DR   PaxDb; Q54VC7; -.
DR   EnsemblProtists; EAL67203; EAL67203; DDB_G0280449.
DR   GeneID; 8622563; -.
DR   KEGG; ddi:DDB_G0280449; -.
DR   dictyBase; DDB_G0280449; pitE.
DR   eggNOG; KOG3668; Eukaryota.
DR   HOGENOM; CLU_046509_3_0_1; -.
DR   InParanoid; Q54VC7; -.
DR   OMA; VENRPCE; -.
DR   PhylomeDB; Q54VC7; -.
DR   PRO; PR:Q54VC7; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
DR   GO; GO:0008525; F:phosphatidylcholine transporter activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0008526; F:phosphatidylinositol transfer activity; IBA:GO_Central.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR001666; PI_transfer.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   PANTHER; PTHR10658; PTHR10658; 1.
DR   Pfam; PF02121; IP_trans; 1.
DR   PRINTS; PR00391; PITRANSFER.
PE   3: Inferred from homology;
KW   Lipid transport; Lipid-binding; Reference proteome; Transport.
FT   CHAIN           1..287
FT                   /note="Phosphatidylinositol transfer protein 5"
FT                   /id="PRO_0000328408"
FT   REGION          252..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   287 AA;  33408 MW;  4D8843A7B157DC75 CRC64;
     MVLIKEFRIP LPLTVEEYKV AQLFMVATIS KKNTSLGEGI EVIENKPYAD GATTGFFTRK
     IFHLGGRLPT WLRSFAPTSL QIEEKAWNAY PYCKTSYACP LLGDRFSVSI ETRYEPDSGT
     QDNCLNLNSE ELSIREVEHI DIVNDPIDEA HYKPEEDPKI FQSVKTGRGK LQNDWMKSTK
     PIMCCYKVCK VEFRCWGVQN KVENFIQRVA LRDTFFMGHR QIFCWIDQWF DMDMESLREF
     EKKTNEEMKA QFHNNNNNNS NNSNNNNNNN TQPQRSSFFS RSTDGNK