ID   PITH1_DANRE             Reviewed;         210 AA.
AC   Q6NYX8;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=PITH domain-containing protein 1;
GN   Name=pithd1; ORFNames=zgc:77241;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in promoting megakaryocyte differentiation by
CC       up-regulating RUNX1 expression. {ECO:0000250|UniProtKB:Q9GZP4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9GZP4}.
CC   -!- SIMILARITY: Belongs to the PITHD1 family. {ECO:0000305}.
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DR   EMBL; BC066423; AAH66423.1; -; mRNA.
DR   RefSeq; NP_996957.1; NM_207074.1.
DR   AlphaFoldDB; Q6NYX8; -.
DR   SMR; Q6NYX8; -.
DR   GeneID; 404606; -.
DR   KEGG; dre:404606; -.
DR   CTD; 57095; -.
DR   ZFIN; ZDB-GENE-040426-2366; pithd1.
DR   InParanoid; Q6NYX8; -.
DR   OrthoDB; 1561790at2759; -.
DR   PhylomeDB; Q6NYX8; -.
DR   PRO; PR:Q6NYX8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   Gene3D; 2.60.120.470; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR045099; PITH1-like.
DR   InterPro; IPR010400; PITH_dom.
DR   InterPro; IPR037047; PITH_dom_sf.
DR   PANTHER; PTHR12175; PTHR12175; 1.
DR   Pfam; PF06201; PITH; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   PROSITE; PS51532; PITH; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..210
FT                   /note="PITH domain-containing protein 1"
FT                   /id="PRO_0000285034"
FT   DOMAIN          19..191
FT                   /note="PITH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00864"
SQ   SEQUENCE   210 AA;  24058 MW;  8E311350371FE2F0 CRC64;
     MSGHGHGHGH GHGCCECEHE PAERGVEYEL YRRIDIEKLQ CLNESRDGDG KLVFKPWDQR
     TDRNKFVESD ADEELLFNIP FTGSVKLKGI IISGEDDESH PAEIRLFKNI PQMSFDDTSR
     EPEQAFRLNR DPRAELEYPT KIARFSNVEH LSIHVSRNFG AESTRVYYIG LRGEYTEAHR
     HEVTICNYEA AANPADHKVE SITPQTQFIS